Haemato-Biochemical Changes in Dogs Affected with Immune Mediated Haemolytic Anaemia Caused by Babesia gibsoni

Authors

  • Soundarya Thollapalli Chandrashekara Reddy Department of Veterinary Medicine, Veterinary College, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal-560024, Bengaluru, Karnataka, India
  • Anil Kumar Malige Chandrashekhariah Department of Veterinary Clinical Complex, Veterinary College, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal-560024, Bengaluru, Karnataka, India
  • Kshama Manepanda Appaiah Department of Veterinary Medicine, Veterinary College, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal-560024, Bengaluru, Karnataka, India
  • Shivaraj Murag Department of Veterinary Microbiology, Institute of Animal Health & Veterinary Biologicals, Hebbal-560024, Bengaluru, Karnataka, India
  • Keeramande Ramakrishna Anjan Kumar Department of Veterinary Pathology, Veterinary College, Karnataka Veterinary, Animal and Fisheries Sciences University, Hassan-573202, Karnataka, India
  • Pavithra Balekatte Hanumantha 5Department of Veterinary Pharmacology and Toxicology, Veterinary College, Karnataka Veterinary, Animal and Fisheries Sciences University, Gadag-582101, Karnataka, India

DOI:

https://doi.org/10.48165/ijvsbt.20.4.22

Keywords:

Babesia gibsoni,, Coombs test, Immune mediated haemolytic anaemia (IMHA), Saline agglutination test,, Spherocytosis.

Abstract

The present study was conducted in dogs (n=18) presented to small animal OPD, Department of Veterinary Medicine in Bangalore with  clinical signs of canine babesiosis. Eighteen dogs were primarily screened for Babesia gibsoni infection by blood smear examinations and  then confirmed by PCR. Further these dogs were subjected to saline agglutination test, spherocytosis in blood smear examination and  Coombs test for diagnosis of immune mediated haemolytic anaemia (IMHA). The variations in haematological and serum biochemical  analysis of dogs affected with IMHA caused by Babesia gibsoni were studied. Haematology revealed significant increase in TLC and a  significant decrease in mean TEC, Hb, PCV and platelet count. Biochemical analysis revealed significant increase in mean ALT, ALP, total  bilirubin, creatinine, BUN; significant decrease in mean albumin level and non-significant decrease in total protein with non-significant  elevation in globulin levels. 

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References

Anju, S., Vijayakumar, K., Sulficar, S., Shyma, V.H., & Deepa, P.M. (2022). Haemato-biochemical changes associated with Babesia gibsoni infection in dogs. Journal of Veterinary and Animal Sciences, 53(1), 22-26.

Ashwini, M., Usha Narayana Pillai, Ajithkumar, S., Tresamol, P.V., & Deepa Chirayath (2017). Haematological changes in dogs affected with immune mediated haemolyticanaemia. International Journal of Livestock Research, 7(8), 221-227.

Aysul, N., Ural, K., Ulutaş, B., Eren, H., & Karagenc, T. (2013). First detection and molecular identification of Babesia gibsoni in two dogs from the Aydın Province of Turkey. Turkish Journalof Veterinary & Animal Sciences, 37(2), 226-229.

Bilwal, A.K., Mandali G.C., & Tandel, F.B. (2017). Clinico-pathological alterations in naturally occurring Babesia gibsoni infection in dogs of Middle-South Gujarat, India. Veterinary World, 10(10), 1227-1232.

Brahma, J., Chandrasekaran, D., Jayathangaraj, M.G., Vairamuthu, S., & Soundararajan, C. (2019). Clinical, haemato-biochemical and molecular findings of babesiosis in dogs. International Journal of Current Microbiology Applied Sciences, 8(1), 2127-2132.

Halder, B., & Gupta, A.R. (2022). Haemato-biochemical alteration and therapeutic management of canine babesiosis. Indian Journal of Animal Health, 151(1-2), 289-296.

Inokuma, H., Yoshizaki, Y., Matsumoto, K., Okuda, M., Onishi, T., Nakagome, K., Kosugi, R., & Hirakawa, M. (2004). Molecular survey of babesia infection in dogs in Okinawa, Japan. Veterinary Parasitology, 121(3-4), 341-346.

Ishihara, M., Fujino, Y., Setoguchi, A., Takahashi, M., Nakashima, K., Ohno, K., & Tsujimoto, H. (2010). Evaluation of prognostic factors and establishment of a prognostic scoring system for canine primary immune-mediated haemolytic anaemia. Journal of Veterinary Medical Science, 72(4), 464-470.

Jadhav, R.K., Kumari, R.R., Jameel, J.A., & Kumar, P. (2011). Emergency of arthropod transmitted infections in kennel dogs. Veterinary World, 4, 522-528.

Jain, K.J., Lakshmanan, B., Syamala, K., Praveena, J.E., & Aravindakshan, T. (2017). High prevalence of small babesia species in canines of Kerala, South Indian Veterinary World, 10(11), 1319-1323.

Kumar, P., & Kumar, A. (2020). Therapeutic management and haemato-biochemical changes in Chennai city. Tamilnadu Journal of Veterinary and Animal Sciences, 5(3), 104-108.

Lakshmi, K., & Padmaja, K. (2021). Clinico-pathological evaluation of hepatobiliary disorders in dogs. International Journal of Current Microbiology Applied Sciences, 10(2), 1733-1738.

Liu, P.C., Lin, C.N., & Su, B.L. (2022). Clinical characteristics of naturally Babesia gibsoni infected dogs: A study of 60 dogs. Veterinary Parasitology: Regional Studies and Reports, 28, 100675.

Lucy, E., Rajesh, J.B., Konwar, B., Arya, R.S., Prasad, H., Sarma, K., Debnath, A., Nama, D., Bordoloi, K.P., & Deka, C.(2022). Clinico pathological and haemato-biochemical changes associated with immune mediated haemolytic anaemia in dogs. The Pharma Innovation Journal, 11(3), 04-06.

Mittal, M., Kundu, K., Chakravarti, S., Mohapatra, J.K., Singh, V.K., Kumar, B.R., Thakur, V., Churamani, C.P., & Kumar, A.(2019). Canine babesiosis among working dogs of organised kennels in India: A comprehensive haematological, biochemical, clinic

pathological and molecular epidemiological multiregional study. Preventive Veterinary Medicine, 169, 104696.

Obeta, S.S., Ibrahim, B., Lawal, I.A., Natala, J.A., Ogo, N.I., & Balogun, E.O. (2020). Prevalence of canine babesiosis and their risk factors among asymptomatic dogs in the federal capital territory, Abuja, Nigeria. Parasite Epidemiology and Control, 11, 00186.

Preena, P., Sarangom, S.B., Ramesh Kumar, K.V., Seeja, S., & Rajalekshmi, S.(2021). Haematological alterations in large babesia species infection in dogs of Kannur district of Kerala. Journal of Parasitic Diseases, 45(4), 1090-1095.

Reddy, S.B., Sivajothi, S., Varaprasad Reddy, L.S.S., & Solmon Raju, K.G., (2014). Clinical and laboratory findings of

babesia infection in dogs. Journal of Parasitic Diseases, 40(2), 268-272.

Swann, J.W., & Skelly, B.J. (2013). Systematic review of evidence relating to the treatment of immune-mediated hemolyticanemia in dogs. Journal of Veterinary Internal Medicine, 27(1), 1-9.

Thomas, A., AlinMoideen, T.K., Ambily, R., Jayavardhanan, K.K., & Kumar, A. (2019). Haemato-biochemical changes in Babesia gibsoni infection in dogs: A report from Thrissur district, Kerala, India. Journal of Entomology and Zoology Studies, 7(4), 309-311.

Vishnurahav, R.B., Usha, N.P., Ajithkumar, S., & Lucy, S. (2017). Efficacy study of clindamycin as potential monotherapy treatment plan for clinical case of dogs infected with Babesia gibsoni. Malaysian Journal of Veterinary Research, 8, 45-49.

Yao, D.W., Jiang, J.Y., Yu, Z.Z., Yao, D.Q., Yang, D.J., & Zhao, Y.B. (2014). Canine babesiosis in China caused by Babesia gibsoni: A molecular approach. Iranian Journal of Parasitology, 9(2), 163.

Zygner, W., Gójska-Zygner, O., & Norbury, L.J. (2023). Pathogenesis of anaemia in canine babesiosis: Possible contribution of pro-inflammatory cytokines and chemokines - A review. Pathogens, 12(2), 166.

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Published

2024-07-01

How to Cite

Reddy, S.T.C., Chandrashekhariah, A.K.M., Appaiah, K.M., Murag, S., Kumar, K.R.A., & Hanumantha, P.B. (2024). Haemato-Biochemical Changes in Dogs Affected with Immune Mediated Haemolytic Anaemia Caused by Babesia gibsoni . Indian Journal of Veterinary Sciences and Biotechnology, 20(4), 105–109. https://doi.org/10.48165/ijvsbt.20.4.22