GC-MS, anti-oxidant, anti diabetics and anti-fungal potential of dye extract obtained from Tectona grandis L. leaves
DOI:
https://doi.org/10.48165/jefa.2024.19.01.8Keywords:
Tectona grandis, natural dye, anti-fungal, anti-oxidant, anti-diabeticsAbstract
Tectona grandis is an important dye-producing tree that is used as a colouring agent in the textile and food industries. The leaves of Tectona grandis are used to treat anuria, urinary retention, bronchitis, leukoderma, dysentery, stomach pain, and it can also stimulate hair growth. Antifungal, in vitro anti-oxidant, anti-diabetics assay of methanol solvent extracts obtained from the leaves of Tectona grandis (TG) were investigated. The dye extraction yield was higher in dye extracts extracted using ultrasonication (5.8%), followed by boiling (4.2%). Methanolic extract had the highest DPPH IC50 of 49.06±0.93 and metal chelating activity in teak dye extract of 82.36±0.19. Methanolic extract inhibited á-amylase strongly, with an IC50 of 39.41±0.67. Plant dye extract demonstrated significant antifungal activity against C. albicans (8.25±0.49), A. fumigatus (6.30±0.41), C. glabrata (6.25±0.49), and A. flavus (5.45±0.44) at higher concentrations, respectively. The result of present investigation proved that methanolic extract of T.grandis leaves could be used as a promising natural antioxidant with potential diabetic activity and antifungal properties. So, the dye obtained from T.grandis might be used as a therapeutic agent in textile and food industry.
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Badarinath, A. V., RAo, K. M., Chetty, C. M. S., Ramkanth, V., Rajan, T. V. S. and Gnanaprakash, K. 2010. A review on in vitro antioxidant methods: comparisons, correlations and considerations. International Journal of Pharm Tech Research, 2: 1276–1285.
Blois, M.S. 1958. Antioxidant determinations by the use of a stable free radical. Nature, 29: 1199 – 1200.
chemistry and pharmacological profile. Pharmacognosy Review, 3: 181.
Gracelet, R.J. 2014. Drug discovery approach on Tectona grandis Linn. leaves against apicomplexan plasmodium and wound links its ethnopharmacological validation and pharmacognostical relevance [Masters Thesis]. Dr. M. G. R. Medical University, Chennai.
Gupta, D., Chandrashekar, Richard, Yogendra, L. and Gupta, N. 2012. In-vitro antidiabetic activity of stem bark of Bauhinia purpurea Linn. Der Pharma Lett, 4: 614–661.
Harbone, J.B. 1998. Phytochemical Methods. (3rd ed.). Chapman and Hall, London.
Ivanova, A., Delcheva, I., Isvetkova, I., Kujumgiev, A. and Kostava, I. 2002. GCMS analysis and anti-microbial activity of acidic tractions obtained from peonies peregvine termifolia roots. Journal Naturtor School, 57:624-628.
Khare, C.P. 2007. Indian Medicinal Plants: An Illustrated Dictionary. Springer Verlag. Heidelberg, 649p.
Lailatul, Qadariyah, Mahfud, Endah Sulistiawati and Swastika, Prima. 2018. Natural dye extraction from teak leves (Tectona Grandis) using ultrasound assisted extraction method for dyeing on cotton fabric. MATEC Web of Conferences, 156, 05004.
Liu, H., Qiu, N., Ding, H., Yao, R. 2008. Polyphenols contents and antioxidant capacity of 68 Chinese herbals suitable for medicinal or food uses. Food Research International, 41: 363- 370.
Lordan, S., Smyth, T.J., Soler-vila, A. et al. 2013. The ±- amylase and ±- glucosidase inhibitory effects of Irish seaweed extracts. Food Chemistry. 141: 2170-2176.
Mathur, P., George, Ruby and Mathur, Ananya. 2020. Anthocyanin: a revolutionary pigment for textile industry. Amity Institute of Biotechnology, Amity University, Uttar Pradesh, 5p.
Narkhede, M. B., Ajimire, P., Wagh, V., Manoj Mohan, A. E. and Shivashanmugam, A. T. 2011. In- vitro antidiabetic activity of Caesalpina digyna (R.) methanol root extract. Asian Journal of Plant Science and Research, 2: 101-106.
Parveen, A., Babbar, R., Agarwal, S., Kotwani, A. and Fahim, M. 2012. Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenolinduced chronic heart failure in rats. Journal of Cardiovasc Pharmacol Ther.
Prabhu, K.H. and Bhute, A.S. 2012. Plant based natural dyes and mordant: a review. Journal of Natural Product and Plant Resources, 2: 649-664.
Purushotham, K.G., Arun, P., Jayarani, J.J., Vasanthakumari, R. and Chamundeeswari, D. 2010. In-Vitro antibacterial and antifungal assay of Tectona grandis- a screening study. Research Journal of Pharmacognosy and Phytochemistry, 2: 57- 60.
Reddy, G.A., Joy, J.M., Mitra, T., Shabnam, S. and Shilpa, T. 2012. Nano silver – a review. International Journal of Advice Pharmacology, 2: 9-15.
Sandeep and Ghosh, Sumit. 2020. Chapter 12- Triterpenoids: Structural diversity, biosynthetic pathway and bioactivity. Studies in Natural Products Chemistry, 67: 411-461.
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K. and Perry, G. 2000. Oxidative stress in Alzheimer’s disease. Biochim Biophys Acta, 1502: 139-144.
Sofowara, A. 1993. Medicinal plants and traditional medicine in Africa. Spectrum Books Ltd, Ibadan, Nigeria, 289p.
Sultana, B., Anwar, F. and Przybylski, R. 2007. Antioxidant activity of phenfolic components present in barks of barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica and Eugenia jambolana Lam. trees. Food Chemistry, 104: 1106-1114.
Trease, G.E. and Evans, W.C. 1989. Phenols and phenolic glycosides. In: Textbook of Pharmacognosy (12th ed.). Balliese, Tindall and Co. Publishers, London, 343-383.
Velavan, S. 2011. Free radicals in health and diseases - a mini review. Pharmacologyonline Newsletter, 1: 1062-1077.
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