Anti-inflammatory, Anti-nociceptive and Toxicity Studies of Homoeopathic Formulation Rück-Pain™ Against Spondylitis

Authors

  • Rohit Bhardwaj B Pharm, M Pharm Scholar, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India. Pin – 201303
  • Amit Kumar Mittal PhD, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India. Pin – 201303
  • Nitesh Sharma BHMS, Scientific Officer, Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, Uttar Pradesh, India. Pin – 201304
  • Swati Madan PhD, Assistant Director, Amity Institute of Indian System of Medicine, Amity University, Noida, Uttar Pradesh, India. Pin – 201303
  • Harsha Kharkhwal PhD, Director, Amity Institute of Phytomedicine and Phytochemistry, Amity University, Noida, Uttar Pradesh, India. Pin – 201303
  • Satyendra Kumar Rajput PhD, Director, Amity Institute of Indian System of Medicine, Amity University, Noida, Uttar Pradesh, India. Pin – 201303
  • Ramachandran Valavan MD (Hom), Head – Scientific & Medical Affairs, Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, Uttar Pradesh, India. Pin – 201304

Keywords:

homoeopathic, pharmacopoeia, Anti-inflammatory, (ANOVA), Anti-nociceptive

Abstract

Introduction: Spine-related problems are continuously increasing due to current lifestyle, environmental and genetic factors. Lifestyle factors like prolonged sitting, lack of exercise and wrong posturefurther aggravate these problems. A homoeopathic formulation Rück Pain™ was developed to treat the symptoms arising from spinal disorders and surrounding regions. Its ingredients are covered by homoeopathic pharmacopoeia (s) and authoritative literature. 

Objective: The current study aimed to evaluate the anti-inflammatory, anti-nociceptive and toxicity effects of Rück-Pain™ in mice animal model. 

Materials and methods: Swiss albino mice were divided into 6 groups viz. vehicle control, disease control, treatment dose 1 (2.96ml/kg), treatment dose 2 (6ml/kg), treatment dose 3 (8.80ml/kg) and standard treatment. Spondylitis was induced by the administration of Sodium thioglycolate 0.1ml (1% solution) at neck joint region of mice. Anti-inflammatory effect was evaluated by measuring erythrocyte sedimentation rate (ESR) and area of inflammation in volume in the neck region by Vernier caliper. Anti nociceptive effect was evaluated using tail-flick assay. Histological changes in liver and spleen were assessed to find out the toxicity by the treatment groups. Statistical analysis was done using one-way analysis of variance (ANOVA) considering P=<0.05 as significant. 

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Published

2022-08-24

Issue

Vol. 5 No. 1 (2020): Advancements in Homeopathic Research (Feb-Apr) 2020

Section

Articles

How to Cite

Anti-inflammatory, Anti-nociceptive and Toxicity Studies of Homoeopathic Formulation Rück-Pain™ Against Spondylitis. (2022). Advancements in Homeopathic Research, 5(1), 13–19. Retrieved from https://acspublisher.com/journals/index.php/ahr/article/view/1915