Safety Evaluation of repeated oral administration of Gemifloxacin in Broiler Birds

Authors

  • R.H. Gohel Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India
  • K.A. Sadariya Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India
  • J. J. Maradiya Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India
  • A.M. Thaker Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India

Keywords:

Gemifloxacin, Broiler birds, Haematology, Serum Biochemistry

Abstract

Gemifloxacin is a fourth generation fluoroquinolone drug having broad-spectrum and good antibacterial activity at low plasma/tissue concentration. The present study was designed to investigate safety of gemifloxacin @ 10 mg/kg body weight after repeated oral administration at 24 hr interval for 5 days in 6 broiler birds of 5-6 week age. It was found safe based on non-significant alteration in haematological (Hb, PCV, TEC and TLC) and serum biochemical (AST, ALT, ACP, ALP, LDH, creatinine, total bilirubin and uric acid) parameters that were evaluated before and at 24 hourly interval for 5 days during treatment. 

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Published

2018-04-08

Issue

Vol. 13 No. 4 (2018): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Apr- Jun) 2018

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Gohel, R., Sadariya, K., Maradiya, J.J., & Thaker , A. (2018). Safety Evaluation of repeated oral administration of Gemifloxacin in Broiler Birds. Indian Journal of Veterinary Sciences and Biotechnology, 13(4), 1–4. Retrieved from https://acspublisher.com/journals/index.php/ijvsbt/article/view/2671