Comparison Of Fentanyl And Clonidine In Attenuation Of  Haemodynamic Response To Laryngoscopy And Endotracheal  Intubation

Vishva Darshanbhai  Shah; Jyotsana  Sirohi; Gargi Mayur  Bhavsar; Devanshi Jiteshbhai  Shah

doi:10.48165/ijabms.2021.23118

Authors

Vishva Darshanbhai Shah Ex anesthesia resident, NHLMMC, Ahmedabad, tutor at present in anesthesia department at AMCMET Medical college, Ahmedabad
Jyotsana Sirohi 3rdyear resident, Smt. NHL MedicalCollege, Ahmedabad Address: Flat-802, F wing, mahima elanza, patrakar colony, near Man Sarovar, Jaipur, Rajasthan 302029.
Gargi Mayur Bhavsar Ex Assistant professor, NHLMMC, Ahmedabad, Associate Professor at present in anesthesia department at AMCMET Medical college, Ahmedabad
Devanshi Jiteshbhai Shah first year anesthesia resident, AMCMET Medical college, Ahmedabad

DOI:

https://doi.org/10.48165/ijabms.2021.23118%20

Keywords:

Laryngoscpoy, endotracheal intubation, pressor response, Clonidine, Fentany

Abstract

Background: Laryngoscopy and endotracheal intubation has led to provision of safer anaesthesia due to better control of airway and ventilation. It is associated with reflex sympathetic stimulation resulting in an increase in heart-rate and blood-pressure, which is known as pressor response to laryngoscopy and intubation. Various drugs have been used to avoid this pressor response. This study was aimed to assess the effects of IV Fentanyl and IV Clonidine on pressor responses occurring due to laryngoscopy and intubation in normotensive patients posted for a planned surgical procedure under general anaesthesia.

Methods: Approval from the institutional ethical committee was taken for the study. We conducted this study in 60 patients belonging to ASA grade I and II, of 18 to 65 years of age, of either sex, scheduled for planned surgical procedures under general anaesthesia.

Patients were randomly allocated into 2 groups; the study drug was injected IV slowly 10 mins before induction. Group-F: received Inj Fentanyl 2mcg/kg

Group-C: received Inj. Clonidine 2mcg/kg

Observations were noted in terms of heart-rate, systolic-BP, diastolic-BP, mean-BP and spO2. Results: We observed that Clonidine pre-treatment provided better blunting of stress response during laryngoscopy and intubation without causing clinically significant sedation, respiratory depression, bradycardia or hypotension compare to Fentanyl.

Conclusion:

We came to a conclusion that Clonidine provided better response compare to Fenatanyl in obliterating the rise in heart-rate and blood pressure on laryngoscopy and intubation.