Efficacy of exapar in induction of uterine contraction in vitro and expulsion offetal membranes in buffaloes

Abstract

Efficacy of exapar (a polyherbal product) was evaluated in inducing uterine muscle contraction in vitro and in prevention
and treatment of retention of fetal membranes (RFM) in buffa loes. In experiment I, pieces of estrus goat uterine tissues obtained
from slaughter house were exposed to exapar liquid in isolated tissue bath with continuous aeration. A tension of I gm weight was put
to the tissue and the response of the ti ssues to exapar was recorded using a student Kymograph. In experiment 2, exapar liquid was
orally admi nistered to bu ffaloes just after calving to observe the effect of exapar on the time of expulsion of fetal membranes and
reproductive performance. In experiment 3, exapar liquid was administered orally to buffaloes for the treatment of retained fetal
membranes. In experiment I, exapar was found to induce a dose-dependent contractile response on isolated estrous goat uterus.
Experiment 2 showed significantly earlier expulsion of fetal membranes (4.88±0.51 Vs 7.33±0.74 hr, P < 0.05) and earlier
involution of uterus (43 .29±2.41 Vs 49.00±2.20) but no effect on the time required for appearance of first post-partum estrus in
exapar treated group than in control group. In experiment 3, no significant differences were observed in the time required for
expulsion of fetal membranes and onset of first post partum estrus in exapar treated group than in control group.