Effect of vincristine on oral cavity carcinoma in  rhesus monkey (macaca mulatta)

Surender  Singh; Jerald Mahesh  Kumar; Nagarajan  P

doi:10.48165/jlas.2022.5.2.4

Authors

Surender Singh Primate Research Center, National Institute of Immunology, New Delhi Author
Jerald Mahesh Kumar Center for Cellular and Molecular Biology, Hyderabad Author
Nagarajan P Center for Cellular and Molecular Biology, Hyderabad Author

DOI:

https://doi.org/10.48165/jlas.2022.5.2.4

Keywords:

Macaque, Squamous cell carcinoma, Vincristine

Abstract

An adult male rhesus monkey (Macaca mulatta ) presented a malocclusion of teeth/ jaw with slight swelling in the upper mandible in particular on right upper canine with diffused growth in the lower incisor and was showing progressive loss in the weight of the animal. Histopathology of the biopsied tissue confirmed the lesion as Squamous Cell Carcinoma (SCC). The animal was treated with Vincristine sulphate for three consecutive days two weeks apart. During and after treatment, there was gradual reduction in the growth with some changes in hematological parameters and weight. Squamous cell carcinoma is one of the most common oral neoplasia in many species including macaques. Treatment with Vincristine sulphate has a good response to prolong the life of the animal.

Downloads

Download data is not yet available.

References

1. Ettinger SJ, Feldman EC (2004). Textbook of veterinary internal medicine, 6 ed, vol 2. St Louis (MO): Elsevier Health Sciences.

2. Bennett BT, Abee CR, Henrickson R (1998). Nonhuman primates in biomedical research: diseases. 1st Edition. Academic Press.

3. Haddad JL, Dick EJ, Guardado-Mendoza R and Hubbard GB (2009). Spontaneous squamous cell carcinoma in 13 baboons, a first report in a spider monkey, and a review in the nonhuman primate literature. J. Med. Primatol. 38:175–186.

4. Simmons HA and Mattison JA (2011). The incidence of

5. Cianciolo RE and Hubbard GB (2005). A review of spontaneous neoplasia in baboons (Papio spp.). J. Med. Primatol. 34:51–66.

6. Kaspareit J, Friderichs-Gromoll S, Buse E and Haberman G (2007). Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fasicularis) during a 15- year period. Exp. Toxicol. Pathol. 59:163–169.

7. McGavin MD and Zachary JF (2007). Pathologic basis of veterinary disease, 4th ed. St Lois (MO): Elsevier Mosby. 8. McIntosh GH, Giesecke R, Wilson DF and Goss AN (1985). Spontaneous nasopharyngeal malignancies in the common marmoset. Vet Pathol. 22:86–88.

9. Slatter D (2003). Tumors of the mandible, maxilla and calvarium. In: Text Book of Small Animal Surgery. 3rd Ed. Philadelphia: Saunders. Pp. 2488-2492.

10. Murchison EP (2008). Clonally transmissible cancers in dogs and Tasmanian devils. Review. Oncogene. 27: Suppl 2, 19-30.