Outbreak of Salmonellosis in a Laboratory Swiss Albino Mice Colony
DOI:
https://doi.org/10.48165/ijvsbt.22.3.09Keywords:
Mice, Outbreak, Salmonella TyphimuriumAbstract
A colony of Swiss albino mice was presented with signs of dullness, anorexia with ruffled coat, hunched posture, varying degrees of conjunctivitis and diarrhea. Mice tissues, fecaes, feed, water and bedding material samples were collected for bacteriological examination. Necropsy examination of the mice revealed hepatospleenomegaly, white foci in liver, congestion in kidney and intestines filled with mucoid exudates. The most common histopathological finding was hepatic and splenic necrosis. The bacterial analysis of mice tissues and fecal samples revealed pure culture of Salmonella Typhimurium and serotyping confirmed Salmonella enterica serotype Typhimurium 4, 12:i:1, 2. The antibiotic sensitivity test revealed that the isolate was highly sensitive to amoxyclav and fluroquinolones and was resistant to aminoglycoside. The mice colony was not treated with antibiotics but was euthanized. From our experience of disease outbreak we inferred that routine screening of animals and gross necropsy findings are very helpful in early diagnosis of disease.Downloads
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