Genomic Sequence and Phylogenetic analysis of Canine Parvovirus New 2a Variant Strain in Indian Dogs

Authors

  • Yuvachandran Viva Vimalan Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Raja Paramasivam Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Parthiban Manoharan Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Maha Prabhu Ramalingam Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Parthiban Sivamurthy Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Parthiban Sivamurthy Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Sathish Gopal Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.
  • Sarathchandra Ghadevaru Dean, Faculty of Basic Sciences, Madras Veterinary College Campus, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007.

DOI:

https://doi.org/10.48165/ijvsbt.19.2.09

Keywords:

Canine parvovirus (CPV), CPV-2a Strain, CPV-2b, CPV-2c and Genomic Sequence

Abstract

In this study, a virulent field canine parvovirus type - 2a variant (CPV-new 2a) strain, ABT/CPV/MVC02, was identified from the faeces of a Dog with severe haemorrhagic gastroenteritis in Chennai, Tamil Nadu, India. The genomic sequence of ABT/CPV/MVC02 (MN661243) shares 99.33% nucleotide identity with those of CPV new 2a variant strains. Based on the VP2 capsid protein amino acid variation (Ser297Ala), the ABT/CPV/MVC02 strain is classified as a new CPV 2a variant strain. Two VP2 mutations Tyr324Ile and Thr440Ala were reported in most of the CPV-2a stains also present in ABT/CPV/MVC02.The phylogenetic analysis of the reported strain revealed that it was distinct from existing CPV 2a strains from India and other countries. This complete genomic analysis revealed that the CPV-2a new variant strain circulating in India is evolving rapidly with unique antigenic variations between field CPV-2a and vaccine strains which may be the major cause for vaccine failure in vaccinated dogs.

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Published

2023-03-02

Issue

Vol. 19 No. 2 (2023): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Mar- Apr) 2023

Section

Articles

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Vimalan, Y.V., Paramasivam, R., Manoharan, P., Ramalingam, M.P., Sivamurthy, P., Sivamurthy, P., … Ghadevaru, S. (2023). Genomic Sequence and Phylogenetic analysis of Canine Parvovirus New 2a Variant Strain in Indian Dogs. Indian Journal of Veterinary Sciences and Biotechnology, 19(2), 47–53. https://doi.org/10.48165/ijvsbt.19.2.09
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