Therapeutic Efficacy of Intermittent Haemodialysis in Dogs with Progressive Renal Impairment
DOI:
https://doi.org/10.48165/ijvsbt.22.3.19Keywords:
Dog, Intermittent haemodialysis, Renal Failures.Abstract
Renal failure is a common and clinically significant condition in dogs, necessitating thorough diagnostic evaluation and timely therapeutic intervention. This study evaluated 50 dogs exhibiting clinical signs of renal dysfunction and serum creatinine concentrations exceeding 1.4 mg/dL. All dogs underwent comprehensive clinical examination, haematological and serum biochemical analysis, and routine urinalysis to determine the severity and nature of renal impairment. Anaemia, azotemia characterized by elevated BUN and creatinine concentrations, hyperphosphatemia, and related abnormalities were among the most common significant findings. Based on clinical status and treatment requirements, 7 of the 50 dogs received intermittent haemodialysis (IHD) in addition to standard medical therapy. Dogs receiving IHD showed marked clinical improvement, especially with respect to uremia-associated signs compared to conventional therapy, and resulted in significant reductions in BUN, creatinine, and inorganic phosphorus concentrations, as reflected by meaningful urea and creatinine reduction ratios after each dialysis session. Electrolyte concentrations and liver-associated biochemical parameters remained largely stable, suggesting that IHD, when appropriately prescribed and monitored, is a safe therapeutic intervention without inducing major biochemical derangements. Despite the evident biochemical and clinical benefits, survival outcomes remained guarded in dogs with stage IV chronic renal failure. However, dogs in earlier stages of renal disease, demonstrated prolonged survival, underscoring the importance of early diagnosis and timely initiation of advanced renal replacement therapies. The study provides an in-depth diagnostic characterization of canine renal insufficiency and offers comparative insight into the therapeutic outcomes of conventional management versus adjunctive haemodialysis.
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