Histopathological studies in canine transmissible venereal tumour

Authors

  • ANITA JAIN Department of Obstetrics and Gynaecology, College of Veterinary Science and Animal Husbandry, P.B. No. 6, Anjora, DURG (C.G.) 491001
  • R P TIWARl
  • S K TIWARI
  • NEELU GUPTA
  • M K AWASTHl

Keywords:

Canine venereal tumour, histopathology, vincristine sulphate

Abstract

Six dogs, naturally affected with Transmissible venereal Tumour (TVT) were treated with vincristine
sulfate @ 0.025 mg/kg body weight intravenously (IN) at weekly interval for 5 weeks. The TVT affected tissues
were collected with Neilson biopsy punch on day O (before treatment) and on day 3 and 7, occasionally on day 14
after treatment, Appreciable degenerative changes were observed in nuclei and cytoplasm of tumour cells after
3rd day of treatment while after 7th day marked lymphocytic infiltration and increased amount of fibrous tissues
were seen along with appreciable reduction in tumour cells. The primary effect ofvincristine sulfate was on nuclei
of TVT cells causing their condensation, karyorhexis and karyolysis. Present study confirmed that vincristine
sulfate completely regressed the TVT in dogs.

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Published

2023-02-04

Issue

Vol. 23 No. 1 (2002): Indian Journal of Animal Reproduction

Section

Research Article

How to Cite

JAIN, A., TIWARl, R.P., TIWARI, S.K., GUPTA, N., & AWASTHl, M.K. (2023). Histopathological studies in canine transmissible venereal tumour. The Indian Journal of Animal Reproduction, 23(1), 60–62. Retrieved from https://acspublisher.com/journals/index.php/ijar/article/view/5634