Histopathological Study Of Thyroid Lesions

Authors

  • Biren Parikh Assistant Professor, Department of Pathology, AMC MET Medical College, Ahmedabad-380008
  • Kena Patel 2nd year Resident, Department of Pathology, AMC MET Medical College, Ahmedabad-380008
  • Anuradha Chilani 1nd year Resident, Department of Pathology, AMC MET Medical College, Ahmedabad-380008
  • Swati Parikh Professor, Department of Pathology, Smt. NHL Municipal Medical College, Ahmedabad-380006

DOI:

https://doi.org/10.48165/ijabms.2022.243824

Keywords:

Histopathology, Thyroid lesions, Non-neoplastic, Neoplastic

Abstract

Background:Thyroid lesions are fairly common worldwide and are commonly encountered in clinical practice. The incidence of various thyroid disorders shows a striking variation; both, on a national and regional basis. Thyroid gland can be affected by a wide spectrum of diseases ranging from functional and immunologically mediated enlargement to neoplastic lesions. Objective:This study was carried out to estimate the frequency of thyroid lesions with respect to histopathological types and to correlate thyroid lesions with demographic data and clinical features.Materials and Methods: This study included all types of thyroid specimens received in the department of Pathology; AMC MET Medical College, Ahmedabad from June 2019 to December 2020. Results:Among the total 40 cases of thyroid lesions studied, the non-neoplastic lesions accounted for 26 cases (65%) and the neoplastic lesions constituted 14 cases (35%). The most common non-neoplastic lesion was multinodular /adenomatoid goiter (50%), followed by Hashimoto thyroiditis (7.5%), thyroglossal duct cyst (5%) and diffuse hyperplasia (2.5%). The most common benign neoplasm was Follicular adenoma (7.5%) and the most common malignant neoplasm was papillary carcinoma (17.5%). Two cases (5%) of Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) of low / unknown malignant potential were reported.Conclusion: Histopathological examination of thyroid lesions provides definite diagnosis; which is mandatory for further management of patient.

References

Kochupillai N. Clinical endocrinology in India. Curr Sci 2000;79:1061-7.

Wartosfsky L. Diseases of the thyroid. Fauci AS, Braunwald E, Hauser SL, Longo DL, Jameson JL, editors. Principles of Internal Medicine. 14th ed. New York: McGraw-Hill; 1998. p. 2012-35

De Lellis RA, Lloyd RV, Heitz PU, Eng C. World Health Organisation Classification of Tumors. Pathology and Genetics of Tumors of Endocrine Organs. IARC Press: Lyon 2004;49-133

Aahana Gupta1 et al Histopathological study of thyroid lesions and correlation with ultrasonography and thyroid profile in western zone of Rajasthan, India, International Journal of Research in Medical Sciences Gupta A et al. Int J Res Med Sci. 2016 Apr;4(4):1204-1208

Lloyd R. V., Osamura R. Y., Kloppel G.,Rosai J. (Eds): WHO Classification of Tumours of Endocrine Organs(4th edition). IARC: Lyon 2017.ISBN 97892-832-4493-6

Antony J; Celine T M, Chacko M. Spectrum of Thyroid Disorders A Retrospective Study May1:11(2) 55 at Medical College Hospital. Thyroid Res Pract. 2014

Islam R, Ekramuddaula AFM, Alam MS , Kabir MS, Hossain D, Alauddin M. Frequency & pattern of malignancy in solitary thyroid nodule. Bangladesh J of Otorhinolaryngology. 2009;15(1):1-5

Sayan Ghoshal, Krishnaraj Upadhyaya:Clinico-pathological evaluation of thyroid lesions by FNAC and histopathology in a tertiary care hospital in Mangalore: MedPulse International Journal of Pathology, Print ISSN: 2550-7605, Online ISSN: 2636-4697, Volume 13, Issue 3, March 2020 pp 170-174

Ramesh V L, Shwetha R. Study of Distribution of the Thyroid Lesions in a Hospital. International Journal of Science and Research 2014 Dec 3, Dec 3(21): 2441-43

Jagadale K, Srivastava H, Nimburgi R, Recent Trends in Distribution of Thyroid Lesions in a Tertiary Care Hospital in India. Ejleps 2016, 3(4): 234-239

Raphael Solomon, Yawale Iliyasu1, A. Z. Mohammed. Histopathological pattern of thyroid lesions in Kano, Nigeria: A 10-year retrospective review (20022011). Nigerian Journal of Basic and Clinical Sciences. 2015; 12(1): 55-60.

Gole S et al. Profile Of Thyroid Neoplasms With Special Focus On Interesting Cases: A Hospital Based 12 Year Longitudinal Study. The Internet Journal of Pathology. 2013; 14(1):1-13

Bharathidasan I, Goneppanavas M, Dhaka R S. Changing Trends in the Incidence of Thyroid Lesions in Coastal Regions in South India. Ind J Health. Sci Res 2015; 5(6):134-141

Padmavati M, Raj JA. Histopathological Spectrum of Non-neoplastic and Neoplastic Lesions of Thyroid:A 5- year Prospective Study in a Tertiary Care Hospital. J Med Sci 2017;3(3):63-68.

Prabha V, Bhuvaneswari MG. A Study of Histopathological Spectrum of Thyroid Lesions: An Observational Study.Int J Sci Stud 2019;7(1):1-4

Patil R S, Nimbel N V, Pratima S, Sreekanta, Remya. Histopathological Study of Thyroid Lesions. IntJPharma Bio Sci; 4(4): 1003-1020

Golder Samir, Satpathy Shanta Nibedita, Padhy Rajesh Kumar, Panigrahi Rajlaxmi, Ghata Swarupjit. A Clinicopathological Study of Solitary Thyroid Nodule. J Pharm Biomed Sci 2015; 05(03): 233-237

Sherine I. Salama, Layla S Abdullah, Mohamed H. Al-Qahtani, Jaudah A. Al-Maghrabi. Histopathological pattern of thyroid lesions in western region of Saudi Arabia. The New Egyptian Journal of Medicine, 2009; 40(6): 580-585

Dr Sreedevi A R1, Dr Sheela K M. Histopathological Spectrum of Non Neoplastic and Neoplastic Lesions of Thyroid- 2 Year Study in a Tertiary Care Teaching Hospital.

Pradeepkumar NS, Singh R, Joseph NM. Emerging trends in thyroid diseases in Tsunami hit coastal areas of Puducherry and Cuddalore, India.Journal of Evolution of Medical and Dental Sciences. 2012;1(5):857-63.

Ahmed Z, Chaudhary R, Umaru N. Study of prevalence of thyroid lesions in coastal region of Karnataka. Journal of Evolution of Medical and Dental Sciences. 2013;2(36):6995-7002

Rahman MA, Biswas MA, Siddika ST, Sikder AM, Talukder SI, Alamgir MH. Histomorphological Pattern of Thyroid Lesion. Dinajpur Medical College Journal. 2013;6(2): 134-40.

Rosai & Ackerman surgical pathology First South Asia edition part one thyroid gland pg 296. Carney JA, Hirokawa M, Lloyd RV, et al. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol.2008;32(12):1877-1889. McCluggage WG, Sloan JM. Hyalinizing trabecular carcinoma of thyroid gland.Histopathology. 1996;28(4):357-362.Molberg K, Albores-Saavedra J. Hyalinizing trabecular carcinoma of the thyroid gland.Hum Pathol. 1994;25(2):192-197

McCluggage WG, Sloan JM. Hyalinizing trabecular carcinoma of thyroid gland. Histopathology. 1996;28(4):357-362

Rosai & Ackerman surgical pathology First South Asia edition part one thyroid gland pg 304

Nikiforov YE, Seethala RR, Tallini G, et al. Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol. 2016;2:1023-1029.

Published

2022-02-02

How to Cite

Histopathological Study Of Thyroid Lesions. (2022). Indian Journal of Applied-Basic Medical Sciences, 24(38), 210–218. https://doi.org/10.48165/ijabms.2022.243824