Comparative Efficacy of Different Treatment Regimens of Miticidal Drugs in the Clinical Management of Canine Generalized Demodicosis
Keywords:
Amitraz, Canine generalized demodicosis, Doramectin, Imidacloprid Moxidectin, Test product, Treatment regimenAbstract
The present study compared the efficacy of amitraz, doramectin, imidacloprid + moxidectin, test product (Green clean), and its combinations in the clinical management of canine generalized demodicosis. A total of 48 positive cases of generalized demodicosis were selected for the therapeutic trial. The affected dogs were divided into 6 groups, viz., A, B, C, D, E, and F; each group comprised 8 dogs. Six healthy dogs negative for demodectic mites were also used as control (group G) for comparison. The response to treatment was assessed by conducting a clinical examination and parasitological examination of cases at weekly intervals included in the therapeutic trial till clinical recovery (4-7 weeks) or treatment failure. Treatment regimens comprising of a combination of systemic miticidal drugs (doramectin @ 600 µg/kg b.wt. s/c weekly) and a topical miticidal compound (amitraz @ 500 ppm spray weekly or test product 5% spray twice daily) with supportive therapy were more efficacious in resolving the lesions and eliminating the mites than the treatment regimens having single drug (doramectin/amitraz/test product). The combination therapy, along with supportive therapy with benzyl peroxide shampoo, produced appreciable therapeutic results. There was no significant difference between different treatment groups, except Group D (test product), which took a long time for clinical cure.
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