TREATMENT OF PYOMETRA IN FEMALE DOGS USING PROSTAGLANDIN F2α ± ANTIPROGESTIN (MIFEPRISTONE)

Authors

  • M A SHAH Division of Veterinary Gynaecology and Obstetrics Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Jammu - 181 102
  • N PANDE
  • I A SHAH
  • R AGRAWAL
  • U SHARMA
  • S P S GHUMAN

Keywords:

Canine, Dog, Mifepristone, PGF2α,, Pyometra

Abstract

The female dogs confirmed for pyometra by history, clinical examination, ultrasonography and blood sampling
were subjected to prostaglandin F2α (PGF2α) therapy with or without mifepristone, an antiprogestin (n=6 in each
group). Following treatment, 11 out of 12 animals were successfully treated and recurrence till next estrous cycle was
observed only in one case. The clinical signs uterine diameter and hemato-biochemical parameters were normalized
by day 14 post onset of treatment in both the groups (p<0.05). By day 7, plasma progesterone decreased (p<0.05) in
group receiving PGF2α alone, but increased in group receiving antiprogestin plus PGF2α. Briefly, mifepristone appears
to be a safe and promising option for opening the cervical canal in closed pyometra cases of dogs and if used in
combination with PGF2α, a success rate of upto 100% for the treatment of either type of pyometra can be expected in
the absence of ovarian cysts.

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Published

2016-05-11

Issue

Vol. 37 No. 1 (2016): Indian Journal of Animal Reproduction

Section

Research Article

How to Cite

SHAH, M.A., PANDE, N., SHAH, I.A., AGRAWAL, R., SHARMA, U., & GHUMAN, S.P.S. (2016). TREATMENT OF PYOMETRA IN FEMALE DOGS USING PROSTAGLANDIN F2α ± ANTIPROGESTIN (MIFEPRISTONE). The Indian Journal of Animal Reproduction, 37(1), 23–26. Retrieved from https://acspublisher.com/journals/index.php/ijar/article/view/3499