UCFM as the forerunner in the field of Laboratory Animal Science in Sri Lanka
DOI:
https://doi.org/10.48165/jlas.2023.6.1.5Keywords:
museum, AlthoughAbstract
Animals have been models for humans since the dawn of medicine as per the first medical handbook ‘Corpus Hippocraticum’ (around 400 B.C). In an era where no anaesthetic agents were identified, live animals such as dogs, pigs and monkeys were the subjects for vivisections to study human anatomy. Reverend Stephen Hales (1677–1761) inserted a brass pipe into a major blood vessel in the neck of a live horse through which a glass tube was sent and introduced the concept of blood pressure to the scientific fraternity (van Zutphen, 2001; Lewis, 1994; Felts, 1977). Similar to these, different animals have been the models for development of many fields of medicine especially for the benefit of humans. The objective of this article is to describe the role played by the Faculty of Medicine, University of Colombo (UCFM) as the forerunner in laboratory animal science in Sri Lanka to facilitate laboratory animal use in medical education, research, ethics and laboratory animal science education.
Downloads
References
1. Delwatta S L, Gunatilake M, Baumans V, Seneviratne M D, Dissanayaka M L B, Batagoda S S, Udagedara A H, Walpola P B (2018). Reference values for selected haematological, biochemical and physiological parameters of Sprague-Dawley rats at the Animal house, Faculty of Medicine, University of Colombo, Sri Lanka. Journal of Animal Models and Experimental Medicine, 1(4): 250-
254.
2. Felts J H (1977). Stephen Hales and the measurement of blood pressure. North Carolina Medical Journal. 38(10): 602–3.
3. Gunatilake M, De Mel T, Fernando C, Angunawela P, de Tissera A, Welihinda J (1996). Time of onset and mechanism of nephrotoxicity after envenoming rats with Russell’s viper venom and cobra venom. Journal of the Ceylon College of Physicians. 29(1): 29-35
4. Gunatilake M, Jayakody R L, Angunawela P, de Tissera A (2003). Direct nephrotoxic effects produced by venoms of Sri Lankan cobra, Russell’s viper and hump nosed viper. The Ceylon Journal of Medical Science. 46(2): 61-66.
5. Gunatilake M, Lokuhetty M D S, Bartholameuz N A, Edirisuriye D T, Kularatne M U, Date A (2012). Polpala (Aerva lanata): Its effects on the structure and function of the urinary tract. Pharmacognosy Res. 4(4): 181-188.
6. Gunatilake M. President’s Message and SLALAS Inaugural workshop. In. SLALAS Newsletter. 2013;1(1).
7. Gunatilake M, Busquet F, Akbarsha M A (2014). Alternatives Initiative in Sri Lanka: Pre- and Post Conference Workshops at the Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science. Altex. 31(2): 224-226.
8. Gunatilake M (2018a). History and development in laboratory animal science in Sri Lanka. Animal Models and Experimental Medicine, 1(1): 3-6. https://doi.org/10.1002/ ame2.12003.
9. Gunatilake M (2018b). Report on First Certificate Course on Applied Physiology of Pain, Analgesia, Anaesthesia and Euthanasia for laboratory animals held in Sri Lanka. Adv Physiol Educ. 42(2): 263-266. doi:10.1152/
advan.00019.2018.
10. Guidelines for Ethics Review of Research Proposals involving Animals in Sri Lanka. (2009). Ed: Dissanayake D H W, Gunatilake M, Thureisingham C and Jayamanne N M M. Forum of Ethics Review Committees of Sri Lanka and Ethics Review Committee, Faculty of Medicine, University of Colombo.
11. Herath H M D R, Gunatilake M, Lokuhetty D, Wijayabandara J (2005). A preliminary investigation on the effects of polpala (Aerva Lanata) on the structure and function of urinary tract of rats. The Ceylon Journal of Medical Science. 48(2): 33-41.
12. Lewis O (1994). Stephen Hales and the measurement of blood pressure. Journal of Human Hypertension. 8(12): 865–71.
13. Proceedings of the Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science (SLALAS). 2014.
14. Ranasinghe P, Perera S, Gunatilake M, Abeywardane E, Gunapala N, Premakumara S, Perera K, Lokuhetty D, Katulanda P (2012). Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in Sprague-Dawley rats. Pharmacognosy Res. 4(2): 73–79.
15. Samanmali B L C, Gunatilake M, Guneratne R D, Perera T R K (2014). Hypoglycaemic effect of methanolic extract of Aporusa lindleyana leaves on rats. J. Natn. Sci. Foundation Sri Lanka. 42(2): 129-135.
16. Seneviratne K N, Peiris O A (1969). The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats. J Neurol Neurosurg Psychiatry. 32(5): 462-469.
17. Seneviratne K N (1972). Permeability of blood nerve barriers in the diabetic rat. J Neurol Neurosurg Psychiatry. 35(2): 156-162.
18. Seneviratne K N, Weerasuriya A (1974). Nodal gap substance in diabetic nerve. J Neurol Neurosurg Psychiatry. 37(5): 502-513.
19. SLALAS Newsletters – 2014;2(1&2), 2015;3(1&2), 2016;4(1) and 2017;5(1).
20. van Zutphen L F M (2001). Introduction. In: Principles of Laboratory Animal Science, 2nd Edition, Ed: van Zutphen L F M, Baumans V, Beynen A C. Elsevier Science B.V. Amsterdam, The Netherlands. pp 1-10.
21. Wijewickrama E S, Kurukulasooriya I, Gunatilake M, Amarathunga A H P, Gnanathasan A, Gawarammana I, Isbister G K (2018). Determination of the sub-lethal nephrotoxic dose of Russell’s viper (Daboia russelii)
venom in Wistar rats. Toxicon, 152: 43-45. https://doi. org/10.1016/j.toxicon.2018.07.023