Comparison Of Efficacy Of Intravenous Dexmedetomidine Vs Clonidine Vs Tramadol To Control Post Spinal Shivering In Parturiants Undergoing Elective Lscs

Authors

  • Manisha Kapdi Ex Associate professor of anaesthesia, NHLM Medical college Ahmedabad Gujarat India
  • Aishwarya Raj present Associate professor of Anaesthesia, AMCMET Medical college Ahmedabad Gujarat
  • Uma Santoli Resident in Anaesthesia AMCMET Medical college, Ahmedabad Gujarat

DOI:

https://doi.org/10.48165/ijabms.2021.233710

Keywords:

Iv Clonidine, Iv Dexmedetomidine, I.v Tramadol, Lscs, Parturients. Post Spinal Shivering

Abstract

INTRODUCTION: – Post spinal shivering is very unpleasant, uncomfortable to the 55% population of parturient. Shivering is spontaneous, involuntary, rhythmic, tremor-like muscle hyperactivity that  increases metabolic heat production up to 600% after general or regional anaesthesia. There  are various methods available to control shivering during anaesthesia. We conducted this both  drugs control post spinal shivering. In present study to compare the relative efficacy of Dexmedetomidine, Clonidine and  Tramadol for control of intraoperative shivering under spinal anaesthesia Study design: Randomized double blind Observation study. AIMS AND OBJECTIVES: – The present study is undertaken to clinically compare the efficacy, haemodynamic effects,  complications and side effects of Dexmedetomidine, Clonidine & Tramadol on control of post  spinal shivering in parturient. METHODS: – After obtaining written informed consent, we conducted a randomised study in 90 parturient (30 in each group) and compared the efficacy of intravenous Dexmedetomidine Clonidine and  Tramadol for controlling post spinal shivering. Patients were given inj. Dexmedetomidine (Group D) 0.5mcg/kg, Injection clonidine (Group  C I.V. Clonidine 0.5mcg/kg), Tramadol (Group T- I.V. Tramadol 1mg/kg) when shivering of  grade 2 to 4 was noted which lasted for minimum periof of 2 minutes after institution of  subarachnoid block. CONCLUSION: Dexmedetomidine, Clonidine& Tramadol effectively treated patients with  post spinal shivering, but time taken for complete cessation of shivering was earlier in  Tramadol. From our study we conclude that, I.V Tramadol is a better alternative than I.VAlpha 2agonists (Dexmedetomidine & Clonidine) in treatment of post spinal anaesthesia shivering

References

Ozaki M, Kurz A, Sessler DI, Lenhardt R, Schroeder M, Moayeri A, et al. Thermoregulatory thresholds during spinal and epidural Anaesthesia. Anesthesiology 1994; 81:282-8.

Atashkhoyi S, Negargar S. Effect of Tramadol for prevention of shivering after spinal anaesthesia for cesarean section.Research Journal of Biological Sciences. 2008; 3:1365-1369.

Bhatnagar S, Saxena A, Kannan TR, Punj J, Panigrahi M, Mishra S. Tramadol for postoperative shivering: A double blind comparison with Pethedine. Anaesth Intensive care. 2001; 29:149-54.

Bhattacharya PK, Bhattacharya L, Jain RK, Agarwal RC. Post anaesthesia shivering (PAS); A Review, Indian journal of anaesthesia 2003; 47(2);88-93

Bilotta F, Pietropaoli P, Sanita R, Liberatori G, Rosa G. Nefopam and Tramadol for the prevention of shivering duringneuraxial anaesthesia. Regional anaesthesia pain med 2002; 27:380-4

Brauchi S et al. A hot sensing cld receptor: C-terminal domain determines thermos sensation in transient receptor potential channels. J Neuroscience 2006; 26: 4835 - 40

Buggy DJ. Crossley AWA. Thermoregulation, mild perioperative hypothermia and post anaesthetic shivering. British Journal of Anaesthesia 2000; 84 (5) :615-2

Capogna GI, Celleno D: I.V Clonidine for extradural shivering in parturient: a preliminary study. Br J Anaesth. 1993Aug;71(2):294-5

Chaturvedi S, Domkondwar G. Control of shivering under regional anaesthesia using Tramadol. Asian archives of anaesthesiology and resuscitation 2002; 57:491-6

De Whitte, Sessler DI. Perioperative shivering: Physiology andPharmacology.Anaesthesiology.2002;96:467-84.

Dhimar AA, Patel MG, Swadian VN. Tramadol for control of shivering: comparison with Pethidine. Indian J Anaesthesia.2007;51:28-31.

V Aravind, M. Dhakshinamoorthy, C. Dhanasekharan: Comparison of clonidine/ Tramadol for post Spinal Anaesthesia shivering. International Journal of Modern Research & Review: Volume 2, October 2014 issue 10, PP 379-384

Filos KS, Goudas LC, Patroni O, Polyzou V. Hemodynamic and analgesic profile after intrathecal Clonidine in humans. A dose-response study. Anesthesiology. 1994; 81:591-601.

Hervey GR, Thermoregulation. In: emsile-smith D, Paterson C, scatcherd T, Read N, eds . textbook of physiology, 11thedition. Edinburgh: Churchill -livingstone, 1988;510-33.

pranav Bansal, Gaurav Jain: control of shivering with clonidine, Buterophenol, Tramadol under spinal anaesthesia, A comparative study. Local Regional anaesthesia,2011;4:29-34

Attal Prerna, AkhileshChhaya,Ram Upadhyay: Comparison of clonidine/ Tramadol for control of shivering under Spinal anesthesia. International journal of Biomedical & Advanced Reaserch2015;6(01):25-31

Mercadante S, De Michele P, Letterio G Pignataro A, Sapio M, Villari P: effect of Clonidine on postpartum shivering after epidural analgesia; a randomised, controlled, double blind study. J Pain symptom manage. 1994 Jul;9(5):29

Anne Miu Han Chan, kwok fu. Control of shivering under regional anaesthesia in obstetric patients with Tramadol. Can Janaesth 199; 46(3):253-8

Reddy VS, Chiruvella S. Clonidine versus Tramadol for post spinal shivering during caesarean section: A randomized double blind clinical study. J Obstet Anaesth Crit Care 2011; 1:26 -29.

Shukla U, Malhotra K, Prabhakar T. A comparative study of the effect of Clonidine and Tramadol on post spinal anaesthesia shivering. Indian J Anaesth 2011; 55:242 - 6.

Christina Lamontagne. Sandra Lesage, Edith Villeneuve, Elsa Lidzborski, Alex Derstenfeld, Chantal Crochetie`re. Intravenous Dexmedetomidine for the treatment of shivering during Cesarean delivery under neuraxial anesthesia: a randomized-controlled trialCan J Anesth/J Can Anesth (2019) 66:762–771 https://doi.org/10.1007/s12630-019-0

Abdel-Ghaffar HS, Mohamed SA, Fares KM, Osman MA. Safety and efficacy of Dexmedetomidine in treating post spinal anesthesia shivering: a randomized clinically controlled dose finding trial. Pain Physician 2016; 19: 243-53.

Rajagopalan Venkatraman et al.A prospective, randomized, double-blinded control study on comparison of tramadol, clonidine and Dexmedetomidine for post spinal anesthesia shivering] Rev Bras Anestesiol. Jan-Feb 2018.

Dr. Niranjan Kumar Verma, Dr. Mahesh Kumar. Comparison of Clonidine, Dexmedetomidine and Tramadol for Control of Post Spinal Shivering: A Randomized Double Blind Clinical Study November 2016International Journal of Pharmaceutical and Life Sciences 2(6):658-664.

Published

2021-08-25

How to Cite

Comparison Of Efficacy Of Intravenous Dexmedetomidine Vs Clonidine Vs Tramadol To Control Post Spinal Shivering In Parturiants Undergoing Elective Lscs. (2021). Indian Journal of Applied-Basic Medical Sciences, 23(37), 122–135. https://doi.org/10.48165/ijabms.2021.233710