Two different rat models for cardiac hypertrophy by  constriction of ascending and abdominal aorta

Santhosh Kumar  Sankaran; Ajith Kumar  G S; Binil Raj S S; Rajagopal R

doi:10.48165/jlas.2019.2.1.11

Authors

Santhosh Kumar Sankaran Veterinarian and Officer-in-Charge, Animal Research Facility, Rajiv Gandhi Centre for Biotechnology, Thycaud P.O, Poojappura, Thiruvananthapuram, Kerala, India, Pin -695 014. Author
Ajith Kumar G S Cardiovascular Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thycaud P.O - 695 014. Poojappura, Thiruvananthapuram, Kerala, India, Author
Binil Raj S S Cardiovascular Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thycaud P.O - 695 014. Poojappura, Thiruvananthapuram, Kerala, India Author
Rajagopal R Animal Research Facility,Rajiv Gandhi Centre for Biotechnology, Thycaud P.O - 695 014. Poojappura, Thiruvananthapuram, Kerala, India Author

DOI:

https://doi.org/10.48165/jlas.2019.2.1.11

Keywords:

Atherosclerosis, cardiac hypertrophy, rats, aorta

Abstract

Atherosclerosis is one of the important life style diseases of human beings. There are several animal models in vogue for studying the patho-physiology of Atherosclerosis. It is usually done by inducing pressure overload of aorta. In this study we attempted two different murine models by constriction of thoracic aorta (ascending aorta) and by constriction of abdominal aorta, using metal clips. It was observed that thoracic aorta banding requires expertise, expensive equipment and an increased mortality rate compared to abdominal aorta banding. But the time period for the development of cardiac hypertrophy was lesser in thoracic method (2-4 months) compared to abdominal aorta approach (20-24 months).

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