Effect of Piperine on Cypermethrin-Induced Genotoxicity in  Wistar Rats

Authors

  • Palanisamy Sankar Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal - 637002, Tamil Nadu, India
  • Avinash G Telang Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar- 243122, Bareilly, Uttar Pradesh, India
  • Kalaivanan Ramya Department of Veterinary Microbiology, Veterinary College and Research Institute, Namakkal- 637002, Tamil Nadu, India

DOI:

https://doi.org/10.48165/ijvsbt.19.5.22

Keywords:

Comet assay, Cypermethrin, Genotoxicity, Piperine, Rats

Abstract

The indiscriminate use of cypermethrin, a type II pyrethorid to enhance crop production has aroused great concern, because this products is likely to reach the aquatic environment, thereby posing a health concern for humans and animals. The aim of the present study was to investigate the protective effect of piperine on cypermethrin-induced genotoxicity in rats. The rats were divided into five groups of six each.  Group I was kept as the control and group II was used as vehicle control. Groups III, IV and V were administered orally with cypermethrin (25 mgkg body wt), piperine (50mg kg body wt) and both daily for 4 weeks, respectively. Administration of cypermethrin (25 mg/kg, p.o.) for 28 days resulted in significant increase in the frequency of micronuclei formation in bone marrow cells and DNA damage. piperine (50 mg/kg, p.o.) administration caused significant reduction in micronuclei formation and marked reduction in DNA damage. The present study revealed that presence of piperine could reduce cypermethrin-induced genotoxicity in rats.

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Published

2023-09-10

Issue

Vol. 19 No. 5 (2023): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Sep-Oct) 2023

Section

Short Communication

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Copyright (c) 2023 Indian Journal of Veterinary Sciences & Biotechnology

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Sankar, P., Telang, A.G., & Ramya, K. (2023). Effect of Piperine on Cypermethrin-Induced Genotoxicity in  Wistar Rats. Indian Journal of Veterinary Sciences and Biotechnology, 19(5), 105–107. https://doi.org/10.48165/ijvsbt.19.5.22
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