Preclinical Evidence on the Cardio Protective Activity of Prisniparni  (Desmodium Gangeticum (L.) Dc) in Myocardial Ischemia Reperfusion  Injury: A Narrative Review.

Mridula MK; PA Ansary; Sara Moncy Oommen; V V Shincymol; Sethu R

doi:10.48165/

Authors

Mridula MK Assistant Professor Dept.Of Dravyaguna vijnana Govt.Ayurveda College Tripunithura Author
PA Ansary Professor & HOD Dept. Of Dravyaguna vijnana, Govt. Ayurveda College Tripunithura Author
Sara Moncy Oommen Professor & HOD, Dept. Of Dravyaguna vijnana Govt. Ayurveda College Kannur Author
V V Shincymol Associate Professor Dept. Of Dravyaguna vijnana Govt. Ayurveda College Tripunithura Author
Sethu R Assistant Professor Dept.Of Dravyaguna vijnana Govt. Ayurveda College Tripunithura Author

DOI:

https://doi.org/10.48165/

Keywords:

Desmodium gangeticum, Myocardial ischemia reperfusion, Herbal medicine, Cardioprotection, Ayurveda

Abstract

Heart failure developed by Myocardial Ischemia and Ischemia reperfusion injury has been a major challenge for medical science with its mortality and morbidity rate, worldwide. The need of the hour is medical interventions that can reduce injury from myocardial ischemia and reperfusion. It’s here where herbal medicines can play a pivotal role, as it is used in invention of many commercial drugs. Prisniparni (Desmodium gangeticum (L.) DC is a widely used medicinal plant in Ayurveda for various ailments especially in cardiac diseases. Medicated milk prepared from Prisniparni is advised in Vatika hridroga chikitsa. This review highlights the cardio protective activity of Desmodium gangeticum (L.) DC) seen in several preclinical models of Myocardial Ischemia reperfusion injury. A thorough literature search lead to 6 studies that met the inclusion criteria .Results of these studies pointed out the free radical scavenging activity of the plant Desmodium gangeticum (L.) DC during Ischemia and Ischemia reperfusion. Which majorly helped in cardio protection by preserving mitochondrial respiratory enzymes.

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References

Thygesen et al. Universal definition of myocardial infarction. Circulation. 27 November 2007; volume116 issue 22: pages 2634-2653.

Derek J. Myocardial ischemia-reperfusion injury: a neglected therapeutictarget.J Clin Invest. 2013;123(1):92- 100.

Yellon DM. Myocardial reperfusion injury. N Engl J

Med. 2007; 357:1121-1135

Derek J.Myocardial ischemia-reperfusion injury: a neglected therapeutictarget.J Clin Invest. 2013;123(1):92- 100.

Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective.NatRev Cardiol. 2020 Dec;17(12):773-789. doi: 10.1038/s41569-020-0403-y. Epub 2020 Jul 3. PMID: 32620851.

Schluter KD, Protection of reoxygenatedcardiomyocytes against osmotic fragility by nitric oxide donors. Am J Physiol. 1996 Aug;271(2 Pt 2):H428-34. doi: 10.1152/ajpheart.1996.271.2.H428. PMID: 8770080.

Simon R.J Lip. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options.Int. J. Cardiol. 1997;Volume 58, Issue 2:Pages 95- 117.ISSN 0167-5273,https://doi.org/10.1016/S0167-

(96)02854-9.

Petrosillo G, Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin. FASEB J. 2003 Apr;17(6):714-6. doi: 10.1096/fj.02-0729fje. Epub 2003 Feb 5. PMID: 12586737.

Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol. 2020 Dec;17(12):773-789. doi: 10.1038/s41569-020-0403-y. Epub 2020 Jul 3. PMID: 32620851.

Mashour NH, Herbal Medicine for the Treatment of Cardiovascular Disease: Clinical Considerations. Arch Intern Med. 1998;158(20):2225–2234. doi:10.1001/archinte.158.20.2225

.Liming Yu, Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information RegulatorOxidativeMed.Cell.Longev.vol.2016;16pages:A

rticleID1689602 https://doi.org/10.1155/2016/1689602. 12. Mokhtari‐Zaer A, The protective role of curcumin in myocardial ischemia–reperfusion injury.J Cell Physiol. 2018 Jan; 234(1):214-222. doi: 10.1002/jcp.26848. Epub 2018 Jul 3. PMID: 29968913.

Kurian, G.A., Antioxidant effects of ethyl acetate extract of Desmodiumgangeticum root on myocardial ischemia reperfusion injury in rat hearts. Chin Med 5, 3 (2010). https://doi.org/10.1186/1749-8546-5-3

Kurian, G.A., Methanol extract of Desmodiumgangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by reperfusion injury.J. Pharm. Pharmacol. 2008 April;60(4):523-30.

Kurian, G.A., Jose Paddikkala. Administration of aqueous extract of Desmodiumgangeticum (L) root protects rat heart against ischemic reperfusion injury induced oxidative stress. Indian J of Exp Biol. 2009 Feb;47(2):129-35. PMID: 19374168.

Iyer K. Pharmacognosy of Ayurvedic drugs. Revised edition 1978. Published by Govt of Kerala; Series 1, Number2: Page no.75.

SivarajanV.V , Indira Balachandran. Reprint Edition 1994. New delhi: Oxford&Publishing co-Pvt Ltd; p382- 383.

Singh A, Bhavamisra.Bhavaprakasha Nighantu chapter 3,Guduchyadi varga sloka no 33-34 2007. Varanasi: Chaukhambha Orientalia.2007.pp.80

Sasri H, Vagbhata. Astangahridaya Reprint Edition Uttarasthana Chapter 1,sloka 20 Varanasi: Chaukhambha Sanskrit Sansthan; 2010.pp.778.

Trikam J, Susrutha. Susrutha samhitha Edited by Reprint Edition Sarira sthana chapter10 ,sloka 61Varanasi: Chaukhambha Sanskrit Sansthan;2010.pp. 394. 21. Sasri H, Vagbhata. Astangahridaya Reprint Edition Uttarasthana Chapter 1,sloka 20 Varanasi: Chaukhambha Sanskrit Sansthan; 2010.pp.861.

Sharma R.K, Agnivesa. Carakasamhita.Reprint, Chapter 28, sloka 96Varanasi: Chaukhambha Sanskrit series office; Volume V.2016.pp.49.

Namboothiri S. Chikitsamanjari. 8thedition, Hridrogachikitsa Alappuzha: Vidyarambham Publishers; 2008.pp.159.

Kurian GA, Effect of aqueous extract of the Desmodiumgangeticum DC root in the severity of myocardial infarction. J Ethnopharmacol. 2005 Mar 21;97(3):457-61. doi: 10.1016/j.jep.2004.11.028. PMID: 15740881.

Kurian, G.A., Suryanarayanan, S., Raman, A. et al. Antioxidant effects of ethyl acetate extract of Desmodiumgangeticum root on myocardial ischemia reperfusion injury in rat hearts. Chin Med 5, 3 (2010). https://doi.org/10.1186/1749-8546-5-3

Kurian,G.A, Paddikkala,J. Methanol extract of Desmodiumgangeticum DC root mimetic post conditioning effect in isolated perfused rat heart by stimulating muscarinic receptors.Asian Pac. J. Trop. Med. 2012 Jun;5(6):448-54.doi: 10.1016/S1995- 7645(12)60076-5.

Kurian, G.A.,Yagnesh, N., SanchitKishan, R. Jose Paddikkala. Methanol extract of Desmodiumgangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by

reperfusion injury.J. Pharm. Pharmacol. 2008 April;60(4):523-30. doi: 10.1211/jpp.60.4.0016,PMID: 18380926 DOI: 10.1211/jpp.60.4.0016.

Srivats S, Ramakrishnan G, Paddikkala J, Kurian GA. An in vivo and in vitro analysis of free radical scavenging potential possessed by Desmodiumgangeticum chloroform root extract: interpretation by gsms.Pak. J. Pharm. Sci.2012 Jan;25(1):27-34. PMID: 22186306.

Kurian, G.A.,Paddikkala,J. Administration of aqueous extract of Desmodiumgangeticum (L) root protects rat heart against ischemic reperfusion injury induced oxidative stress. Indian J of Exp Biol. 2009 Feb;47(2):129-35. PMID: 19374168.

Kurian, G.A., Paddikkala, J. (2010). Oral delivery of insulin with Desmodiumgangeticum root aqueous extract protects rat hearts against ischemia reperfusion injury in streptozotocin induced diabetic rats.Asian Pac. J. Trop. Med..(2010); 3. 94–100. 10.1016/S1995-7645(10)60043- 0.

Kurian GA, Selvam GS, Saranya V. Oral administration of insulin mixed desmodiumgangeticum root aqueous extract reduces oxidative stress mediated by myocardial ischemia reperfusion in isolated rat hearts. J Pharmacy R. 2009; 2(6): 1013-8.

Ibarrola, J., Matilla, L., Martínez-Martínez, E. et al. Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition. Sci Rep 9, 9607 (2019). https://doi.org/10.1038/s41598-019- 46119-6

Kurian, G.A.,Yagnesh, N., SanchitKishan, R. Jose Paddikkala. Methanol extract of Desmodiumgangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by reperfusion injury.J. Pharm. Pharmacol. 2008 April;60(4):523-30. doi: 10.1211/jpp.60.4.0016,PMID: 18380926 DOI: 10.1211/jpp.60.4.0016.

Heusch G. Myocardial ischaemia-reperfusion injury

and cardioprotection in perspective. Nat Rev Cardiol. 2020 Dec;17(12):773-789. doi: 10.1038/s41569-020-0403-y. Epub 2020 Jul 3. PMID: 32620851.

Liming Yu, Qing Li, Bo Yu et al. Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.OxidativeMed.Cell.Longev.vol.2016;16pages:ArticleID

https://doi.org/10.1155/2016/1689602. 36. Afsheen N, Khalil-Ur-Rehman, Jahan N, Ijaz M, Manzoor A, Khan KM, Hina S. Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress. Oxid Med Cell Longev. 2018 Jan 14;2018:9819360. doi: 10.1155/2018/9819360. PMID: 29576858; PMCID: PMC5821957.

Rastogi S, Pandey MM, Rawat AK. An ethnomedicinal, phytochemical and pharmacological profile of Desmodiumgangeticum (L.) DC. and Desmodiumadscendens (Sw.) DC. J Ethnopharmacol. 2011 Jun 22;136(2):283-96. doi: 10.1016/j.jep.2011.04.031. Epub 2011 Apr 20. PMID: 21530632.

Kurian, G.A.,Yagnesh, N., SanchitKishan, R. Jose Paddikkala. Methanol extract of Desmodiumgangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by reperfusion injury.J. Pharm. Pharmacol. 2008 April;60(4):523-30. doi: 10.1211/jpp.60.4.0016,PMID: 18380926 DOI: 10.1211/jpp.60.4.0016.