Clinical Evaluation of Tiletamine-Zolazepam CRI with Isoflurane Anesthesia in Dog

Authors

  • Harshwardhan Chandrakant Patil Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Parbhani-413401, MAFSU, Nagpur, Maharashtra, India
  • Sharad Dnyandeo Chepte Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Parbhani-413401, MAFSU, Nagpur, Maharashtra, India
  • S Sajid Ali Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Parbhani-413401, MAFSU, Nagpur, Maharashtra, India
  • Nitin Dadarao Jadhav Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Parbhani-413401, MAFSU, Nagpur, Maharashtra, India
  • Ganesh Govindrao Karad Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Parbhani-413401, MAFSU, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.48165/ijvsbt.19.5.21

Keywords:

Constant rate infusion (CRI), Dog, Isoflurane, Tiletamine- Zolazepam, Zoletil

Abstract

The study was conducted to evaluate two anesthetic protocols in 12 clinical cases of dogs presented to Veterinary Clinical Complex, COVAS, Parbhani for elective surgeries. These cases were divided into two equal groups (n=6). In both groups, dogs were pre-medicated with inj. Xylazine @ 1 mg/kg intramuscularly and anaesthesia was induced with inj. Tiletamine- Zolazepam (2 mg/kg) intravenously. Anaesthesia was maintained on constant rate infusion (CRI) of Tiletamine-Zolazepam (@ 2 mg/kg/h) in the dogs of group 1 and on Isoflurane in the dogs of group 2. Anaesthesia was assessed based on the quality of induction and recovery time in both groups. Clinico-physiological and haemato-biochemical parameters were measured in both groups at 5 different intervals. The induction score was identical in both groups with prolonged recovery in group 1. Clinico-physiological and haemato-biochemical values were changed from the base line value and return towards the baseline at recovery in both groups. 

Downloads

Download data is not yet available.

References

Aminkov, B., Mehandzhiyski, N., Aminkov, K., & Peev, I. (2018). Effects of total intravenous anesthesia on hematology and biochemistry values during health checkup in brown bears (Ursus arctos). Tradition and Modernity in Veterinary Medicine, 2(5), 94-99.

Brammer, D.W., Doerning, B.J., Chrisp, C.E., & Rush, H.G. (1991). Anesthetic and nephrotoxic effects of telazol in New Zealand white rabbits. Laboratory Animal Science, 41(5), 432-435.

Docquier, M. A., Lavand’homme, P., Ledermann, C., Collet, V. & De Kock, M. (2003). Can determining the Minimum Alveolar anesthetic concentration of volatile anesthetic be used as an objective tool to assess antinociception in animals? Anesthesia and Analgesia, 97(4), 1033-1039.

Doerning, B.J., Brammer, D.W., Chrisp, C.E., & Rush, H.G. (1992). Nephrotoxicity of tiletamine in New Zealand white rabbits. Laboratory Animal Science, 42(3), 267-269.

Dyson, D. H. (2008). Perioperative pain management in veterinary patients. Veterinary Clinics of North America: Small Animal Practice, 38(6), 1309-1327.

Hafez, S.G., Nouh, S.R., & Elkammar, M.H. (2017). Evaluation of total intra-venous anesthesia using ketamine HCl or telazol in Mongrel dogs. Alexandria Journal for Veterinary Sciences, 53(2), 99-106.

Jena, B., Das, J., Nath, I., Sardar, K.K., Sahoo, A., Beura, S.S., & Painuli, A. (2014). Clinical evaluation of total intravenous anaesthesia using xylazine or dexmedetomidine with propofol in surgical management of canine patients. Veterinary World, 7(9), 671-680.

Karasu, A., Altuğ, N., Aslan, L., Bakir, B., & Yüksek, N. (2018). Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits. Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice,74(10), 646-652.

Koli, P.H., Parikh, P.V., Mahla, J.K., & Barot, H.M. (2021). Clinical attributes of tiletamine-zolazepam induced anesthesia with and without xylazine premedication in dogs. Indian Journal of Veterinary Sciences and Biotechnology, 17(4), 61-65.

Li, L., Dong, J., Lu, D., Jiang, S., Lin, D., & Fan, H. (2012). Effects of tiletamine-zolazepam-xylazine-tramadol combination on biochemical and haematological parameters in cats. Journal of Veterinary Research, 56(3), 369-372.

Lu, D.Z., Jiang, S., Yu, S.M., & Fan, H.G. (2014). A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam/xylazine and tiletamine-zolazepam/ xylazine/ tramadol in dogs. Pakistan Veterinary Journal, 34(1), 63-67.

Manasa, M.R., Dileepkumar, K.M., Anoop, S., Ramankutty, S., Beena, V., & John Martin, K.D. (2021). Evaluation of haematological and serum biochemical profile of propofol-induced isoflurane anaesthesia in geriatric dogs premedicated with diazepam and butorphanol. Journal of Veterinary and Animal Sciences, 52(1), 81-84.

Nam, S.W., Shin, B.J., & Jeong, S.M. (2013). Anesthetic and cardiopulmonary effects of butorphanol-tiletamine-zolazepam-medetomidine and tramadol-tiletamine-zolazepam-medetomidine in dogs. Journal of Veterinary Clinics, 30(6), 421-427.

Pereira, S.A., Henrique, F.V., Medeiros, L.K., Silva, J.K., Goes, A.B., Vaz, A.F., & Nóbrega, P.I. (2019). Anesthetic quality and cardiovascular and respiratory effects of continuous intravenous infusion of tiletamine-zolazepam in bitches. Pesquisa Veterinária Brasileira, 39(3), 214-220.

Phutthachalee, S., Cherdchutham, W., Laikul, A., Phetudomsinsuk, K., Chanda M., & Phukudom, S. (2012). Comparison of the anesthetic effects of tiletamine HCl–zolazepam–xylazine and ketamine–diazepam–xylazine in older foals under field conditions. Agriculture and Natural Resources, 46(2), 190-199.

Ratnu, D.A., Parikh, P.V., & Kelawala, D.N. (2021). Effects of tiletamine-zolazepam and isoflurane for induction and maintenance in xylazine premedicated dogs. The Indian Journal of Veterinary Sciences and Biotechnology, 17(4), 86-88.

Tabuchi, Y., Shinka S., & Ishida, H. (1989). The effects of anesthesia and surgery on count and function of neutrophils. Journal of Anesthesia, 3(2), 123-131.

White, K.L., Shelton, K., & Taylor, P.M. (2001). Comparison of diazepam–ketamine and thiopentone for induction of anaesthesia in healthy dogs. Veterinary Anaesthesia and Analgesia, 28(1), 42-48.

Published

2023-09-10

How to Cite

Patil, H.C., Chepte, S.D., Ali, S.S., Jadhav, N.D., & Karad, G.G. (2023). Clinical Evaluation of Tiletamine-Zolazepam CRI with Isoflurane Anesthesia in Dog. Indian Journal of Veterinary Sciences and Biotechnology, 19(5), 101–104. https://doi.org/10.48165/ijvsbt.19.5.21