Early Identification of Renal Disease in Dogs with Suspected Renal Insult using Haemato-Biochemical, Urinary, and Advanced Biomarker Profiling
DOI:
https://doi.org/10.48165/ijvsbt.22.2.24Keywords:
Dogs, Renal insufficiency, Early renal biomarkers, Proteinuria, SDMA,Abstract
Renal disease represents a common and clinically important disorder in dogs, often associated with significant morbidity and mortality. Early renal insult frequently remains undetected when diagnosis relies solely on conventional markers such as serum creatinine, which may not increase until substantial nephron loss has occurred. Consequently, early identification of renal dysfunction is essential to enable timely therapeutic intervention, slow disease progression, and improve clinical outcomes. The present study was undertaken to assess the diagnostic value of an integrated approach combining haemato-biochemical parameters, urinary indices, and advanced renal biomarker profiling for the early identification and characterization of renal disease in dogs with suspected renal insult. Twenty five middle-aged to geriatric dogs presenting with clinical conditions known to predispose renal injury were enrolled. Dogs suffering from gastrointestinal, urinary, hepatic and miscellaneous systemic disorders demonstrated varying degrees of renal involvement during the monitoring period. Clinical examination, haemato-biochemical profiling, urinalysis, urine protein to creatinine ratio (UPC), urine microalbumin and serum symmetric dimethylarginine (SDMA) were evaluated on day 1 and subsequently monitored on days 45 and 90. A mild elevation in urine microalbumin and symmetric dimethylarginine (SDMA) concentrations was detected in a subset of dogs upon successive evaluation on days 45 and 90. The findings demonstrated that combined assessment of haemato-biochemical parameters, urinary indices, and advanced biomarkers provides a sensitive and comprehensive approach for early identification of renal disease in dogs with suspected renal insult. Incorporation of advanced biomarker profiling alongside conventional diagnostics can facilitate earlier diagnosis, guide clinical decision-making, and potentially improve renal outcomes in canine patients.Downloads
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