Effects of Quercetin on Aspirin-Induced Haemato-Biochemical Alterations in Wistar Rats
DOI:
https://doi.org/10.48165/ijvsbt.19.5.08Keywords:
Aspirin, Haemato-biochemical alterations, Quercetin, Wistar ratsAbstract
Aspirin is a non-steroidal anti-inflammatory drug (NSAID). Quercetin is natural flavonoid present in high concentration in herbal drugs, fruits and vegetables and demonstrating broad bio-pharmacological properties. This study was aimed to evaluate the ameliorative effects of quercetin (@ 100 & 200 mg/kg b.wt.) in aspirin (@ 100 mg/kg b.wt.) induced haemato- biochemical alterations in Wistar rats (n=36) over a period of 28 days. There was significant decrease in mean values of haemoglobin, packed cell volume, platelets and increase in total leucocyte count in aspirin treated rats (Gr. II) over the control group (Gr I) at 28th day of experiment. Similarly, in biochemical parameters also there was significant elevation in aspartate aminotransferase, alanine aminotransferase, urea and creatinine and significant decrease inmean values of total protein, albumin, triglyceride and cholesterol in aspirin treated rats. Administration of quercetin at higher dose rate of 200 mg/kg b.wt. for 28 days (Gr. III) along with the aspirin in Wistar rats prevented such alterations in different haemato-biochemical parameters as the values on day 28 were almost similar to those on day 0 and at par with control group. Hence, quercetin @ 200 mg/kg b.wt. along with aspirin @ 100 mg/kg b.wt. can be recommended to avoid aspirin induced health issues in high risk mammals.
Downloads
References
Asmaa, S.M., Al-Diwan, M.A., & AL-Jadaan, S.A. (2018). Hematological profile of rats treated with Quercetin derivative against carbon tetrachloride (CCL4) toxicity. Basrah Journal of Veterinary Research, 17(2), 70-84.
Das, S.K., & Roy, C. (2012). The protective role of aeglemarmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: a possible involvement of antioxidants. Saudi Journal of Gastroenterology, 18(3), 188.
David, S., & Hamilton, J.P. (2010). Drug-induced liver injury. US Gastroenterology and Hepatology Review, 6, 73.
El-Ashmawy, I.M., Ebeid, M.A., Aljohani, M.S., Alhumaydhi, F.A., & Aljohani, A.S. (2022). Assessment of the hepatorenal and hematological parameters of rats exposed to graded doses of lysine acetylsalicylate. Journal of Taibah University for Science, 16(1), 214-223.
El-Sheikh, S.M., Bahaa, H.M., Galal, A. A., Metwally, M.M., Said, M.A., Alattar, R.H., & Fahmy, E.M. (2022). Gastroprotective, hepatoprotective, and nephroprotective effects of thymol against the adverse effects of acetylsalicylic acid in rats: Biochemical and histopathological studies. Saudi Journal of Biological Sciences, 29(6), 103289.
Elyazji, N.R., Abdel-Aziz, I., & Ashour, A.A. (2015). Some hematological and biochemical changes associated with aspirin administration in albino rats. Al-Aqsa University Journal (Natural Sciences Series), 19(1), 63-76.
Jain, N., Raghuwanshi, A.K., &Shrivastava, V.K. (2011). The effect of acetylsalicylic acid on hematological and biochemical parameters in female albino rats. International Journal of Applied Biology and Pharmaceutical Technology, 2(3), 412-418.
Jain, N., Shrivastava, R.., Raghuwanshi, A., & Shrivastava, V. (2012). Aspirin induced changes in serum ACP, ALP, GOT, GPT, bilirubin and creatinine in correlation with histopathological changes in liver and kidney of female albino rat. International Journal of Applied Pharmaceutics, 4, 9-11.
Kasmi, S., Bkhairia, I., Harrabi, B., Mnif, H., Marrakchi, R., Ghozzi, H., Kallel, C., Nasri, M., Zeghal, K., Jamoussi, K., & Hakim, A. (2018). Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. Toxicology Mechanisms and Methods, 28(1), 12-22.
Merchant, M.A., & Modi, D.N. (2004). Acute and chronic effects of aspirin on hematological parameters and hepatic ferritin expression in mice. Indian Journal of Pharmacology, 36(4), 226.
Miescher, P.A. (1986). Blood dyscrasias secondary to non-steroidal anti-inflammatory drugs. Medical Toxicology, 1, 57-70.
Moridani, M.Y., Pourahmad, J., Bui, H., Siraki, A., & O’Brien, P.J. (2003). Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radical Biology and Medicine, 34(2), 243-253.
Plotz, P.H., & Kimberly, R.P. (1981). Acute effects of aspirin and acetaminophen on renal function. Archives of Internal Medicine, 141(3), 343-348.
Rafeeq, A., Najam, R., & Hussain, S.J. (2016). Aspirin associated liver toxicity–The optimal dose of aspirin in liver insufficiency. International Journal of Scientific Research in Knowledge, 4, 28-32.
Rainsford, K.D. (2013). Aspirin and the Salicylates. Elsevier.
Renugadevi, J., & Prabu, S.M. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology, 62(5), 471-481.
Ross, J.A., & Kasum, C.M. (2002). Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual Review of Nutrition, 22(1), 19-34.
Tomoda, T., Kurashige, T., Hayashi, Y., & Enzan, H. (1998). Primary changes in liver damage by aspirin in rats. Pediatrics International, 40(6), 593-596.
Vane, J.R., & Botting, R.M. (1998). Anti-inflammatory drugs and their mechanism of action. Inflammation Research, 47, 78-87.
Vyas, A., Ram, H., Purohit, A., & Jatwa, R. (2016). Adverse effects of subchronic dose of aspirin on reproductive profile of male rats. Journal of Pharmaceutics, 2016, 1-5.
Yousef, M. I., Omar, S. A., El-Guendi, M. I., & Abdelmegid, L. A. (2010). Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food and Chemical Toxicology, 48(11), 3246-3261.
Published
Issue
Section
License
Copyright (c) 2023 Indian Journal of Veterinary Sciences & Biotechnology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
