SHRAMAHARA MAHAKASHAYA OF CHARAKA SAMHITA – A PROMISING SUPPLEMENT FOR IMMUNOMODULATION – A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.48165/Keywords:
–Immuno-modulation, anti-fatigue formula, shramahara mahakashayaAbstract
Immuno-modulation or modification of the immune responses towards wellbeing is incorporated as vyadhik shamatva, swasthya (wellbeing), bala(strength) and ojas in Ayurveda. Shrama (fatigue) is the main feature of balakshaya (Strength depletion), ojahkshaya (condition of depleting immunity) as well as rasa, asthi and shukradhatu kshaya (tissue depletions). Thereby, shrama and vyadhik shamatva
have a coexisting relation. Acharya Charaka has collectively mentioned 10 drugs as shramahara mahakashaya which works effectively in shrama. Ingredients of shramahara mahakashaya are rich in nutrients, antioxidants and also have proven effects on anxiety, and in immuno-modulation. Hence, this systematic review has been carried out to find the efficacy of shramahara mahakashaya in immuno-modulation. The study was carried out using thorough analysis of various Ayurveda classical texts as well as available modern literature and collected data & observations were presented in a scientific manner. The review will be beneficial to
understand and to modify the host immunity according to Ayurveda concepts.
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References
Baylor College of medicine, Texas: university. Emerging infectious diseases [internet].[accessed on 03.09.2019] available from:
https://www.bcm.edu/departments/molecular-virology-and-microbiology/emerging infections-and-biodefense/emerging-infectious-diseases
Mrthy SKR. Sushruta samhita (Text. English translation, notes, appendices, and index),volI. Re-print. varanasi: Chaukambha Orientalia;2012. 1.P- 8
Sri Taranatha Tarka vachaspati. Vachaspatyam (A comprehensive Sanskrit Dictionary).Varanasi-1:Chaukhambha Sanskrit Series;1962.P- 2362.
Yadavji Trikamji Acharya .Charaka Samhita, Revised by Charaka and Dridhabala with the Ayurveda dipika commentary of Chakrapani datta. 5th edition. New Delhi: Munshiram Manoharlal Pvt Ltd;1992. P-138.
YadavJi TrikamJi. Sushruta samhita with Nibandha sangraha commentary of Dalhana. Varanasi. Chaukambha Sanskrit sansthan, Re-print. 2014.P-470
Shrama R.K, Dash B. Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-427
Shrama R.K, Dash B. Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-565
Shrama R.K, Dash B. Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.III. Re-print. Varanasi: Chowkamba Sanskrit series office;2019.2018.P-162
Mrthy SKR. Sushruta samhita (Text. English translation, notes, appendices, and index), vol I. Re-print. varanasi: Chaukambha Orientalia;2012.Sutra.P-104.
Maharshi Sushruta. Sushruta Samhita. Vol I [KK Thakaral. Trans].Varanasi: Chaukambha Orientalia E- Samhita). 2016. P-168-169
Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya, Varanasi: Chaukambha Sanskrit Santhan; 2013. P-71
Tripati B. Ashtanga hrdayam of Srimadha vagbhata edited with Nirmala Hindi commentary along with special deliberation etc.New Delhi, Chaukambha Sanskrit pratishthan.2019;P-168
Shrama R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi: Chowkamba Sanskrit series office;2019. P-221
Shrama R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019. P.98
Shrama R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-68-69
Sharma R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi: Chowkamba sanskrit series office;2019. P.101
Manju K, Devi D. Role of rasayana as immunomodulator in diseases. International Ayurvedic Medical Journal. 2015 Aug;3(8):2536-2543
Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya. Varanasi: Chaukambha Sanskrit Santhan; 2013. P- 470
Adrianne Bendich. Physiological role of antioxidants in the immune system. Journal of dairy science. 1993 Sep; 76(9):2789-2794
Mahajon B.An experimental evaluation of anti-fatigue activity of Shramahara mahakashaya and its applicability in sports [PhD thesis].Post graduate department of Dravyguna Vigyana, National Institute of Ayurveda, Jaipur. Dr. Sarvaepalli Radhakrishnan Rajasthan Ayurveda University.2018
Mahajon B., Rama Murthy A., Relevance of shramahara mahakashaya (An anti-fatigue formulation) in sports medicine2018:Journal of scientific innovation and research,2018;7(1):15-17
Sharma R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on CakrapaniDatta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P.26-27
Sharma R.K, Dash B. Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi: Chowkamba sanskrit series office;2019. P.101
Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya. Varanasi: Chaukambha Sanskrit Santhan; 2013. P-71
Sharma R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.V.Varanasi: Chowkamba sanskrit series office;2019. P.26-27
Mukherjee S, Das SK, Vasudevan DM. Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice. Indian Journal of biochemistry and biophysics. 2012 Oct;49(5):379-85
Karasawa K, Uzuhashi Y, Hirota M, Otani H. A Matured Fruit Extract of Date Palm Tree (Phoenix dactylifera L.) Stimulates the Cellular Immune System in Mice.Journal of Agricultural and Food Chemistry. 2011 Sep; 59(20):11287-93,DOI: 10.1021/jf2029225
Singh MK, Das BK, Patidar P. The effect of methanolic extract of Buchanania lanzan Spreng seeds on hematological indices. Indian Journal of Pharmacology. 2016;48(2): 214-215
Chen J, Liu X, Li Z, Qi A, Yao P, Zhou Z, Dong TTX., Tsim KWK. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. Evidence-based complementary and alternative medicine.2017 June 7
(3019568):10
Laily N, Harahap AR , Aji GK, Sukarti I , Ascobat P, Wijayanti RDE. Potential Use of Pomegranate (Punica granatum) Extract as an Immune-Stimulant Based on in vitro and in vivo Models. Mal J Nutr. 2016; 22(2): 279 – 287
Yang XM, Yu w, Ou ZP, Ma HL, Liu WM, Ji Xl. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plants food humnutri.. 2009 Jun;64(2):167-73
Singh S, Yadav AK. Evaluation of immunomodulatory activity of Grewia asiatica in laboratory animals. Journal of Chemical and Pharmaceutical Research, 2014, 6(7):2820- 2826
Awais A, Akhtar M, Muahmmad M, UlHaq A, Anwar MI. Immunotherapeutic effects of some sugar cane (Saccharumofficinarum L.) extracts against coccidiosis in industrial broiler chickens. Experimental parasitology. 2011 Jun;128(2):104-10. doi: 10.1016/j.exppara.2011.02.024. Epub 2011 Feb 24.
Han L, Meng M, Guo M, Cheng D, Shi L, Wang X, Wang C. Immunomodulatory activity of a water-soluble polysaccharide obtained from highland barley on immunosuppression mice models. Food & Function.2018 Dec;10 (1):DOI: 10.1039/C8FO01991F
Yang LC, Hsieh CC, Lin WC. Characterization and immunomodulatory activity of rice hull polysaccharides. Carbohydrate Polym. 2015 Jun 25;124:150-6. doi: 10.1016/j.carbpol.2015.02.025.
Sharma R.K, Dash B., Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.II.Varanasi:Chowkamba sanskrit series office;2018. P.420-421
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