Clinico-pathological and Molecular Findings in Canine  Anaplasma phagocytophilum Infection and its Therapeutic  Management

Authors

  • Chandramita Das Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India
  • kalyan sarma Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India
  • Chethan Gollahalli Eregowda Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India
  • Parimal Roychoudhury Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India
  • Arindam Bhowmik Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India
  • Justus Babykutty Rajesh Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih-796015, Aizawl, Mizoram, India

DOI:

https://doi.org/10.48165/ijvsbt.20.3.34

Keywords:

A. phagocytophilum, Anaemia, thrombocytopenia, doxycycline, dog

Abstract

A documented case of canine granulocytic anaplasmosis coupled with the molecular characterization of the etiological agent isreported for the first time in Aizawl district of Mizoram. A 4-year-old female Golden Retriever presented to a Teaching Veterinary Clinical Complex, CAU, Selesih, Mizoram showed nonspecific clinical signs such as fever and weight loss. The mostrelevant clinicopathological findings were fever, tachycardia, tachypnea, pale mucous membranes, dehydration, haemorrhage, and hind limb pain. anaemia, leukocytosis, lymphocytosis, monocytopenia, eosinopenia, and mild thrombocytopenia. Serum biochemistry indicated elevated ALT, ALP, total bilirubin, indirect bilirubin, BUN, and CRP. Urine analysis revealed proteinuria, bilirubinuria, and haematuria. The oxidative stress indices revealed decreased TAOA and SOD, and increased LPO levels. Blood smear examination revealed the presence of intracytoplasmatic inclusions in neutrophils associatedwithhigh positive serology for Anaplasmaphagocytophilum. Species-specific PCR analysis confirmed serological diagnosisof A. phagocytophilum.Data indicates that A. phagocytophilum circulates in natural environments of the northeast region of India and its prevalence in dogs could be underestimated because the clinical signs are frequently nonspecific and a certain diagnosisrequires the combination of clinicopathological and molecular assays. Pets living in this area should be regularly monitored andtreated for ectoparasites to minimize health risks for humans and pets.

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Published

2024-05-10

Issue

Vol. 20 No. 3 (2024): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (May-Jun) 2024

Section

Short Communication

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Copyright (c) 2024 Indian Journal of Veterinary Sciences and Biotechnology

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Das, C., sarma, kalyan, Eregowda, C.G., Roychoudhury, P., Bhowmik, A., & Rajesh , J.B. (2024). Clinico-pathological and Molecular Findings in Canine  Anaplasma phagocytophilum Infection and its Therapeutic  Management. Indian Journal of Veterinary Sciences and Biotechnology, 20(3), 171–175. https://doi.org/10.48165/ijvsbt.20.3.34
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