Successful Adjunctive Vincristine–Ivermectin Therapy for Pars Bulbus Glandis CTVT in Two Intact Male Dogs

Authors

  • Kangonu Anthony Raju Department of Veterinary Gynaecology and Obstetrics,
  • Francis Sebastin Raju Department of Veterinary Clinical Complex, School of Veterinary and Animal Sciences, CUTM, Paralakhemundi, 761211 Odisha
  • Allada Uday Kiran Department of Veterinary Gynaecology and Obstetrics,
  • Nuka Likitha Department of Veterinary Clinical Complex, School of Veterinary and Animal Sciences, CUTM, Paralakhemundi, 761211 Odisha.
  • Saranya Paidi Department of Veterinary Clinical Complex, School of Veterinary and Animal Sciences, CUTM, Paralakhemundi, 761211 Odisha

DOI:

https://doi.org/10.48165/ijar.2026.47.01.18

Keywords:

Canine Transmissible Venereal Tumour, Ivermectin, Non-Descript, Vincristine sulfate

Abstract

Two non-descript male dogs, aged two and four years, were presented with a history of bloody discharge, paraphimosis and pedunculated masses at pars bulbus glandis of penile shaft. Based on physical and cytological examinations, the con dition was diagnosed as Canine Transmissible Venereal Tumour (CTVT). The successful tumour remission was achieved using a weekly adjuvant chemotherapy protocol involving intravenous vincristine sulfate (0.5- 0.7 mg/m2 of body surface area) and subcutaneous ivermectin (0.2mg/kg b wt).

Author Biographies

  • Kangonu Anthony Raju, Department of Veterinary Gynaecology and Obstetrics,

    School of Veterinary and Animal Sciences, CUTM, Paralakhemundi, 761211 Odisha.

  • Allada Uday Kiran, Department of Veterinary Gynaecology and Obstetrics,

    School of Veterinary and Animal Sciences, CUTM, Paralakhemundi, 761211 Odisha.

References

Abeka, Y. T. (2019). Review on canine transmissible venereal tumor (CTVT). Cancer Therapy & Oncology International Journal, 14(4), R86-R94.

Avazi, D.O., Alo-Aleje, H.O., Tanko, P.N., & Galadima, M. (2024). Surgical Management of Canine Transmissible Venereal Tumor with Adjunctive Chemotherapy Combination. Research in Veterinary Science and Medicine.,4(4), R1-R5.

Biswas, N., Singh, K., Kumar, S., Parmar, S., Srivastava, N., & Khan, M. H. (2024). Therapeutics and Management of Persistent Cases of Canine Transmissible Venereal Tumour: An Update. Animal Reproduction Update, 4(2), R1-R8.

Bulhosa, L.F., Estrela-Lima, A., da Silva Solcà, M., Gonçalves, G.S.D., Larangeira, D.F., de Pinho, F.A., & Barrouin-Melo, S.M. (2020). Vincristine and ivermectin combination che motherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospec tive outcome evaluation. Animal Reproduction Science., 216 pp.106358.

Devi, S. T. (2023). Haemato-biochemical evaluation of che motherapy in canine transmissible venereal tumour. The Indian Journal of Animal Reproduction., 44(1), R23-R27.

Gaspar, L.F.J., Ferreira, I., Colodel, M.M., Brandao, C.V.S., & Rocha, N.S. (2010). Spontaneous canine transmissi ble venereal tumor: cell morphology and influence on P-glycoprotein expression. Turkish Journal of Veterinary and Animal Sciences., 34(5), R447-R454.

Jiang, L., Wang, P., Sun, Y.J., & Wu, Y.J. (2019). Ivermectin reverses the drug resistance in cancer cells through EGFR/ ERK/Akt/NF-κB pathway. Journal of Experimental and Clinical Cancer Research., 38(1), R265.

Meena, S., & Meena, S. (2024). Canine transmissible venereal tumour. International Journal of Veterinary Science and Animal Husbandry, 9(1), R391-R394.

Reddy, R. S. H., Srinivas, M., & Praveen, K. S. (2022). A novel therapeutic combination of vincristine and ivermec tin in the treatment of transmissible venereal tumour in bitches. Indian Journal of Veterinary and Animal Sciences Research., 51(3), R79-R84.

Yadav, A., Bugalia, N., & Pandey, A. (2022). Haemato biochemical and therapeutic evaluation of doxorubicin and vincristine in canine transmissible venereal tumour. The Indian Journal of Animal Reproduction, 39(2), 40-42.

Published

2026-04-16

How to Cite

Raju, K. A., Raju, F. S., Kiran, A. U., Likitha, N., & Paidi, S. (2026). Successful Adjunctive Vincristine–Ivermectin Therapy for Pars Bulbus Glandis CTVT in Two Intact Male Dogs . The Indian Journal of Animal Reproduction, 47(1), 97-99. https://doi.org/10.48165/ijar.2026.47.01.18