EFFICACY OF IMMUNOMODULATORS FOR TREATMENT OF ENDOMETRITIS IN COWS

Abstract

The relative efficacy of intrauterine (IU) immunomodulators, viz., E. coll lipopolysaccharide (LPS), Oyster
Glycogen (OG) and Autologus Plasma (AP) in the treatment of endometritis in cows was investigated. Forty
endometritic cows were randomly divided into 4 groups (n=10) and were marked as T1 T2, T3 and T 4. The T 4 group
was kept as control with single dose Phosphate Buffer Solution(PBS) infusion. White side test, pH and bacterial
load were estimated before and after treatment in uterine discharge for diagnosis and clinical evaluation, respectively
while at estrus. At post treatment subsequent estrus A.I. was done in the recovered cows. Recovery and conception
percentage out of total animals treated were 100.00, 80.00, 60.00, 20.00% and 90.00, 80.00, 50.00 and 20.00 in
group T1 T2, T3 and T4, respectively. The results indicated the efficacy and possibility of using E.coli LPS, OG
and AP as alternative therapy of endometritis in crossbred cows.