Sub chronic toxicity study of Fusarium xylarioides culture  filtrate from ground nut hay in rats

Vinay T; Shridhar N B; Narayanaswamy  H D; Shrikrishna  I; Jayakumar  K

doi:10.48165/jlas.2019.1.1.11

Authors

Vinay T Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore 560 024, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka, India. Author
Shridhar N B Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore 560 024, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka, India. Author
Narayanaswamy H D Department of Veterinary Pathology ,Veterinary College, Hebbal, Bangalore 560 024, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka, India. Author
Shrikrishna I Departement of Veterinary Microbiology Veterinary College, Hebbal, Bangalore 560 024, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka, India. Author
Jayakumar K Department of Veterinary Pharmacology and Toxicology,Veterinary College, Hebbal, Bangalore 560 024, Karnataka Veterinary, Animal and Fisheries Sciences University, Karnataka, India. Author

DOI:

https://doi.org/10.48165/jlas.2019.1.1.11

Keywords:

sub chronic toxicity, rat, Fusarium xylarioides, groundnut hay

Abstract

Sub chronic toxicity study of culture filtrate of Fusarium xylarioides isolated from the fungal contaminated ground nut hay was carried out in rats. The fungi was isolated from the contaminated groundnut hay which caused mycotoxicosis in cross bred cattle, exhibited the clinical signs of colic, tenesmus, ruminal atony, anorexia, bleeding from nostrils, rectum and fly bite site. The rats were gavaged with culture filtrate at the dose level of 0.25, 0.5, 1 and 2 ml daily for 90 days. Clinical signs observed were diarrhea, weakness, severe arching of back, swollen forehead and conjunctival hemorrhage. Cutaneous hemorrhagic patches on back, scrotum, abdomen, ears and legs region seen. There was a significant increase (P ≤ 0.05) in serum concentrations of creatinine, urea nitrogen, ALT and AST indicated the renal and hepatic damage which was confirmed by histopathology. There were lesions in brain and GI tract of the treated rats. The present study indicated the toxic feature of the culture filtrate of Fusarium xylarioides isolated from ground nut hay.

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