BROMADIOLONE POISONING - A FATAL CASE OF SUICIDAL INGESTION

Authors

  • Hareesh S Gouda Associate Professor, Dept. of Forensic Medicine & ToxicologyFather Muller Medical College, Mangalore, Karnataka, India
  • Nagesh KR Professor & Head, Dept. of Forensic Medicine & Toxicology Father Muller Medical College, Mangalore, Karnataka, India

Keywords:

Suicide, Clinical toxicology, Rodenticide, Anticoagulant, Bromadiolone, Vitamin K, Acute tubular necrosis

Abstract

Bromadiolone is an active ingredient of many newer rodenticides available in the market, for the reason that it is highly fatal for rodent species. Because of its easy availability, it is becoming the poison of choice for committing suicide. Bromadiolone inhibits vitamin K (1)- 2,3 epoxide reductase and thus the synthesis of vitamin K and subsequently clotting factors II, VII, IX and X. Herein, we present a case of fatal suicidal ingestion of bromadiolone rodenticide bait by a young adult woman.

References

Hadler MR, Buckle AP. Forty five years of anticoagulant rodenticides - Past, present and future trends. Proceedings of the Fifteenth Vertebrate Pest Conference.1992. pp. 149-55. Available from: http:// digitalcommons.unl.edu/vpc15/36 (last checked 10 March 2012).

Meehan AP. Rodenticidal activity of Bromadiolone - A new anticoagulant. Proceedings of the 8th Vertebrate Pest Conference.1978. pp. 122-6. Available from: http://digitalcommons.unl.edu/vpc8/31 (last checked 10 March 2012).

Watt BE, Proudfoot AT, Bradberry SM, Vale JA. Anticoagulant rodenticides. Toxicol Rev. 2005; 24(4): 259-69.

Poche RM. The status of Bromadiolone in the United States. Proceedings of the Twelfth Vertebrate Pest Conference.1986. Paper 50. pp. 6-15. Available from: http://digitalcommons.unl.edu/vpc12/50 (last checked 10 March 2012).

Chow EY, Haley LP, Vickars LM, Murphy MJ. A case of bromadiolone (superwarfarin) ingestion. Can Med Assoc J. 1992; 147 (1): 60-2.

Manjunatha B, Verghese AJ, Mestri SC, Pramodkumar GN. A Case of Suicidal Rat Poisoning Masquerading as Homicide. J Indian Soc of Toxicol. 2011; 7(1): 41-3.

World Health Organization report on the International Programme on Chemical Safety. Health and safety guide for Bromadiolone (Health and safety guide; no. 94). Available from: http://www.inchem.org/ documents/hsg/hsg/hsg094.htm (last checked 12 March 2012).

Published

2013-01-30

How to Cite

BROMADIOLONE POISONING - A FATAL CASE OF SUICIDAL INGESTION . (2013). Journal of Forensic Medicine & Toxicology, 29(2), 44–46. Retrieved from https://acspublisher.com/journals/index.php/jfmt/article/view/17585