A Critical Review on Guduchi (Tinospora cordifolia [willd.] miers) and its Medicinal Properties

Anshu; Sarvesh Kumar  Singh; Kshipra Rajoria

doi:10.48165/IRJAY.2024.70606

Authors

Anshu PG Scholar, Department of Panchakarma, National Institute of Ayurveda, Jaipur, Rajasthan, India. Author
Sarvesh Kumar Singh Associated Professor, Department of Panchakarma, National Institute of Ayurveda, Jaipur, Rajasthan, India. Author
Kshipra Rajoria Assistant Professor, Department of Panchakarma, National Institute of Ayurveda, Jaipur, Rajasthan, India Author

DOI:

https://doi.org/10.48165/IRJAY.2024.70606

Keywords:

Amrita, Ayurveda, Therapeutic potential, Tinospora cordifolia

Abstract

Introduction: First of all, Tinospora cordifolia, sometimes referred to as “Amrita” or “Guduchi,” is a crucial medication utilized in Indian Systems of Medicine and has been for ages. The Sanskrit term “guduchi” means “which protects the body from diseases.” This herb is also known by the name “Amrita,” which in Hindu mythology alludes to the celestial nectar. Aim: This well-known Indian bitter is recommended for fevers, diabetes, dyspepsia, jaundice, skin conditions, kidney issues, persistent diarrhea, and dysentery. Leprosy, helminthiasis, rheumatoid arthritis, and cardiac problems have all been shown to benefit from it. It is a significant medication that is utilized in a variety of preparations, including Swarasa, Ghrita, Satva, Tail, etc. Material and Methods: For this review article, Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Ashtanga Sangraha, Bhavprakash Nighantu, Raj Nighantu, Dhanvantari Nighantu, Shaligrama Nighantu, Priya Nighantu, Kaiydev Nighantu, Madanpal Nighantu, Shodhal Nighantu. Results: It has long been recognized that the T. cordifolia plant possesses strong therapeutic, medicinal, healing, and soothing properties. Discussion: Guduchi’s anti-toxic, anti-inflammatory, antipyretic, and anti-oxidant qualities make it a highly promising medicinal herb. In addition, there is no proof that Guduchi contains any harmful substances or adverse effects, demonstrating its safety. Conclusion: T. cordifolia, often known as Giloy, is an herb with medicinal characteristics that can prevent many diseases or abnormalities by naturally boosting immunity in human bodies. These properties are confirmed by the therapeutic and safety aspects research included in this review. Herbal and traditional medicines have a long history and are widely used in India. Natural medicines are becoming more and more important in clinical research these days. In the enormous collection of significant Guduchi (Tinospora cordifolia), one of the medicinal

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References

Chunekar KC, editor. Bhavamishra. Bhavaprakasha Nighantu-Hindi Commentary. Varanasi: Chaukhumba Bharati Academy; 2002. p. 47-9. 2. Radhakantadev R. Shabdhakalpadruma. 3rd ed. Delhi: Naga Publishers; 2006. p. 33-9.

Taranatha TV. Vachaspatyam: A Comprehensive Sanskrit Series. 1st ed. Calcutta: Choukhamba Publication; 1873-84. p. 17. 4. Available from: https://www.researchgate.net/publication/274701448_ therapeutic_vistas_of guduchi_tinospora_cordifoila_a_medico historical_memoir [Last accessed on 2024 Apr 24].

Sharma PC, Yelne MB, Dennis TJ. Data Base on Medicinal Plants used in Ayurveda. Vol. 3. New Delhi: Documentation and Publication Division, Central Council for Research in Ayurveda and Siddha; 2001. p. 256.

Hegde PL. A Textbook of Dravyaguna Vijnana. Vol. 2. New Delhi: Chaukhambha Publications; Vol. 2. p. 309.

Government of India, Ministry of Health and Family Welfare. Ayurvedic Pharmacopoeia of India. Vol. 1.16. New Delhi: Government of India, Ministry of Health and Family Welfare; 1999. p. 214.

Singh J, Sinha K, Sharma A, Mishra NP, Khanuja SP. Traditional uses of Tinospora cordifolia (Guduchi). J Med Aromat Plant Sci 2003;25:748-51.

Chunekar KC, Pandey GS. Guduchyadi Varga. Bhavprakash Nighantu. Varanasi: Chaukhambha Bharati Academy; 2006. p. 269. 10. Tripathi RD. Astanga Samgraha (Sutrasthana). Varanasi: Chaukhambha Sanskrit Pratisthan; 2006. p. 142-315.

Tripathi B. Charak Samhita PartI. Varanasi: Chaukhambha Surbharati Prakashan; 2003. p. 454.

Tripathi I. Raj Nighantu. Varanasi: Chaukhambha Krishnadas Academy; 2003. p. 31.

Tripathi I. Arkaprakash. Tritiya Shatak. Varanasi: Chaukhambha Krishnadas Academy; 2006. p. 45.

Bhatta KR, Bhatta RK, Swami LR. Siddha Bhaisajya Mani Mala: Vaishwanara Hindi Commentary. 3rd ed. Vol. 3. Varanasi: Chaukhambha Krishnadas Academy; 2009. p. 31.

K Shodhal. “Shodhal Nighantu”. Baroda: University Publications Sales Unit. Anonymous; 1978. p. 101.

Pandit RP. “Madanpal Nighantu”. Mumbai: Khemraj Srikrishnadas Prakashan; 1998. p. 8.

Sharma PV, Sharma GP. “Kaiyadeva Nighantu”. Varanasi: Chaukhambha Orientalia; 2006. p. 5.

Kamat SD. “Dhanvantari Nighantu”. Delhi: Chaukhambha Sanskrit Pratisthan; 2002. p. 1.

Harishankar SL. Shaligram Vaishya Krit Shaligram Nighantu. 3rd ed. Mumbai: Khemraj Shri Krishna Das Prakashan; 1912. p. 251-3. 20. Sharma AR. Sushrut Samhita: Sushrutvimarshini Hindi Commentary

along with Special Deliberation etc. Part. Varanasi: Chaukhambha Surbharati Prakashan; 2000. p. 419.

Sharma AR. Sushrut Samhita: Sushrutvimarshini Hindi Commentary along with Special Deliberation etc. Part II. Varanasi: Chaukhambha Surbharati Prakashan; 2001.

Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Indian J Pharmacol 2003;35:83-91.

Singh J, Sinha K, Sharma A, Mishra NP, Khanuja SP. Traditional uses of Tinospora cordifolia (Guduchi). J Med Aromat Plant Sci 2003;25:748-51.

DerMarderosian A, Beutler A, John A, editors. The Review of Natural Products: The Most Complete Source of Natural Product Information. 4th ed. Pennsylvania, USA: Lippincott Williams and Wilkins; 2005.

Jagetia GC, Rao SK. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol Pharm Bull 2006;29:460-6.

Singh SM, Singh N, Shrivastava P. Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in atumor-bearing host. Fitoterapia 2006;77:1-11.

Singh N, Singh SM, Shrivastava P. Effect of Tinospora cordifolia on the antitumor activity of tumor associated macrophages-derived dendritic cells. Immuno pharmacol Immuno Toxicol 2005;27:1-14.

Mittal A, Singh RP. Anticancer and immunomodulatory properties of Tinospora. In: Ranawat KG, editor. Herbal Drugs: Ethnomedicine to Modern Medicine. Berlin Heidelberg: Springer; 2009. p. 195.

Jagetia GC, Nayak V, Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Lett 1998;127:71-82.

Jagetia GC, Rao SK. Evaluation of cytotoxic effects of dichloromethane extract of guduchi (Tinospora cordifolia dichloromethane extract of guduchi (Tinospora cordifolia Miers ex Hook F and THOMS) on cultured HeLa cells. Evid Based Complement Alternat Med 2006;3:267-72.

Karkal YR, Bairy LK. Safety of aqueouse of Tinospora cordifolia (Tc) in healthy volunteers: A double blind randomised placebo controlled study. Iran J Pharmacol Therap 2007;6:59-61.

Prince PS, Kamalakkannan N, Menon VP. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats. Acta Pol Pharm 2004;61:283-7.

Mathew S, Kuttan G. Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J Exp Clin Cancer Res 1997;16:407-11.

Stanely Mainzen Prince P, Menon VP. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother Res 2001;15:213-8.

Grover JK, Rathi SS, Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens Miers ex Hook F and THOMS) on cultured HeLa cells. Evid Based Complement Alternat Med 2006;3:267-72.

Raghunathan K, Sharma PV. The aqueous extract of T. cordifolia caused reduction of blood sugar in alloxan induced hyperglycemic rats and rabbits. J Res Ind Med 1969;3:203-9.

Dhaliwal KS. Method and Composition for Treatment of Diabetes. US Patent No 5886029; 1999.

Leyon PV, Kuttan G. Effect of Tinospora cordifolia on the cytokine

Anshu, et al.: Guduchi (Tinospora cordifolia) and its medicinal properties 2024; 7(6):34-43 39

profile of angiogenesis-induced animals. Int Immunopharmacol 2004;4:1569-75.

Purandare H, Supe A. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: A prospective randomized controlled study. Indian J Med Sci 2007;61:347-55.

Asthana JG, Jain S, Mishra A, Vijaykant MS. Evaluation of antileprotic herbal drug combinations and their combination with Dapsone. Indian Drugs 2001;38:82-6.

Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity

of pepticare: A herbomineral formulation. Phytomedicine 2005;12:264-70.