An Open Labelled Randomized Controlled Parallel Group Clinical Study to Evaluate the Efficacy of Prasarini Sandhanam in Management of Rheumatoid Arthritis
Keywords:
Prasarini sandhanam, Simhanada guggulu, Amavata, Rheumatoid ArthritisAbstract
Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease of unknown aetiology marked by a symmetric, peripheral polyarthritis. The prevalence of Rheumatoid arthritis is approximately 0.8 – 1.0 % in Indian subcontinent, with female to male ratio of 3:1. In Ayurveda, Amavata can be co-related to Rheumatoid arthritis based on its clinical signs and symptoms. Mandagni (hypo functioning of digestive fire) and derangement in Vata (vital force of the body) results in manifestation RA. Aims and Objectives: To evaluate the efficacy of Prasarini Sandhanam (PS) and Simhanada Guggulu (SNG) and compare their efficacies in management of Rheumatoid Arthritis. Materials and methods: In the present study 32 patients were enrolled and the study was completed in 30 patients. The patients were allocated randomly in two groups. Group A was administered with SNG (control group) while Group B was administered with PS (trial group). Results: The effect of treatment on 30th day has shown statistically significant result in group A with p value <0.05 in parameters like pain, stiffness, swelling and warmth in the joints, general signs and symptoms and degree of disease activity score. The effect of treatment in group A did not show statistically significant result in General functional capacity, tenderness in joints and Quality of life of patients through Barthel’s index score with p value > 0.05. On follow up all parameters did not show statistical significance with p value > 0.05. The effect of PS in group B on 30th day have shown statistically highly significant result with p value <0.01 in all parameters whereas on follow up it did not show statistically significant result with p value > 0.05 in all parameters. On comparison, Group B have shown better results than Group A in all the parameters. Conclusion: Both the groups showed statistically significant results but on comparison group B (PS) showed better results than group A (SNG). By the virtue of its aetiology, pathogenesis, clinical signs and symptoms and management, Rheumatoid arthritis bears close resemblance to Amavata and can be tackled effectively on the lines of its management as mentioned in classics.
Downloads
References
Ralston S. Davidson’s Principles and practice of medicine. Penman Ian D, Strachan Mark W.J HRP (editor), 23rd Ed., China: Elsevier; 2018. p. 1003
Dennis.L, Braunwald Eugene. Harrison’s principle of internal medicine. Fauci Anthony s, Stephen L. Hauser, Longo Dan L JLJ (editor), 16th Ed., United states of America: Mc Graw Hill; 2005, p. 1974
Stuart.H. Davidson’s Principles and practice of medicine. Penman Ian D, Strachan Mark W.J HRP (editor), 23rd Ed., China: Elsevier; 2018. p. 1003
Dennis.L, Braunwald Eugene. Harrison’s principle of internal medicine. Fauci Anthony s, Stephen L. Hauser, Longo Dan L JLJ (editor), 16th Ed., United states of America: Mc Graw Hill; 2005, p. 1974
Tripathy B, Madhava, Madhava Nidana, (editor), Madhukosha commentary by Vijayarakshita, Shrikantadatta. 1st Ed., Ch 25, Ver. 1-5, Varnasi: Chaukhamba Surbharati Prakashan; 2012, p. 571
Tripathy B, Madhava, Madhava Nidana, (editor), Madhukosha commentary by Vijayarakshita, Shrikantadatta. 1st Ed., Ch 25, Ver. 1-5, Varnasi: Chaukhamba Surbharati Prakashan; 2012, p. 571
Stuart.H. Davidson’s Principles and practice of medicine. Penman Ian D, Strachan Mark W.J HRP (editor), 23rd Ed., China: Elsevier; 2018. p. 1025
Datta C. Chakradatta. Indradev Tripathy (editor). 2nd Ed., Ch 25, Ver. 27 Varnasi; Chaukhamba Surbharati Prakashan; 2010. p. 168
Babu Dss, Agnivesha. Anjana Nidana. Babu DSS (editor). 1st Ed., Varanasi: Chaowkhamba Sanskrit series; 2004. p. 29
Tripathy B, Madhava, Madhava Nidana, (editor), Madhukosha commentary by Vijayarakshita, Shrikantadatta. 1st Ed., Ch 25, Ver. 1-5, Varnasi: Chaukhamba Surbharati Prakashan; 2012, p. 575
Shwetha. A. Pandey, Nayan . P. Joshi, Dilip.M.Pandya. Clinical efficacy of Shiva Guggulu and Simhanada Guggulu in Amavata (Rheumatoid arthritis): AYU Journal. 2012; Apr-Jun; 33(2): 247-254.
Khushbu C, Patel Anar, Patel Mayuree, Macwan Carol. Paederia foetida Linn. As a potential medicinal plant : A Review. Journal of Pharmacy Research. 2010; 3(12): 3135-3137
Arreola R, Quintero-Fabián S, Lopez-Roa RI, Flores Gutierrez EO, Reyes-Grajeda JP, Carrera-Quintanar L, et al. Immunomodulation and anti-inflammatory effects of
garlic compounds. Journal of Immunology Research. Hindawi Publishing Corporation. 2015; 2015: 401630 14. Chaudhary A, Dalvi M, Singh N, Wele A. A progressive review of Sandhana kalpana (Biomedical fermentation): An advanced innovative dosage form of Ayurveda. AYU (An Int Q J Res Ayurveda). 2011; 32(3): 408.
Aftan L Hassett, Daniel J Clauw. The role of stress in rheumatic diseases. Arthritis Research and Therapy. 2010; 12(3): 123
Ramakrishna M. Review on concept of day sleeping w.s.r. to charak samhita. Global Journal for research Analysis. 2019; 8 (9): 71
Dennis.L, Braunwald Eugene. Harrison’s principle of internal medicine. Fauci Anthony s, Stephen L. Hauser, Longo Dan L JLJ (editor), 16th Ed., United states of America: Mc Graw Hill; 2005, p. 1974
Acharya YT, Agnivesha, Charaka Samhita, Ayurveda Dipika commentary by Datt. C. 2nd Ed., Sutra Sthana, 26/4, Varanasi: Chaukhamba Surbharati Prakashan; 2008. 144 p.
Agnivesha, Charaka Samhita, Acharya YT (editor), Ayurveda Dipika commentary by Datt. C. 2nd Ed., Sutra Sthana, 26/5, Varanasi: Chaukhamba Surbharati Prakashan; 2008. p. 145
Chaudhary A, Dalvi M, Singh N, Wele A. A progressive review of Sandhana kalpana (Biomedical fermentation): An advanced innovative dosage form of Ayurveda. AYU(An Int Q J Res Ayurveda). 2011; 32(3): p. 408.
Ravishankar.B, Bhavsar GC: Investigation of the anti inflammatory effects of paederia-foetida: Journal of Ethnopharmacology. June1994; 43(1) p. 31-38
Md. Eyazul Haque, Anath Chandra Roy, Moly Rani. Review on Phytochemical and Pharmacological Investigation of Piper chaba Hunter. International Journal of Scientific & Engineering Research. March-2018; 9(3).
Vishnukanta A. C., Plumbago zeylanica: A phytopharmacological review. International journal of Pharmaceutical sciences and research. Febraury 2011; p. 247-255.
Rehman R, Zingiber officinale Roscoe (pharmacological activity). Journal of medicinal plant research. 4 February, 2011; 5(3), p. 344-348.
Arreola R, Quintero-Fabián S, Lopez-Roa RI, Flores Gutierrez EO, Reyes-Grajeda JP, Carrera-Quintanar L, et al. Immunomodulation and anti-inflammatory effects of garlic compounds. Journal of Immunology Research. Hindawi Publishing Corporation; 2015; 2015: 401630
