CONCEPTUAL STUDY ON THE MANAGEMENT OF FRESH WOUND: A REVIEW ARTICLE
Keywords:
Wound healing, Herbal formulations, Infection, Antimicrobial activityAbstract
Wound healing is a normal biological process that occurs natu rally as long as the infection does not hinder it. Both freshly prepared incisional and excisional wound experimental models, several monoherbal and polyherbal formulations have been reported to hasten / accelerate wound healing process.Different herbal formulations have been reported to hasten/accelerate the process of wound healing by enhancing epitheliazation, neovascularization, formation of granulation tissue, collagen synthesis, wound contraction, tensile strength, etc. As these studies have been conducted in freshly prepared non-infected wounds, it is difficult to ascertain the wound healing potential of these formulations in absence of microbial colonization/infection and results are not justifiable because the healing is limited to non-infected wounds. In experimental animals in the presence of colonization / infection, it would be more appropriate to determine the wound healing potential and not to hasten / accelerate the wound healing property of newer herbalformulations on wound healing. Hence, it is recommended to strengthen these study protocols further using suitable controls to find out the antimicrobial activities of herbal formulations and their effect on wounds colonized/infected with pathogenic microbes in significant numbers to achieve more meaningful and concrete conclusions.
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References
M.C. Robson Disturbances in wound healingAnn Emerg Med, 17 (1988), pp. 1274-1278 [2] R.W. Tarnuzzer, G.S. Schultz Biochemical analysis of acute and chronic wound environmentswound Repair Regen, 4 (1996), p. 321
M.C. RobsonWound infection. A failure of wound healing caused by an imbalance of bacteriaSurg Clin N Am, 77 (1997), pp. 637-650
G.S. Lazarus, D.M. Cooper, D.R. Knigtton, D.J. Margolis, R.E. Pecoraro, G. Rodeheaver, et al.Definitions and guidelines for assessment of wounds and evaluation of healingArchDermatol, 130 (1994), pp. 489-493
J.F. BurkeThe effective period of preventive antibiotic action in experimental incisions and dermal lesions Surgery, 50 (1961), pp. 161-168
M.S. Kumar, R. Sripriya, H.V. Raghavan, P.K. SehgalWound healing potential of Cassia fistula on infected albino rat modelJ Surg Res, 131 (2006), pp. 283-289 [7] Gujarat Ayurveda University, I.P.G.T. & R.A., Jamnagar
Vrana Ek Adhayayana by Dr. Pandya, K.K. in 1974.
Vrana Sodhana and role of Karanja by Dr. Trivedi, H.S. in 1979.
A study of the effect of certain indigenous by Dr. Sharma, M.D. in 1979. 4) A comparative study of 60 measures of Vrana and the role of Madhu Sarpi in Vrana Ropana by Dr. Chandra Amrut Kumar in 1981
Role of certain Indegenous drugs in the management of Vrana Ropana by Dr. ThomasmT. In 1986.
Role of Karanjadi Ghrita in Dushta Vrana with special reference to chronic infected wound by Dr. Chovatiya N.M.
Role of Sodhana and Ropana Ayurvedic drug in special reference to Dushta Vrana by Dr. Chowdhary A.R. in 1990.
Clinical and Experimental Studies of Yastimadhvadi Compound in Vrana Ropana by Dr. Gupta, R. in 1995.
]I.M.S., Banaras Hindu University; Varanasi.
Wound healing and tissue regeneration under influence of the drug “Mansa Rohini” by Dr. I. Sanjeeva Rao in 1966.Historical Review-[Evaluation of the Efficacy of Arkadi Gana Ointment and Lotion in Vrana (An Experimental Study) Page 9]
Healing of wound in Diabetes under the influence of “Udumbara” by Dr.Agrawal, J.S. in 1967
Corneal wound healing under the influence of indigenous drugs by Dr.Sharma, C.P. in 1967.
Studies on Vrana Ropana by Dr. Mishra, S.N. in 1969.
Studies on Vrana Sodhana by Dr. Sharma, S.K. in 1971.
Ayurvedic Collage, Bangalore.
Effect of Ksara Taila in Dushta Vrana by Dr. Shetty, Narayana in 1987. 2) Study of action of “Bandhana Karana” through “Patradana”in VranaChikitsa by Dr. Huvin, S.V. in 1988.
Effect of “Kasisadi Taila” in Dustavrana by Dr. Mashetti, N.B. in 1989. 4) Effect of “Triphala Guggulu” in the management of Vrana by Dr. Sinha, R.K. in 1989. 5) An experimental study of the effect of “Ksudra Seventika” in “Sadhyo Vrana” by Dr. Narsimha in 1990.
Government Ayurvedic Collage, Thiruvanthapuram.
Effect of “Murivenna” in healing of Dushta Vrana by Dr. Anitha, O. in 1989. 2) Clinical study in DushtaVrana with“RasKarpooradi Dhupanam”& Rasa Sinduram by Dr.Sanjeev,L.B. in 1990.
Management of Dusta Vrana with Karkaradi Ghritam by Dr. Bindu, B. in 1993. [11] Ayurvedic Collage, Nagpur
Role of “Udumbara Kshara” in treatment of DushtaVrana by Dr.Qureshi,F.in 1993. [12]Ayurvedic Collage, Hyderabad.
Study of Vajraka Tailam in Dushta Vrana by Dr. Sarangpani, S. in 1985.Management of Dagdha Vrana with “Swatha Malhar” by Dr. Prasad,2. K.M. in 1987.
Svarna Kshiri in the management of Dushta Vrana by Dr. Najraj, N. in 1990. 3) Management of Dusta Vrana with “Karanjadi Tailam” by Dr. Rao, P. in 1991. [13]N.I.A., Jaipur.
A comparative of Shodhana effect of Jalaukavacharana and Tilanimbapatra kalka lepa in Dushta Vrana By Dr. Deepa, in 2014.[Historical Review -Evaluation of the Efficacy of Arkadi Gana Ointment and Lotion in Vrana (An Experimental Study) Page 10]
A Clinical study on role of Sushrutokta Madhumishrit Tilkalka in non-healing ulcer, By Dr.(Mrs.) Deepali Sundari Verma, in 2013.
Effect of Patolyadi Kwath & Kampillakadi Tail in the Management of SadyoVrana with special reference to Traumatic Wound, By Dr. Shikha, in 2013.
Phytochemical Analysis and Antimicrobial Study of Formulation prepared by Arkadi Gana. By Dr. Premsukh ,in 2015.
Shodhana effect of Karviradi Rasakriya in the Dushta Vrana along with Antimicrobial Study, By Dr. Shikha, in 2016
Evaluation of the efficacy of Arkadi Gana Ointment and Lotion in Vrana (An Experimental Study)”The trial drug has shown better results when used in ointment form has been carried out by Dr.Rakesh Prasad 2018
An Experimental Study to Assess the Anti-inflammatory and Analgesic Properties of Nirgundi Extract”in partial fulfilment of the requirements ] by Dr.Rakesh Kumar Rathore, NIA, Jaipur 2017
Conceptual Study on Vrana w.s.r. to Vranaupakrama and their Application in Present Context by Dr. Dinesh Kumar Aherwara NIA, Jaipur 2019
An Experimental Study To Validate The Efficacy Of “Samangadi Taila” On Wound Healing in a Rat Model is under research process.Dr.Manmahendra singh in NIA,Jaipur [18] M. Davane, B. NagobaWound healing effects of Bambusa vulgaris leaves J Ayurveda Integr Med, 7 (2016), p. 185
B.S. Nagoba, B. WadherEfficacy of Jasminum grandiflorum L. leaf extract on dermal wound healing in rats in the presence of infection Int Wound J, 13 (2016), p. 1031
