The Comorbidities and it Impact on the outcome of COVID-19 Patients

Alaa Hussein Khudhair  Al-Janabi

doi:10.48165/sajssh.2023.4603

Authors

Alaa Hussein Khudhair Al-Janabi Department of epidemiology, Directorate of Health, Ministry of Health, Babylon, Iraq.

DOI:

https://doi.org/10.48165/sajssh.2023.4603

Keywords:

Comorbidities, COVID-19, Hypertension, Diabetes, Babylon

Abstract

Background: The existence of associated diseases presents a major clinical challenge in the approach and management of COVID-19 patients. Objectives: To study the effect of common comorbidities on the severity, outcome, and duration of hospital stay among confirmed COVID 19 cases. Methods: Descriptive cross-sectional study. A 2574 conditions were involved in the current study. All the PCR confirmed cases in 2 COVID-19 centers at Babylon province/Iraq were included for the period from March till September 2020. A constructed questionnaire used as a method of data collection which including socio-demographic data, clinical presentation of the infection and its severity, associated comorbidities that the patient may suffer from and the duration of hospital stay and outcome. Results: the study shown that the mean of age 48.7 (±16.4) years, Diabetes Mellitus was the most prevalent associated comorbidity (25.0%), then hypertension with a prevalence of (23.4%), (84.0%) of the patients who had comorbidities had severe/critical illness compared to (54.1%) for patients who are free from comorbid illnesses with significant P value of (0.001), case-mortality ratio was 26.4% among patients with comorbidities compared to 10.6% among the patients free from comorbidity (P<0.001). Conclusions: associated diseases had significant impact on the severity of the duration and outcome of COVID-19 infection, patients with comorbidities must have additional preventive measures and they should be at the beginning in receiving the COVID-19 vaccine to prevent the deteriorations and bad consequences.

References

Alguwaihes AM, Al-Sofiani ME, Megdad M, Albader SS, Ansari MH, Alelayan A, Alzahrani SH, Sabico S, Al-Daghri NM, Jammah AA. (2020). Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-center retrospective study. Cardiovascular diabetology. Dec;19(1):1-2.

Ashraf, A., Ishfaq, K., Ashraf, M. U., & Ali, J. (2019). Revisiting the Role Parenting Styles on Personality Development of Adolescents: A Study of District Multan, Southern Punjab, Pakistan. Journal of Languages, Culture and Civilization, 1(1), 11-26.

Ashraf, M. U., Ahmad, A. H. B., & Azlizan, B. T. (2019). The Role of Parenting and Peer Pressure in the Development of Juvenile Delinquent Behaviour among Higher Secondary School Children in Punjab, Pakistan: A Proposed Framework. International Journal of Innovation, Creativity and Change (IJICC), 7(5).

Chee, Y. J., Tan, S. K., & Yeoh, E. (2020). Dissecting the interaction between COVID‐19 and diabetes mellitus. Journal of diabetes investigation, 11(5), 1104-1114.

Chen WW, Gao RL, Liu LS, Zhu ML, Wang W, Wang YJ. (2017). China cardiovascular diseases report 2015: A summary [Internet]. Vol. 14, Journal of Geriatric Cardiology. Science Press; [cited 2021 Jan 30]. p. 1–10.

Chhiba KD, Patel GB, Vu THT, Chen MM, Guo A, Kudlaty E, et al. Prevalence and characterization of asthma in hospitalized and non-hospitalized patients with COVID-19. J Allergy Clin Immunol [Internet]. 2020 Aug 1 [cited 2021Feb10];146(2):307- 314.e4.Available from: https://pubmed.ncbi.nlm.nih.gov/32554082/

Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z (2020). Patients with cancer appear more vulnerable to SARS-CoV-2: A multicenter study during the COVID-19 outbreak. Cancer Discov [Internet]. Jun 1 [cited 2021 Feb 10];10(6):783. Available from: http://cancerdiscovery.aacrjournals.org/

Ejaz, H., Alsrhani, A., Zafar, A., Javed, H., Junaid, K., Abdalla, A. E.& Younas, S. (2020). COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of infection and public health, 13(12), 1833-1839.

Fang L, Karakiulakis G, Roth M. (2020) Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? [Internet]. Vol. 8, The Lancet Respiratory Medicine. Lancet Publishing Group. p. e21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118626/

Ferrer R. COVID-19 Pandemic: the greatest challenge in the history of critical care. Medicina intensiva. 2020 Aug 1.

Henry BM, Lippi G. Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection [Internet]. Vol. 52, International Urology and Nephrology. Springer; 2020 [cited 2021 Jan 30]. p. 1193–4. Available from: https://doi.org/10.1007/s11255-020-02451-9

Higham A, Mathioudakis A, Vestbo J, Singh D. (2020). COVID-19 and copd: A narrative review of the basic science and clinical outcomes. Eur Respir Rev.;29(158):1–13.

Hussain A, Bhowmik B, do Vale Moreira NC. (2020).COVID-19 and diabetes: Knowledge in progress. Vol. 162, Diabetes Research and Clinical Practice. Elsevier Ireland Ltd

Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, Khare S, Srivastava A. (2020). Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews.;14(4):535-45.

Li, L., Sun, W., Han, M., Ying, Y., & Wang, Q. (2020). A study on the predictors of disease severity of COVID-19. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e927167-1.

Liu W, Tao ZW, Wang L, Yuan ML, Liu K, Zhou L (2020). Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J (Engl);133(9):1032–8. Available from: /pmc/articles/PMC7147279/?report=abstract

Moiseev S, Avdeev S, Brovko M, Akulkina L, Fomin V. Cancer in intensive care unit patients with COVID-19 [Internet]. Vol. 81, Journal of Infection. W.B. Saunders Ltd; 2020. p. e124–5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255725/

Ntaios G, Michel P, Georgiopoulos G, Guo Y, Li W, Xiong J, et al. Characteristics and Outcomes in Patients with COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry [Internet]. Vol. 51, Stroke. Lippincott Williams and Wilkins; 2020 [cited 2021 Jan 30]. p. 254–8. Available from: https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031208

Obaid, A. F., Shlash, A. M. J., Abdulrasol, Z. A., & Lafta, M. A. The consequences of COVID-19 and its vaccine on pregnant and lactating mothers. The Egyptian journal of immunology, (2022). 29(4), 58–74. https://pubmed.ncbi.nlm.nih.gov/36197154/

Rees EM, Nightingale ES, Jafari Y, Waterlow NR, Clifford S, Pearson CAB (2020). COVID-19 length of hospital stay: A systematic review and data synthesis. medRxiv.; factors influencing the length of hospital stay among non-severe COVID-19 patients: A retrospective cohort study in a Fangcang shelter hospital. PLoS One [Internet]. 2020 Oct 1 [cited 2021 Jan 31];15(10 October). Available from: /pmc/33.

Suleman, D., & binti Ab Rehman, F. (2020). Transgender Issues in Indian Society from the Viewpoint of Arundhati Roy’s Novel, The Ministry of Utmost Happiness. South Asian Journal of Social Sciences and Humanities, 1(3), 159-172.

Suleman, D., Kashif, A., Tilwani, S. A., & Rabeea, L. K. (2023). Impacts of Unjust Traditional Practices on Unhappy Marriage Life: An Empirical Assessment of the Social Context in the Kurdish Region. Kurdish Studies, 11(1), 145-160.

Suleman, D., Mehmood, W., Iqbal, F., & Ashraf, M. U. (2021). Covid-19 Suicidal Cases in India in the Light of Poverty: Upcoming Challenges for India in Terms of Economy. Review of International Geographical Education Online, 11(10), 2108-2118.

Tadic M, Cuspidi C, Grassi G, Mancia G. (2020). COVID-19 and, arterial hypertension: Hypothesis or evidence? Journal of Clinical Hypertension. Blackwell Publishing Inc.;.

Talib Al Sa'ady, A., Abdulameer Abdulrasol, Z., Fadhil Obaid, A., Abdul-Amir Makki Alhindy, H., & S. Al-Mumin, A. Prevalence of adverse effects from COVID-19 vaccine among Iraqi adults: A retrospective cross-sectional study. Journal of Emergency Medicine, Trauma & Acute Care. (2022). https://doi.org/10.5339/jemtac.2022.ismc.6

Trejo-Gabriel-Galán JM. (2020). Stroke as a complication and prognostic factor of COVID-19 [Internet]. Vol. 35, Neurologia. Spanish Society of Neurology; [cited2021Feb10].p.318– 22. Available from: https://pubmed.ncbi.nlm.nih.gov/32493597/

Wu, S., Xue, L., Legido-Quigley, H., Khan, M., Wu, H., Peng, X. & Li, P. (2020). Understanding factors influencing the length of hospital stay among non-severe COVID-19 patients: A retrospective cohort study in a Fangcang shelter hospital. Plos one, 15(10), e0240959.

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med [Internet].;8(5):475–81. Available from: http://dx.doi.org/10.1016/S2213-2600(20)30079-5