Effects of Xylazine and Dexmedetomidine as a Preanaesthetic Agent with Tiletamine-Zolazepam Anaesthesia on Clinico -Haemato-Biochemical Profile in Dogs
DOI:
https://doi.org/10.48165/ijvsbt.22.3.28Keywords:
Clinico-physiological parameters, Dexmedetomidine, Dogs, Haemato-biochemical parameters, T-Z Anaesthesia, Xylazine.Abstract
The present clinical study assessed the clinico-physiological and haemato-biochemical effects of xylazine and dexmedetomidine as preanaesthetic agents in dogs anaesthetised with tiletamine-zolazepam. A total of 12 dogs were presented for major surgical procedures. They were randomly divided into two groups: Group I received xylazine (@ 1 mg/kg BW, IM) and Group II received dexmedetomidine (@ 0.01 mg/kg BW, IM), followed by intravenous induction with tiletamine-zolazepam (@ 3 mg/kg BW till effect) and maintenance with the same @ one-half of induction dose. Clinico-physiological and haemato-biochemical parameters were recorded before, during and at 15 minutes intervals post-induction. Both anaesthetic protocols maintained cardiovascular and respiratory stability, time-dependent variations observed within groups. No significant differences were noted between groups, indicating well-preserved cardiac function and overall cardiovascular health. Haemato-biochemical parameters showed fluctuations but remained within normal physiological limits confirming adequate hepatic and renal safety.
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Chandramohan, S., Sooryadas, S., Dinesh, P. T., Jineshkumar, N. S., Remya, V., Anoop, S., & David, P. V. (2026). Multimodal balanced general anaesthesia using tiletamine-zolazepam, butorphanol, dexmedetomidine, propofol, ketamine and lignocaine in dogs. Indian Journal of Veterinary Surgery, 45(1), 21–26.
Grubb, T., & Lobprise, H. (2020). Local and regional anaesthesia in dogs and cats: Overview of concepts and drugs (Part 1). Veterinary Medicine and Science, 6(2), 209–217.
Koli, P. H., Parikh, P. V., Mahla, J. K., & Barot, H. M. (2021). Clinical attributes of tiletamine-zolazepam induced anesthesia with and without xylazine premedication in dogs. Indian Journal of Veterinary Sciences and Biotechnology, 17(4), 61–65.
Kusolphat, P., Soimala, T., & Sunghan, J. (2022). Intraocular pressure and cardiovascular effects of dexmedetomidine premedication and tiletamine-zolazepam for anesthetic induction in dogs. Veterinary World, 15(12), 2929–2936.
Kwon, Y. S., Jeong, J. H., & Jang, K. H. (2003). Comparison of tiletamine/zolazepam, xylazine-tiletamine/zolazepam and medetomidine-tiletamine/zolazepam anaesthesia in dogs. Journal of Veterinary Clinics, 20(1), 33–41.
Lu, D. Z., Jiang, S., Yu, S. M., & Fan, H. G. (2014). A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam/xylazine and tiletamine-zolazepam/xylazine/tramadol in dogs. Pakistan Veterinary Journal, 34(1), 63–67.
McIver, K. A., Boveland, S. D., Clark-Price, S. C., & Hofmeister, E. H. (2023). Effects of tiletamine-zolazepam vs. propofol on peri-induction intraocular pressure in dogs: A randomized, masked crossover study. Frontiers in Veterinary Science, 10, 1–16.
Mujiburraheman, B. Z. (2021). Comparative evaluation of ketamine-diazepam and tiletamine-zolazepam as induction agent with maintenance on isoflurane anaesthesia in dogs (M.V.Sc. Thesis). Kamdhenu University, Gujarat, India.
Murrell, J. C., & Hellebrekers, L. J. (2005). Recent developments in the clinical assessment and management of pain in dogs and cats. Veterinary Anaesthesia and Analgesia, 32(4), 183–201.
Mwangi, W. E., Mogoa, E. M., & Mbuthia, P. G. (2014). Clinical and cardiopulmonary effects of tiletamine-zolazepam anaesthesia in dogs. Kenya Veterinarian, 38(1), 32–38.
Raffe, M. R., & Knottenbelt, D. C. (2016). Total intravenous anaesthesia. In T. Duke-Novakovski, M. de Vries, & C. Seymour (Eds.), BSAVA manual of canine and feline anaesthesia and analgesia (3rd ed., pp. 145–158). BSAVA, Gloucester, England.
Saini, R., Jadon, N. S., Kandpal, M., & Kumar, A. (2019). Clinicophysiological and haemato-biochemical effects of dexmedetomidine as preanesthetic in combination with thiopental sodium and ketamine in dogs. The Pharma Innovation Journal, 8(7), 12–17.
Sharma, R., Kumar, A., Kumar, A., Sharma, S. K., Sharma, A., & Tewari, N. (2014). Comparison of xylazine and dexmedetomidine as a premedicant for general anaesthesia in dogs. Indian Journal of Animal Sciences, 84(1), 8–12.
Snedecor, G. W., & Cochran, W. G. (1994). Statistical methods (9th ed.). Iowa State University Press, Ames, Iowa, USA.
Sutil, D. V., Mattoso, C. R., Volpato, J., Weinert, N. C., Costa, Á., Antunes, R. R., & Saito, M. E. (2017). Haematological and splenic doppler ultrasonographic changes in dogs sedated with acepromazine or xylazine. Veterinary Anaesthesia and Analgesia, 44(4), 746–754.
Tiwari, K., Jadon, N. S., Pandey, P., Kandpal, M., & Bhatt, J. (2024). Evaluation of clinicophysiological and haematobiochemical parameters in propofol-sevoflurane anaesthesia alone and in combination with dexmedetomidine and butorphanol in atropinized dogs. Veterinary Practitioner, 25(2), 170–176.
Tranquilli, W. J., & Grimm, K. A. (2015). Introduction chapter. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), Lumb and Jones’ veterinary anesthesia and analgesia (5th ed., pp. 3–10). John Wiley & Sons, Hoboken, New Jersey.
Zalavadiya, S. H., Vadalia, J. V., Vagh, A. A., Bhatt, R. H., Talekar, S. H., Dodia, V. D., & Bhesaniya, M. B. (2024). Comparative anaesthetic effects of propofol and tiletamine-zolazepam anaesthetic agents in dogs. Indian Journal of Veterinary Sciences and Biotechnology, 20(3), 153–157.
Zhang, Z., Du, X., Bai, H., Shen, M., Ma, X., Li, R., Jin, X., & Gao, L. (2021). Cardiopulmonary (no ventilation) and anesthetic effects of dexmedetomidine-tiletamine in dogs. Frontiers in Veterinary Science, 8, 1–9.
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