Relation Between Gut Brain Axis and Agni

Aarti Chande; Acharya G Shripathi; Sreelakshmy Changath

doi:10.48165/

Authors

Aarti Chande Post Graduate Scholar, Department of Kayachikitsa, Muniyal Institute of Ayurveda Medical Sciences, Manipal Author
Acharya G Shripathi Director Academic and WHO collaborator, HOD, Department of Kayachikitsa, Muniyal Institute of Ayurveda Medical Sciences, Manipal Author
Sreelakshmy Changath Assistant Professor, Department of Kayachikitsa, KTG Ayurvedic Medical College and Hospital, Banglore Author

DOI:

https://doi.org/10.48165/

Keywords:

Gut-brain axis, Agni, Ayurveda, Gut microflora

Abstract

"All diseases begin in the gut" - Hippocrates of Kos, this statement was made by Greek physician Hippocrates, regarded as the father of modern medicine1; although the importance of Agni (the digestive fire) has already been sold by Acharya charaka when he states that "the cause of all diseases is Mandagni" It has become evident that the intestinal bacteria and flora can affect the central nervous system (CNS) physiology and has an important role to play in the pathological conditions of the same. The nervous system and the gastrointestinal tract are communicating through a bidirectional network of signaling pathways called the gut-brain axis, which consists of multiple connections, including the vagus nerve, the immune system, and bacterial metabolites and products. It is clearly visible in the case of psychosomatic disorders like Ulcerative colitis, etc. that Gut is affected by Brain and vice-versa.

Downloads

Download data is not yet available.

References

Lynch SV, Pedersen O.. The human intestinal microbiome in health and disease. N Engl J Med 2016;375:2369–79. 2. Sudo, N; Chida, Y; Aiba, Y (2004). "Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal

system for stress response in mice". J Physiol. 558 (1): 263–275.

Divya K., Tripathi J.S., Tiwari S.K. Exploring Novel concept of agni and its clinical relevance. Altern Integr Med. 2013;02(08)

Tiwari M. Lotus Press; Twin Lakes, WI: 1995. Ayurveda secrets of healing: the complete Ayurvedic guide to healing through Pancha Karma seasonal therapies, diet, herbal remedies, and memory.

Wang, Y; Kasper, LH (May 2014). "The role of microbiome in central nervous system disorders". Brain Behav Immun. 38: 1– 12. doi:10.1016/j.bbi.2013.12.015. PMC 4062078. PMID 24370461

Rutsch A, Kantsjö JB and Ronchi F (2020) The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Front. Immunol. 11:604179. doi: 10.3389/fimmu.2020.604179

Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014;146:1500-1512.

Azzam I, Gilad S, Limor R, Stern N, Greenman Y. Ghrelin stimulation by hypothalamic-pituitary-adrenal axis activation depends on increasing cortisol levels. Endocr Connect. 2017;6(8):847-855.

Dupont HL. Review article: Evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets. Aliment Pharmacol Ther. 2014;39:1033-1042.

Shastry S; Madhavanidana with madhukosha Sanskrit commentary by Sri Vijayarakshita and srikantadatta, Varanasi Sanskrit; ed 2006, Chapter 6/7-8, pp183.

Tripathi B, Charak samhita, Maharshi charak, vimanshthan, chapter 5, verse no. 21, Chaukhamba surubhi Prakashan, Varanasi, 2011

Acharya YT, Charak Samhita of Agnivesa, with Ayurvedadipika commentary by sri Chakrapanidatta Sloka [Ch.Su.28/9-10]; Varanasi; Chaukhamba Surbharati Prakashan; 2013.pp.179.

Acharya YT, Charak Samhita of Agnivesa, with Ayurvedadipika commentary by sri Chakrapanidatta Chikitsa Sthana,Ch-9,Sloka-5.Varanasi, Choukambha Krishnadas Academy, Varanasi, reprint-2015,pp: 738