Anukta Dravya Adhyayan – Stevia Rebaudiana
DOI:
https://doi.org/10.48165/Keywords:
Stevia rebaudiana, Rasa, Virya, Vipaka, anti-tumorous activityAbstract
The emergence of chemical molecules has been a blessing for combating several diseases, but it has paved the way for troublesome situations such as various adverse effects, the emergence of resistance and so on. Various research has been underway on new molecules to find out the least effects and having a better potency is currently on its way and more concentration is being given upon traditional plants in order to avoid these aforementioned problems. Medicinal plants have been recognized to have potential drug uses. Any dysregulation is avoided due to the sweetness imparted by its glycosides and is known by it. The evaluation by phytochemical studies concluded the existence of tannins, alkaloids, glycosides, saponins, sterols, triterpenes with various potentials.[5][6] The purpose of this review is to understand the medicinal potential of stevia and its acceptance as a significant raw material for human diet.
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References
Adesh AB, Gopalakrishna B, AkkiKusum S, Tiwari OP (2012) An over- view on stevia: a natural calorie free sweetener. Int J Adv Pharma BiolChe 1: 362-368.
Yadav AK, Singh S, Dhyani D, Ahuja PS (2011) A review on the improve-ment of stevia [Stevia rebaudiana (Bertoni)]. Can J Plant Sci 91: 127- 130.
Braz-De-Oliveira A, Goncalves RAC, Chierrito TPC, Souza L, Gorin PAJ, et al. (2011) Structure and degree of polymerisation of fructooligosac charides present in roots and leaves of stevia rebaudiana bertoni. FoodChem 129(2): 305-311.
Cacciola F, Delmontea P, Jaworska K, Dugo P, Mondello L, et al. (2011) Employing ultra-high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis ofstevia rebaudiana extracts. J Chromat 1218: 2012-2018.
Raut D, Aruna K (2017) Antimicrobial activity of stevia rebaudiana against antibiotic resistant ESBL producing uropathogens and evalua- tion of its antioxidant activity. Int J Adv Res Biol Sci 4: 110-118.
Miranda-Arambula M, Olvera-Alvarado M, LoboSanchez M, Perez-Xo- chipa I, Rios-Cortes AM (2017) Antibacterial activity of extracts of ste- via rebaudiana bertoni against staphylococcus aureus, staphylococcus
epidermidis and pseudomonas aeruginosa. J Med Plant Res 11: 414-418.
Goyal S, Samsher R (2010) Stevia a bio sweetener: a review. Int J FoodSci Nutr 61: 1-10.
López-Carbón V, Sayago A, González Domínguez R, Fernández-Reca- males Á (2019) Simple and efficient green extraction of steviol glyco- sides from stevia rebaudiana leaves. Food 8(9): 402-406.
Kroyer G (2010) Stevioside and stevia-sweetener in food, application,stability and interaction with food ingredients. J verb lebensm 5: 225-229.
Marcinek K, Krejpcio Z (2015) Stevia rebaudiana bertoni–chemical composition and functional properties. Acta Sci Pol Technol Aliment 14(2): 145-152.
Shakya AK (2016) Medicinal plants: future source of new drugs. Int J Herbl Med 4: 59-64.
Srivastava S, Chouhan DES, Chawla P (2016) Proximate and phyto- chemical analysis of stevia leaves powder. Int Ayurved med J 4: 2476-2480.
Gasmalla MAA, Yang R, Issoufou A, Hua X (2014) Nutritional composi- tion of stevia rebaudiana bertoni leaf: effect of drying method. Trop J Pharm Res 13: 61-65.
Kobus-Moryson M, Gramza-Michalowska A, Kobus-Cisowska J, KorczakJ (2014) Contents of selected elements in extracts from sweet leaf (ste via rebaudiana Bertoni). Probl Hig Epidemiol 95: 445-448.
Ahmed SR, Mukta S (2017) Review on stevia rebaudiana as a non-ca- loric natural sweetener producing plant. J Syl Agric Uni 4: 15-25.
Shuvo MMA, Al–Mamun M, Chowdhury T, Absar N, Hasanuzzaman M (2015) An assessment of major nutritional components and some sec- ondary metabolites of in vitro propagated stevia rebaudiana (cultured in Bangladesh) plant leaves dry powder. Int J Applied Sci Biotechnol 3: 721-26.
Gupta E, Purwar S, Sundaram S, Rai GK (2013) Nutritional and thera- peutic values of stevia rebaudiana: a review. J Med Plant Res 7: 3343- 53.
Escutia-López KN, Sánchez-Pardo ME (2019) A comprehensive reviewon the nutritional and therapeutical aspects of stevia rebaudiana ber
toni. J Appl Biotechnol Bioeng 6: 297-302.
Salehi B, López MD, Martínez-López S, Victoriano M, Sharifi-Rad J, et al. (2019) Stevia rebaudiana bertoni bioactive effects: from in vivo to clinical trials towards future therapeutic
approaches. Phytotherap Res33(11): 2904-2917.
Shannon M, Rehfeld A, Frizzell C (2016) In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener stevia. Mol cell endocrinol 427: 65-72.
Singh DP, Kumari M, Prakash HG, Rao GP, Solomon S (2019) Phyto- chemical and
pharmacological importance of stevia: a calorie free nat-ural sweetener. Sugar Tech 21: 227-34.
Ahmad U, Ahmad RS (2018) Antidiabetic property of aqueous extract of stevia rebaudiana bertoni leaves in streptozotocin-induced diabetes in albino rats. BMC Compl Alter med 18: 179- 182.
Scaria A, Kamath JV, Chakraborty M (2017) Antihyperglycemic, Anti- oxidant, Anti hyperlipidemic & nephroprotective effect of stevioside in diabetic rats. Int J Ayurved Med 8: 178-813.
Ilić V, Vukmirović, Tilinović N, Čapo I, Arsenović M, Mili ašević B (2017) Insight into anti-diabetic effect of low dose of stevioside. Biomed Phar-maco 90: 216-221.
Prata C, Zambonin L, Rizzo B, Maraldi T, Angeloni C, et al. (2017) Gly- cosides from stevia rebaudiana bertoni possess insulin mimetic and antioxidant activities in rat cardiac fibroblasts. Oxidat med cell longev11: 140-148.
Aghajanyan A, Movsisyan Z, Trchounian A (2017) Antihyperglycemic and antihyperlipidemic activity of hydroponic stevia rebaudiana aque- ous extract in hyperglycemia induced by immobilization stress in rab- bits. BioMed Res int 10: 120-123.
Assaei R, Mokarram P, Dastghaib S, Darbandi S, Darbandi M, et al. (2016) Hypoglycemic effect of aquatic extract of stevia in pancreas of diabetic rats: PPARγ-dependent regulation or antioxidant potential. Avi J Med
Biotechnol 8: 65-69.
Bayat E, Dastgheib S, Egdar S, Mokarram P (2017) Effect of the aquat- ic extract of stevia on the serum level of interleukin-6 in streptozoto cin-nicotinamide induced diabetic rats. Shiraz E Med J 18: 160-170.
Chavushyan VA, Simonyan KV, Simonyan RM, Isoyan AS, Simonyan GM, et al. (2017) Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of
metabolic disorders caused by fructose. BMC Compl Alter Med 17(1): 540-543.
Najafian S, Moradi M (2017) Polyphenolic compounds (HPLC analysis) and antioxidant activity of stevia rebaudiana (Asteraceae) by FRAP and DPPH assay in greenhouse and free space condition. Int J Farm Allied Sci 6: 49-55.
Mohammad AM (2018) In vitro determination of total phenolics, fla- vonoids and free radical scavenging activities of stevia rebaudiana dry leaves powder in different solvents extract. EC Nutr 13: 71-78.
Yücesan B, Gurel E (2018) Hydrogen peroxide-induced steviol glyco- sides accumulation and enhancement of antioxidant activities in leaf tissues of stevia rebaudiana
bertoni. Sugar Tech 20: 100-104.
Ruiz-Ruiz JC, Moguel-Ordoñez YB, Matus Basto AJ, SeguraCampos MR (2015) Antidiabetic and antioxidant activity of stevia rebaudiana ex- tracts and their incorporation into a potential functional bread. J Food Sci Technol 52: 7894-7903.
Li XY, Lu WM, Shen WF, Wu Y, Liu YP, et al. (2017) Growth inhibito- ry effect of stevioside on ovarian cancer through AKT/ERK pathway. Biomed Res 28: 1820-1827.
Potocnjak I, Broznic D, Kindl M, Kropek M, Vladimir Knezevic S, et al. (2017) Stevia and stevioside protect against cisplatin nephrotoxici ty through inhibition of ERK1/2, STAT3, and NF-kB activation. Food Chem Toxicol 107: 215- 225.36. Hagh-Nazari L, Goodarzi N, Zangeneh MM, Zangeneh A, Tahvilian R, et al. (2017) Stereological study of kidney in streptozotocin induced di- abetic mice treated with ethanolic extract of Stevia rebaudiana (bitter fraction). Comp Clinic Pathol 26: 455-463.
Wang Y, Li L, Wang Y, Zhu X, Jiang M, Song E, Song Y (2018) New appli- cation of the commercial sweetener rebaudioside as a hepatoprotec- tive candidate: induction of the Nrf2 signaling pathway. Europ J Phar- macol 8: 128-137.
Latha S, Chaudhary S, Ray RS (2017) Hydroalcoholic extract of stevia rebaudiana bertoni leaves and stevioside ameliorates lipopolysaccha- ride-induced acute liver injury in rats. Biomed Pharmaco 95: 1040- 1050..
Arya A, Kumar S, Kasana MS (2012) In vitro regeneration of stevia and evaluation of antimicrobial and antiprotozoal properties of regenerat- ed calli and plants. Elect J Plant Breed 3: 916-924.