ISCHEMIC HEART DISEASE: PATHOLOGY AND AUTOPSY DIAGNOSIS
Keywords:
Patients, Ischemic Heart DiseaseAbstract
Ischemic Heart Disease [IHD] is a generic designation for a group of related syndromes resulting from myocardial ischemia-an imbalance between cardiac blood supply (perfusion) and myocardial oxygen demand1. Myocardial infarction is defined by pathology as myocardial cell death due to prolonged ischaemia, which is the result of a perfusion imbalance between supply and demand. Cell death is categorized pathologically as coagulation and/or contraction band necrosis, which usually evolves through oncosis, but can result to a lesser degree from apoptosis.
References
1. Kumar V, Abbas A, Fausto N. Robins Basic Pathology 7th edition. Philadelphia: Elsevier Inc; 2004; 571-87. 2. Knight B, Saukko P. Knights forensic pathology, 3rd edition. London: Edward Arnold Publishers Ltd; 2004; 492-502.
3. Davies M, Woolf N, Robertson W. Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi. British Heart Journal, 1976, 38; 659-664.
4. Bashe WJ, Baba N, Keller DM, Geer JC, Anthony JR. Pathology of atherosclerotic heart disease in sudden death. Supplement III to Circulation. 1975 Dec; 51-52(3):63-69.
5. Farb A, Tang AL, Burke A, Laura S et al. Frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction. Circulation. 1995 Oct; 92(7): 1701-09.
6. Jie Ouyang et al. Utility of desmin and a Masson’s trichrome method to detect early acute myocardial infarction in autopsy tissues. Int J Clin Exp Pathol 2010; 3(1):98-105.
7. Ricardo H.B. et al. In Situ Apoptosis Assay for the Detection of Early Acute Myocardial Infarction. American Journal of Pathology; 1996; 149(3):821-829.
8. Rubin R, Strayer D, Rubin E, Shwarting R, Gorstein F. Rubin’s pathology, 4th edition. Maryland, USA: Williams and Wilkins; 2005; 541-58.
9. Baroldi G, Radice F, Schmid G, Leone A. Morphology of acute myocardial infarction in relation to coronary thrombosis. American Heart Journal. 1974 Jan; 879(1):65-75.
10. Reichenbach DD, Moss NS, Meyer E. Pathology of heart in sudden cardiac death, The American Journal of Cardiology. 1977 May 26; 39:865-72.
11. Rodriguez-calvo MS, Tourret MN, Concheiro L, Munoz J, Suarez-Penaranda J. Detection of apoptosis in Ischemic heart, usefulness in Diagnosis of early myocardial injury. American journal of Forensic Medicine and Pathology. 2001; 22(3): 278-84.
12. Toshinobu H, Morie S, Koshichiro H. Coronary thrombosis in pathogenesis of acute myocardial infarction Histopathological study of coronary arteries in 108 necropsied cases using serial section; British Heart Journal, 1978, 40, 153-161.
13. Bernard B, Guido M. Histopathology of Early Myocardial Infarcts: A New Approach. American Journal of Pathology; 1974 Feb, 74(2); 301-318.
14. Michael J. Pathological view of sudden Cardiac death. Br Heart J 1981; 45: 88-96.
15. Takeshi T et al. Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Cardiovascular Research.2003; 59: 926–933.