Evaluation of Prognostic Biomarkers and Acute Phase Proteins to Predict Survivability in Acute Abdomen Dogs
DOI:
https://doi.org/10.48165/ijvsbt.22.2.32Keywords:
Acute abdomen dogs, Acute phase proteins, Biomarkers, Prognosis.Abstract
Acute abdomen is characterized by sudden onset of abdominal pain which develops due to multiple etiologies. It is a life-threatening emergency that requires rapid recognition of disease severity and early prognosis prediction for timely treatment. This study was aimed to assess the prognostic utility of acute phase proteins and biomarkers including lactate, C-reactive protein, procalcitonin, D-dimer and interleukin-6 in dogs presented with acute abdomen. In this study, 52 dogs presented to critical care unit of Madras Veterinary College Teaching Hospital, Chennai with the history of depression, abdominal pain, vomiting and distended abdomen were subjected to a standard diagnostic protocol. Comprehensive assessments including physical examination, vital sign monitoring, haematology, serum biochemistry, blood gas analysis and imaging studies were performed in all the dogs. Out of which 36 (69.23%) dogs were diagnosed with acute abdomen and acute phase protein analysis were performed in those dogs. Statistical analysis of biomarkers lactate, C-reactive protein, procalcitonin, D-dimer and IL-6 highlighted the significance of acute phase proteins and biomarkers in predicting outcome in dogs with acute abdomen.
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