Haemato-Biochemical Alterations in Cattle Naturally Infected with Lumpy Skin Disease
DOI:
https://doi.org/10.48165/ijvsbt.22.1.31Keywords:
Cattle, Diagnosis, Haematology, Lumpy skin disease, Serum biochemistryAbstract
Lumpy skin disease (LSD) is an emerging viral disease of cattle, causing substantial economic losses due to decreased productivity and increased morbidity. This study investigated haematological and biochemical alterations in LSD-affected cattle (n=150) compared to healthy controls (Group A, n=25). LSD-infected animals were categorised according to the severity of infection based on clinical signs in to Group B: Mild LSD infection (n=42), Group C: Moderate LSD infection (n=84), and Group D: Severe LSD infection (n=24). Infected animals exhibited significant leukopenia, lymphopenia, neutrophilia, macrocytic hypochromic anaemia, and thrombocytopenia in accordance with the severity of the disease. Biochemical analysis showed reduced total protein and albumin with elevated blood urea nitrogen, creatinine, ALT, and AST, particularly in severe cases, and these alterations were also in accordance with the severity of the disease. The values of almost all haemato-biochemical parameters were significantly (p<0.01) altered from those of healthy controls. These findings highlight the utility of blood and serum biochemical profiling as valuable diagnostic and prognostic tools for timely disease detection and effective management in endemic regions.
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Adamu, K., Abayneh, T., Getachew, B., Mohammed, H., Deresse, G., Zekarias, M., … Gelaye, E. (2024). Lumpy skin disease virus isolation, experimental infection, and evaluation of disease development in a calf. Scientific Reports, 14(1), 20460.
Ahmed, A. M., & Dessouki, A. A. (2013). Clinical, haematologic, and biochemical studies on cattle naturally infected with lumpy skin disease. Veterinary World, 6(6), 279–282.
Amenu, A., Bekuma, F., Abafaji, G., & Abera, D. (2018). Review on epidemiological aspects and economic impact of lumpy skin disease. Journal of Dairy and Veterinary Science, 7(4), 555–716.
Babiuk, S., Bowden, T. R., Boyle, D. B., Wallace, D. B., & Kitching, R. P. (2008). Capripoxviruses: An emerging worldwide threat to sheep, goats, and cattle. Transboundary and Emerging Diseases, 55(7), 263–272.
Bowden, T. R., Coupar, B. E., Babiuk, S. L., White, J. R., Boyd, V., Duch, C. J., & Boyle, D. B. (2009). Detection of antibodies specific for sheep pox and goat pox viruses using recombinant capripoxvirus antigens in an indirect enzyme-linked immunosorbent assay. Journal of Virological Methods, 161(1), 19–29.
Carn, V. M., Kitching, R. P., Hammond, J. M., & Chand, P. (1994). Use of a recombinant antigen in an indirect ELISA for detecting bovine antibody to capripoxvirus. Journal of Virological Methods, 49(3), 285–294.
El-Hamed, A. H. A., & Ali, M. M. (2017). Clinical, haematological and biochemical findings in cattle naturally infected with lumpy skin disease. Alexandria Journal of Veterinary Sciences, 54(1), 173–181.
Feyisa, A. F. (2018). A case report on clinical management of lumpy skin disease in a bull. Journal of Veterinary Science & Technology, 9(3), 538.
Keshta, H. G., Allam, A. M., Fadl, S. E., & El Beskawy, M. (2020). Detection of lumpy skin disease during an outbreak in summer 2019 in Menoufia Governorate, Egypt using clinical, biochemical and molecular diagnosis. Zagazig Veterinary Journal, 48(4), 378–389.
Liang, Z., Lin, S., Deng, Q., et al. (2022). Research advances on lumpy skin disease: Epidemiology, pathogenesis, and novel diagnosis and control strategies. Viruses, 14(5), 1085.
Manjunathareddy, G. B., Rathinam, T., Elangovan, R., et al. (2024). Pathological, immunological and molecular study on lumpy skin disease outbreak in cattle. Veterinary Research Communications, 48(1), 173–184.
Neamat-Allah, A. N. (2015). Immunological, haematological, biochemical, and histopathological studies on cows naturally infected with lumpy skin disease. Veterinary World, 8(9), 1131.
OIE. (2013). Lumpy skin disease: Technical disease card. World Organisation for Animal Health.
OIE. (2021). Lumpy skin disease. In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals (pp. 1–17). World Organisation for Animal Health.
Quinn, P. J., Markey, B. K., Leonard, F. C., FitzPatrick, E. S., & Fanning, S. (2016). Concise review of veterinary microbiology (2nd ed.). John Wiley & Sons.
Rouby, S. R., Shehata, O., Abdel-Moneim, A. S., Hussein, K. H., & Mahmoud, M. M. (2021). Lumpy skin disease in calves: The association between clinical signs and biochemical alterations. Advances in Animal and Veterinary Sciences, 9(11), 1863–1868.
Şevik, M., Avci, O., Doğan, M., & İnce, Ö. B. (2016). Serum biochemistry of lumpy skin disease virus-infected cattle. BioMed Research International, 2016, 1–6.
Sudhakar, S. B., Mishra, N., Kalaiyarasu, S., Jhade, S. K., Hemadri, D., Sood, R., & Singh, V. P. (2020). Lumpy skin disease outbreaks in cattle in Odisha state, India in August 2019: Epidemiological features and molecular studies. Transboundary and Emerging Diseases, 67(6), 2408–2422.
Tuppurainen, E. S. M., & Oura, C. A. L. (2012). Lumpy skin disease: An emerging threat to Europe, the Middle East, and Asia. Transboundary and Emerging Diseases, 59(1), 40–48.
Tuppurainen, E. S., Stoltsz, W. H., Troskie, M., Wallace, D. B., Oura, C. A. L., Mellor, P. S., & Venter, E. H. (2011). A potential role for ixodid (hard) tick vectors in the transmission of lumpy skin disease virus in cattle. Transboundary and Emerging Diseases, 58(2), 93–104.
Tuppurainen, E., Alexandrov, T., & Beltrán-Alcrudo, D. (2017). Lumpy skin disease: A manual for veterinarians. FAO Animal Production and Health Manual No. 20.
Yadav, P., Kumar, A., Nath, S. S., Devasurmutt, Y., Shashidhar, G., Joshi, M., & Tatu, U. (2024). Unravelling the genomic origins of lumpy skin disease virus in recent outbreaks. BMC Genomics, 25(1), 196.
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