Acetamiprid Induced General and Reproductive Toxicity in Male Wistar Rats
DOI:
https://doi.org/10.48165/ijvsbt.22.2.05Keywords:
Acetamiprid, Induced toxicity, Macro-microscopic alterations, Sperm parameters, Testes, Wistar ratAbstract
Acetamiprid, a novel insecticide of neonicotinoid class, is used widely in agricultural practice for its significant insecticidal potential. Human and animal are directly or indirectly exposed to acetamiprid. The present study was planned to investigate the toxic potential of acetamiprid on male reproductive system of Wistar rats. Total 40 healthy male Wistar rats aged 6 to 8 weeks were randomly and equally divided in four groups (n=10) based on body weight. Group I served as control, while groups II, III and IV were dosed daily orally with acetamiprid @ 7.75, 15.5, and 31.0 mg/kg body weight, respectively, for 45 days. All the rats were examined daily for appearance of any abnormal clinical signs or mortality. Rats were weighed on weekly interval. There were no clinical signs or morality throughout the study. No significant alteration was found in haematological and serum biochemical analysis compared to control group, except slight increase in serum urea level in treatment group, yet statistically comparable with that of control group. The gross examination showed no detectable macroscopic lesions in any of the organs in any of the rats. There was no any deviation in sperm parameters as compared to control group. Microscopic examination of different organs revealed no any test article related abnormality, except few incidental changes with only minimal severity, such as vacuolation in hepatocytes and alveolar histiocytosis. In conclusion,oral acetamiprid did not produce adverse effect in male Wistar rats even at 31.0 mg/kg body weight.
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