A Meta Analysis–Tridoshaj Sarvasara Mukhapaka Vis-À-Vis Oral Submucous Fibrosis
DOI:
https://doi.org/10.48165/Keywords:
Surgery, Tridoshaj Mukhapaka, Prevention, OralAbstract
Oral Submucous Fibrosis (OSMF) is a chronic disease characterized by the deposition of the abnormal collagen. It is a pre-malignant condition in approximately 2% of the cases. Ayurveda mentions a few matching conditions as Tridoshaj Sarvasara Mukhapaka & suggests various treatment modalities; local therapies as Gandusha & systemic ones as consumption of Rasayana, Tridoshaghna herbs & herbals, along with Nidana Parivarjana / Abstinence from addictions. This article reviews various aspects as literary & clinical studies pertaining to OSMF / Tridoshaj Sarvasara Mukhapaka as per the modern medicine, including prevention, Surgery, diet, lifestyle, physiotherapy, Ayurveda with other Complementary Alternative Medicines are reviewed here.
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Chole R.H., Gondivkar S.M., Gadbail A.R., Balsaraf S., Chaudhary S., Dhore S.V., Ghonmode S., Balwani S., Mankar M., Tiwari M., et al. Review of drug treatment of oral submucous fibrosis. Oral Oncol. 2012;48:393–398. doi: 10.1016/j.oraloncology.2011.11.021
Wang Y.Y., Tail Y.H., Wang W.C., Chen C.Y., Kao Y.H., Chen Y.K., Chen C.H. Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders. BMC Oral Health. 2014;14:99. doi: 10.1186/1472-6831-14-99
Tilakaratne W.M., Klinikowski M.F., Saku T., Peters T.J., Warnakula suriya S. Oral submucous fibrosis: Review on aetiology and pathogenesis. Oral Oncol. 2006;42:561– 568. doi: 10.1016/j.oraloncology.2005.08.005.
Zhang X., Reichart P.A. A review of betel quid chewing,
oral cancer and precancer in Mainland China Oral Oncol. 2007;43:424–
doi: 10.1016/j.oraloncology.2006.08.010. 6 .Paradakara PH, editor, Ashtanga Hridaya of Vagbhat, Uttartantra, 21 / 9, 6th Edition {Reprint},Varanasi:
Chaukhamba Surbharti Prakashna; 2010, p. 850 7. Pindborg JJ. Lesions of the oral mucosa to be considered premalignant and their epidemiology. In: Mackenzie IC, Dabelsteen E, Squier CA, editors. Oral Premalignancy. Iowa City: University of Iowa Press; 1980. p. 2-12. 8. Chang M.C., Lin L.D., Wu H.L., Ho Y.S., Hsien H.C., Wang T.M., Jeng P.Y., Cheng R.H., Hahn L.J., Jeng J.H. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: A potential role in oral submucous fibrosis—A precancer condition. Carcinogenesis. 2013;34:1096–1104. doi: 10.1093/carcin/bgt012.
Prabhu R.V., Prabhu V., Chatra L., Shenai P., Suvarna N., Dandekeri S. Areca nut and its role in oral submucous fibrosis. J. Clin. Exp. Dent. 2014;6:e569–e575. doi: 10.4317/jced.51318.
Arakeri G., Rai K.K., Hunasgi S., Merkx M.A.W., Gao S., Brennan P.A. Oral submucous fibrosis: An update on current theories of pathogenesis. J. Oral Pathol. Med. 2017;46:406–412. doi: 10.1111/jop.12581.
Aishwarya K.M., Reddy M.P., Kulkarni S., Doshi D., Reddy B.S., Satyanarayana D. Effect of frequency and duration of tobacco use on oral mucosal lesions—A cross sectional study among tobacco users in hyderabad,
India. Asian Pac. J. Cancer Prev. 2017;18:2233–2238 12. Liu B., Shen M., Xiong J., Yuan Y., Wu X., Gao X., Xu J., Guo F., Jian X. Synergistic effects of betel quid chewing, tobacco use (in the form of cigarette smoking), and alcohol consumption on the risk of malignant transformation of oral submucous fibrosis (OSF): A case control study in Hunan Province, China. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2015;120:337–345. doi: 10.1016/j.oooo.2015.04.013.
Lee C.H., Ko Y.C., Huang H.L., Chao Y.Y., Tsai C.C., Shieh T.Y., Lin L.M. The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan. Br. J. Cancer. 2003;88:366–372. doi: 10.1038/sj.bjc.6600727.
Nigam N.K., Aravinda K., Dhillon M., Gupta S., Reddy S., Srinivas Raju M. Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in moradabad district. J. Oral Biol. Craniofac. Res. 2014;4:8–13. doi: 10.1016/j.jobcr.2013.10.005
Gottipamula S., Sundarrajan S., Moorthy A., Padmanabhan S., Sridhar K.N. Buccal mucosal epithelial cells downregulate CTGF expression in buccalsubmucosal fibrosis fibroblasts. J. Maxillofac. Oral Surg. 2018;17:254–259. doi: 10.1007/s12663-017-1056-1
Cox S.C., Walker D.M. Oral submucous fibrosis. A review. Aust. Dent. J. 1996;41:294–299. doi: 10.1111/j.1834-7819.1996.tb03136
Tang J.G., Jian X.F., Gao M.L., Ling T.Y., Zhang K.H. Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. Community Dent. Oral Epidemiol. 1997;25:177–180. doi: 10.1111/j.1600- 0528.1997.tb00918
Gupta PC, Sinor PN, Bhonsle RB, Pawar VS, Mehta HC. Oral submucous fibrosis in India: a new epidemic? Natl Med J India. 1998;11(3):113–116. 19. Balakrishnan C., Aswath N. Estimation of serum, salivary immunoglobulin G, immunoglobulin A levels and total protein, hemoglobin in smokeless tobacco chewers and oral submucous fibrosis patients. Contemp. Clin. Dent. 2015;6:S157–S162.
Arakeri G., Rai K.K., Hunasgi S., Merkx M.A.W., Gao S., Brennan P.A. Oral submucous fibrosis: An update on current theories of pathogenesis. J. Oral Pathol. Med. 2017;46:406–412. doi: 10.1111/jop.12581
Guruprasad R., Nair P.P., Singh M., Singh M., Singh M., Jain A. Serum vitamin c and iron levels in oral submucous fibrosis. Indian J. Dent. 2014;5:81–85. doi: 10.4103/0975-962X.135266
Wang Y.P., Wu Y.C., Cheng S.J., Chen H.M., Sun A., Chang J.Y. High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. J. Formos. Med. Assoc. 2015;114:813–819.
doi: 10.1016/j.jfma.2015.05.011
Teh M.T., Tilakaratne W.M., Chaplin T., Young B.D., Ariyawardana A., Pitiyage G., Lalli A., Stewart J.E., Hagi Pavli E., Cruchley A., et al. Fingerprinting genomic instability in oral submucous fibrosis. J. Oral Pathol. Med. 2008;37:430–436.doi: 10.1111/j.1600
00643
Itagi AB, Arora D, Patil NA, Bailwad SA, Yunus GY, Goel A. Short-term acute effects of gutkha chewing on heart rate variability among young adults: A cross sectional study. Int J Appl Basic Med Res 2016; 6(1): 45- 9.
Dinshaw KA, Shastri SS, Patil SS. Cancer control
programmein India: challenges for the new millennium. Health Adm 2005; 18(1): 10-3
Shevale VV, Kalra RD, Shevale VV, Shringarpure MD. Management of oral sub-mucous fibrosis: a review. Ind J Dent Sci 2012; 2(4): 107-14.
Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases 28. Kerr AR, Warnakulasuriya S, Mighell AJ, et al. A systematic review of medical interventions for oral submucous fibrosis and future research opportunities. Oral Dis 2011; 17(Suppl. 1): 42-57.
Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases 29. Kerr AR, Warnakulasuriya S, Mighell AJ, et al. A systematic review of medical interventions for oral submucous fibrosis and future research opportunities. Oral Dis 2011; 17(Suppl. 1): 42-57.
Acharya YT, editor, Sushruta samhita, Nidansthan,16 / 65- 66, 3rd edition , Varanasi: Chaukhamba Subharati Prakashna; 2010 p.605
https://www.sciencedirect.com/science/article/abs/pii/ S2212426820301196
https://www.sciencedirect.com/science/article/abs/pii/0 278239191900024
https://www.sciencedirect.com/science/article/abs/pii/ S0901502705804734
https://link.springer.com/article/10.1007/BF02872409 35.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46872 36/
https://www.researchgate.net/profile/PrathameshFulsu ndar/publication/336890192_A_Review_of_Various_Alli ed_Therapies_for_Treatment_of_Oral_Submucous_Fibro sis/links/5db91bdd4585151435d1abe5/A-Review-of
Various-Allied-Therapies-for-Treatment-of-Oral Submucous-Fibrosis.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43959 29/
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600 -0714.2012.01168.x
https://www.sciencedirect.com/science/article/abs/pii/ S1368837511009110