Comparative Efficacy of Different Treatment Regimens of Miticidal Drugs in the Clinical Management of Canine Generalized Demodicosis

Authors

  • Mayank Parwari Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388 001, Gujarat, India
  • Ghanshyam C. Mandali Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388 001, Gujarat, India.
  • Jignasha M. Parmar Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388 001, Gujarat, India.

Keywords:

Amitraz, Canine generalized demodicosis, Doramectin, Imidacloprid Moxidectin, Test product, Treatment regimen

Abstract

The present study compared the efficacy of amitraz, doramectin, imidacloprid + moxidectin, test product (Green clean), and its  combinations in the clinical management of canine generalized demodicosis. A total of 48 positive cases of generalized demodicosis  were selected for the therapeutic trial. The affected dogs were divided into 6 groups, viz., A, B, C, D, E, and F; each group comprised 8  dogs. Six healthy dogs negative for demodectic mites were also used as control (group G) for comparison. The response to treatment was  assessed by conducting a clinical examination and parasitological examination of cases at weekly intervals included in the therapeutic  trial till clinical recovery (4-7 weeks) or treatment failure. Treatment regimens comprising of a combination of systemic miticidal drugs  (doramectin @ 600 µg/kg b.wt. s/c weekly) and a topical miticidal compound (amitraz @ 500 ppm spray weekly or test product 5%  spray twice daily) with supportive therapy were more efficacious in resolving the lesions and eliminating the mites than the treatment  regimens having single drug (doramectin/amitraz/test product). The combination therapy, along with supportive therapy with benzyl  peroxide shampoo, produced appreciable therapeutic results. There was no significant difference between different treatment groups,  except Group D (test product), which took a long time for clinical cure. 

Downloads

Download data is not yet available.

References

Cerundolo, R. (2017). Diagnostic and therapeutic approach to common ectoparasitoses in small animal practice. In Practice, 35(1), 18-23.

Chansiripornchi, P., & Chansiripornchi, N. (2017). Treatment of recurrent demodicosis in dogs using doramectin injection. Indian Veterinary Journal, 94(9), 58-89.

Dimri, U., Singh, S.K., Sharma, M.C., & Kumar, N. (2009). Efficacy of doramectin against canine demodicosis. Indian Veterinary Journal, 86(11), 1127-1128.

Fourie, J.J., Delport, P.C., Fourie, L.J., Heine, J., Horak, I.G., & Krieger, K.J. (2009). Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate®) against generalised demodicosis in dogs. Parasitology Research, 105(1), 115-124.

Fourie, J.J., Liebenberg, J.E., Horak, I.G., Taenzler, J., Heckeroth, A.R., & Frénais, R. (2015). Efficacy of orally administered fluralaner (Bravecto TM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs.

Parasites & Vectors, 8(1), 187.

Hugnet, C., Bruchon-Hugnet, C., Royer, H., & Bourdoiseau, G. (2001). Efficacy of 1.25% amitraz solution in the treatment of generalized demodicosis (eight cases) and sarcoptic mange (five cases) in dogs. Veterinary Dermatology, 12(2), 89-92.

Hutt, J.H., Prior, I.C., & Shipstone, M.A. (2015). Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the USA (2002–2012). Veterinary Dermatology, 26(5), 345-e73.

Kumar, D., Arya, V., Kaur, R., Bhat, Z.A., Gupta, V.K., & Kumar, V. (2012). A review of immunomodulators in the Indian traditional

health care system. Journal of Microbiology, Immunology and Infection, 45(3),165-184.

Medleau, L., & Willemse, T. (1995). Efficacy of daily amitraz on generalised demodicosis in dogs. Journal of Small Animal Practice, 36(1), 3-6.

Mueller, R.S. (2012). An update on the therapy of canine demodicosis. Compendium Continuing Education for Veterinarian, 34(4), E1-4. Nauriyal, D.S. (2015). A project report on "Evaluation of efficacy of nanotechnology based formulation against infections/

infestations of canine skin" submitted to Anand Agricultural University, Anand, Gujarat, India, p. 1-31.

Patel, J.K. (2012). Etio-diagnosis and therapeutic studies on canine demodicosis with special references to lymphocyte blastogenesis and cytokine expression in demodectic dogs. M.V.Sc thesis, Anand Agricultural University, Anand, Gujarat, India.

Paterson, T.E., Halliwell, R.E., Fields, P.J., Louw, M.L., Ball, G., Louw, J., & Pinckney, R. (2014). Canine generalized demodicosis treated with varying doses of a 2.5% moxidectin+ 10% imidacloprid spot-on and oral ivermectin: Parasiticidal effects and long-term treatment outcomes. Veterinary Parasitology, 205(3-4), 687-696.

Paterson, T.E., Halliwell, R.E., Fields, P.J., Louw, M.L., Louw, J.P., Ball, G.S., ... and McKibben, J.S. (2009). Treatment of canine‐

generalized demodicosis: a blind, randomized clinical trial comparing the efficacy of Advocate®(Bayer Animal Health) with ivermectin. Veterinary Dermatology, 20(5‐6): 447-455.

Perego, R., Spada, E., Foppa, C., & Proverbio, D. (2019). Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis. BMC Veterinary Research, 15(1), 17.

Ravera, I., Ferreira, D., Gallego, L.S., Bardagí, M., & Ferrer, L. (2015). Serum detection of IgG antibodies against Demodex canis by western blot in healthy dogs and dogs with juvenile generalized demodicosis. Research in Veterinary Science, 101, 161-164.

Shrestha, D., Thapa, B., Rawal, G., Dhakal, S., & Sharma, B. (2015). Prevalence of demodectic mange in canines of Kathmandu Valley having skin disorder and its associated risk factors. International Journal of Applied Sciences and Biotechnology, 3(3), 459-463.

Singh, H., Haque, M., Singh, N.K., & Rath, S.S. (2011). Prevalence of canine parasitic infections in and around Ludhiana, Punjab. Journal of Veterinary Parasitology, 25(2), 179-180.

Snedecor, G.W., & Cochran, W.G. (1994). Statistical Methods, 7th edn, Oxford and JBH Publishing, New York, USA.

Downloads

Published

2022-01-10

Issue

Vol. 18 No. 1 (2022): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Jan- Mar) 2022

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Parwari, M., Mandali, G.C., & Parmar , .J.M. (2022). Comparative Efficacy of Different Treatment Regimens of Miticidal Drugs in the Clinical Management of Canine Generalized Demodicosis . Indian Journal of Veterinary Sciences and Biotechnology, 18(1), 13–16. Retrieved from https://acspublisher.com/journals/index.php/ijvsbt/article/view/2227