"What a cool facility!!! " - but how do the inhabitants feel?
DOI:
https://doi.org/10.48165/jlas.2022.5.2.3Keywords:
thermal comfort, CPCSEA, hamsterAbstract
“22±2°C” is a figure imprinted hard and deep into the brain of any facility manager since the very early days of his/her career. The value which got imbibed globally, without much ruckus is however, now a “hot” topic after which scientists and veterinarians in the field of basic laboratory animal science are in hot-trail of. Mice are housed in laboratories at 20–24°C, which is way below their lower critical temperature which is approximately 30°C where the range of their thermoneutral zone (TNZ) is from 26°C-34°C. Hence, housing these animals at lower temperature ranges will increase the thermal stress and has the potential to alter scientific outcomes (Gaskill BN et al., 2012). This is true for rats as well which are housed at 22-24°C; evidently below their lower critical temperature of 26°C. TNZ of pigs weighing from 1 kg to 5 kg on a maintenance diet, housed in groups of 10 pigs per pen, on concrete floor, is 22-32°C and for 40Kg weighing pigs in similar conditions as stated above but for 15 pigs housed per pen is 13-26°C. In simpler terms, the thermal comfort zone of pigs in their various stages of production are 10-21°C or a mature boar, lactating sow and a gestating sow; 24-30°C for a weaner and 32-38°C for a new-born piglet (for which heating up has to be provided) (Stewart and Cabezón, 2016).
Downloads
References
1. National Research Council. Guide for the care and use of laboratory animals. National Academies Press; 2010 Dec. 27.
2. CPCSEA guidelines, 2015; As extracted from the Compendium of CPCSEA 2018.
3. Directive EU. 63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union. 2010 Sep;276(33).
4. Ecker, E. D., & Skelly, A. C. (2010). Conducting a winning literature search. Evidence-based Spine-care J., 1(1), 9–14. doi:10.1055/s-0028-1100887
5. Speakman JR, Keijer J. Not so hot: Optimal housing temperatures for mice to mimic the thermal environment of humans. Mol Metab. 2012;2(1):5–9. Published 2012 Nov 8. doi:10.1016/j.molmet.2012.10.002
6. Jaap Keijer, Min Li, John R. Speakman. What is the best housing temperature to translate mouse experiments to humans? Molecular Metabolism. Volume 25, July 2019, Pages 168-176.
7. Fischer AW, Cannon B, Nedergaard J. Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study. Mol Metab. 2018;7:161– 170. doi:10.1016/j.molmet.2017.10.009