Hepatitis C Patients with Progress of Disease Severity: Biochemical and Immunological studies

Authors

  • N M Abdallah Biochemistry Department, Faculty of Science, Ain Shams University Author
  • R M Yousry Radiobiology Research Department, National Center for Radiation Research and Technology (NCRRT) Atomic Energy Authority (AEA) Author
  • F F Abdel Hamid Biochemistry Department, Faculty of Science, Ain Shams University. Author
  • M N EI- Rouby Department of Cancer Biology, Virology and Immunology Unit, National Cancer Institute, Cairo University, Egypt. Author
  • S M Abdel Fattah Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT) Atomic Energy Authority (AEA) Author

DOI:

https://doi.org/10.48165/

Keywords:

Chronic hepatitis C , liver function , immune system

Abstract

Hepatitis C infection has become epidemic with a rapid increase in the number of patients. Hepatitis C has some streaking among which are; most cases don't correlate with the histological of the hepatic biopsies of these patients. The present study aims at investigating some biochemical and immunological aspects among patients varying in degree of disease severity. The study includes 112 subjects; 24 healthy control and 88 CHC patients, grouped as follows: Group I: (control group), Group II: compensated chronic liver disease (without cirrhosis), Group III: decompensated with liver cirrhosis and Group IV: hepatocellular failure; end stage liver. Results of the present study showed that serum aspartate and alanine transaminases (AST & ALT), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) activities, total and direct bilirubin, globulin, AST/platelet ratio index (APRI), globulin/platelet ratio, tumor necrosis factor-α (TNF-a), interferon-g (IFN-g), interleukins (lL-2 & IL-4), immunoglobulins (lgA, IgM and IgG), concentrations were increased significantly in all CHC patients groups while, albumin, albumin/globulin ratio (AIG ratio), platelets count, multivariate disriminant analysis (MDA) (based on 4 variables, AST/ALT,platelets, ALP & albumin), were decreased significantly in all CHC patients groups compared to the control group. AST/ALT ratio increased in all groupsexcept GroupII.CD4+%wasignificantly low in Group III and Group IV, while CD8+% decreased significantly in Group II & Group IV.It was concluded that biochemical tests in combination with each other could diagnose serious pathological disorders. Furthermore, immune parameters possibly play a role in the degradation process of the liver. Although, immune system components contribute to the liver injury, they maintain low viral load in advanced stages.

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Published

2020-07-20

How to Cite

Hepatitis C Patients with Progress of Disease Severity: Biochemical and Immunological studies. (2020). Journal of Nuclear Technology in Applied Science, 8(1), 67–95. https://doi.org/10.48165/