Efficacy of Momordica charantia in alleviation of  streptozotocin- induced diabetes effects in rats

Mallikarjuna  G; Suguna  Rao; Shridhar N B; Sathyanarayana M L; Byregowda S M; Dhanush Krishna B

doi:10.48165/jlas.2019.1.2.5

Authors

Mallikarjuna G Veterinary Officer, Veterinary Dispensary, Tavarekere, Tumkur, Karnataka Author
Suguna Rao Department of Pathology, Veterinary College, Hebbal, Bangalore-560 024, Karanataka Author
Shridhar N B Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore-560 024, Karnataka Author
Sathyanarayana M L Department of Pathology, Veterinary College, Hebbal, Bangalore-560 024, Karanataka Author
Byregowda S M Joint director, IAH&VB, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka Author
Dhanush Krishna B Research Associate, The Himalayan Drug Company, Bangalore, Karnataka Author

DOI:

https://doi.org/10.48165/jlas.2019.1.2.5

Keywords:

Momordica charantia, streptozotocin, rat, insulin, diabetes mellitus

Abstract

The pathomorphological evaluation of antidiabetic effect of hydroalcoholic extract of Momardica charantia (M. charantia) plant’s fruit pulp was studied in streptozotocin (STZ) induced diabetes in Wistar albino rats against glibenclamide. Hydroalcoholic extract of M. charantia at 200 mg/kg was administered to the diabetic subjects for 45 days. The antidiabetic effect was evaluated by estimation of serum glucose, cholesterol, triglyceride, ALT, AST and serum insulin. Detailed histopathologic evaluation of islets of Langerhans, liver and other organs was performed to assess its pathomorphological effects. The diabetic rats which received the hydroalcoholic extract of the M. charantia fruit pulp showed significant decrease (P≤0.001) in the serum levels of glucose, cholesterol, triglyceride, ALT and AST and the serum insulin was significantly increased (P≤0.001) compared to diabetic control animals. The effect observed was almost comparable to those of glibenclamide. The microscopic evaluation of islets of Langerhans indicated either the regeneration or repair of the affected beta cells and also the extract found to have marked hepatoprotective effect against STZ induced liver injury

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