Drug Interactions Xenobiotic Metabolism: Edited by Alice Kunek

Acute behavioural effects of co-administration of the illegal drug 3,4 methylenedioxymethamphetamine (MDMA, 7.5.mg/kg, s.c.) and the synthetic cannabinoid receptor agonist WIN55212-2 (WIN, 1.2mg/kg, i.p.) in rats were investigated. MDMA impaired performance on a T-maze effort-based decision making task. MDMA and MDMA+WIN treatment increased body temperature to a similar extent, whereas WIN increased temperature at an earlier time point. Locomotion, exploratory behaviour and food intake was comparable in MDMA and MDMA+WIN-treated animals. MDMA- the cannabinoid receptor agonist did not substantially modulate the MDMA-induced behavioural effects.