In Vivo Anti-Inflammatory Potential, Minimum Inhibitory Concentration And Minimum Bactericidal Concentration Of Ferulic Acid, Isolated From Pineapple Waste

Authors

  • Lubaina Abdulhadeef Shereefa PG and Research Department of Botany, Christian College, Kattakada, Thiruvananthapuram - 695 572, Kerala (India)
  • Renjith Raveendran PG and Research Department of Botany, Christian College, Kattakada, Thiruvananthapuram - 695 572, Kerala (India)
  • Ragesh R Nair PG Department of Botany, Iqbal College, Peringammala, Thiruvananthapuram - 695 563, Kerala (India)
  • Praveen Kumar PG and Research Department of Zoology, Government College for Women, Thiruvananthapuram – 695 014, Kerala (India)

Keywords:

Ferulic acid, in-vivo anti-inflammatory potential, pineapple waste, Pseudomonas aeruginosa, Staphylococcus aureus

Abstract

Compounds isolated from organic waste are used as a source for the discovery  of new entities against inflammation. Pineapple peel, a by-product of pineapple  processing industry, is a thrown away waste. The current work aimed to study  the in-vivo anti-inflammatory potential and determination of minimum  inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ferulic acid - a phenolic acid isolated from the pineapple peel.  Pseudomonas aeruginosa (ATCC 27853), Klebsiella pneumoniae (ATCC 700603),  Bacillus cereus (ATCC 10876) and Staphylococcus aureus (ATCC 33591) were  used for MIC and MBC study. Acute toxicity screened after giving graded doses  of ferulic acid and analysed it’s in vivo anti-inflammatory potential using  carrageenin induced paw oedema and xylene induced ear oedema in Wistar rats.  NaCl and Indomethacin were used as both negative and positive controls,  respectively. The isolated phenolic compounds significantly reduced  inflammation at all the dose tested. From the study it may be concluded that the  phenolic compound isolated from pineapple peel exhibit significant anti inflammatory activities and display strong bactericidal potentiality against Staphylococcus aureus and Pseudomonas aeruginosa indicating its anti inflammatory and bactericidal potential.  

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References

Amri, O., Zekhnini, A., Bouhaimi, A., Tahrouch, S. and Hatimi, H. 2018. Anti-inflammatory activity of methanolic extract from Pistacia atlantica Desf. leaves. Pharmacognosy Journal, 10: 71-76. Arora, R. and Gill, N.S. 2021. Evaluation of anti-inflammatory activity of Trichosanthes dioica Roxb. seeds. International Journal of Pharmaceutical Sciences and Drug Research, 13: 263-267. Burt, S. 2004. Essential oils: Their antibacterial properties and potential application in foods - A review. International Journal of Food Microbiology, 94: 223-253.

Dubin, S.B. 1998. Assessment of fetal lung maturity: Practice parameter. American Journal of Clinical Pathology, 110: 723-732.

Gill, A.O. and Holley, R.A. 2006. Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics. International Journal of Food Microbiology, 108: 1-9.

Gupta, D., Verma, N., Das, H.R. and Gupta, R.K. 2014. Evaluation of anti-inflammatory activity of Dracaena cinnabari Balf. f. resin. Indian Journal of Natural Products and Resources, 5: 215- 222.

Lin, C., Lin, W., Chang, C. and Namba, T. 1995. Anti-inflammatory and hepatoprotective effects of Ventilago leiocarpa. Phytotherapy Research, 9: 11-15.

Ma, Y., Li, Y., Li, X. and Wu, Y. 2013. Anti-inflammatory effects of 4-methyl cyclopentadecanone on edema models in mice. International Journal of Molecular Sciences, 14: 23980-23992. Mogana, R., Adhikari, A., Tzar, M.N., Ramliza, R. and Wiart, C. 2020. Antibacterial activities of the extracts, fractions and isolated compounds from Canarium patentinervium Miq. against bacterial clinical isolates. BMC Complementary Medicine and Therapies, 20: 55-62.

Anti-inflammatory potential of ferulic acid from pineapple waste 43

Mostafa, A.A., Al-Askar, A.A., Almaary, K.S., Dawoud, T.M., Sholkamy, E.N. and Bakri, M.M. 2018. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi Journal of Biological Sciences, 25: 361-366.

Murray, P.R. and Zeitinger Y.R. 1983. Evaluation of Mueller-Hinton agar for disk diffusion susceptibility tests. Journal of Clinical Microbiology, 18: 1269-1271.

Nath, P. and Yadav, A.K. 2015. Acute and sub-acute oral toxicity assessment of the methanolic extract from leaves of Hibiscus rosa-sinensis L. in mice. Journal of Intercultural Ethnopharmacology, 4: 1-4.

Panthong, A., Supraditaporn, W., Kanjanapothi, D., Taesotikul, T. and Reutrakul, V. 2007. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. Journal of Ethnopharmacology, 110: 264-270.

Parveen, Z., Deng, Y., Saeed, M.K., Dai, R., Ahamad, W. and Yu, Y.H. 2007. Antiiflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside. Yakugaku Zasshi Journal of the Pharmaceutical Society of Japan, 127: 1275-1279.

Roy, P., Amdekar, S., Kumar, A. and Singh, V. 2011. Preliminary study of the antioxidant properties of flowers and roots of Pyrostegia venusta (Ker Gawl) Miers. BMC Complementary Medicine and Therapies, 11: 69-73.

Sharma, V.C., Kaushik, A., Dey, Y.N., Srivastava, B., Wanjari, M. and Jaiswal, B. 2020. Analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of stem bark of Anogeissus latifolia Roxb. Clinical Phytoscience, 6: 22-28.

Suba, V., Murugesan, T., Kumaravelrajan, R., Mandal, S.C. and Saha, B.P. 2005. Anti-inflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. extract. Phytotherapy Research, 19: 695-699.

Zhang, Z., Luo, P., Li, J., Yi, T., Wang, J., An, J. and Zhang, H. 2008. Comparison of the anti inflammatory activities of three medicinal plants known as “Meiduoluomi” in Tibetan folk medicine. Yakugaku Zasshi Journal of the Pharmaceutical Society of Japan, 128: 805-810.

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Published

2023-02-02

Issue

Vol. 25 No. 1 (2023): Applied Biological Research (Jan) 2023

Section

Review Articles

How to Cite

In Vivo Anti-Inflammatory Potential, Minimum Inhibitory Concentration And Minimum Bactericidal Concentration Of Ferulic Acid, Isolated From Pineapple Waste . (2023). Applied Biological Research, 25(1), 36–43. Retrieved from https://acspublisher.com/journals/index.php/abr/article/view/11623