EFFECT OF INTRAUTERINE IMMUNOTHERAPY ON UTERINE CELLULAR DYNAMICS AND CONCEPTION RATE IN ENDOMETRITIC COWS

Abstract

The efficacy of three intrauterine (IU) immunomodulators was investigated in endometritis of cross bred
cows. ·Forty endometritic cows were divided into 4 groups (n=10) and marked as T1
, T2
, T3 and T4 T1 cows received
E. coli lipopolysaccharide (LPS). Oyster Glycogen (OG) and Autologus Plasma (AP) were used in group T2 and T3,
respectively. T4 was kept as control with single infusion of 60ml Phosphate Buffer Solution (PBS, pH-7.2). After
24 hours of treatments significant (P<0.01) increase of neutrophils and lymphocytes in uterine flushing were
observed with significant (P<0.01) reduction in epithelial denudation in all treatment groups. Conception rate
increased significantly (P<0.01) in groups T1
, T2
, and T3
. The results indicated that intrauterine immunomodulators
can be used as alternative to antibiotic in resolving endometritis in cows.