Development of Subunit Vaccine against Poultry Coccidiosis

Authors

  • Vijayashanthi Ramalingam Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India.
  • Raman Muthusamy Translational Re search Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India
  • Kasthuri Bohra Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India.
  • Madan Nithyanantham Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India.
  • Azhahianambi Palavesam Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India.
  • Dhinakarraj Gopal Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai-600051, Tamil Nadu, India.

Keywords:

ELISA, Gametocyte antigen (Gam82), Immunization trial, Intestinal lesion score, Microneme protein 1, Poultry coccidiosis

Abstract

Coccidiosis has a major impact on the economy of the poultry industry worldwide, caused by the protozoan parasite of the genus Eimeria inhabiting the intestinal tract and caecum. The current method of prophylactic use of anti-coccidial drugs led to the emergence of drug resistant isolates with the presence of drug residues in meat and egg. Of the alternate control strategies available, use of recombinant  protein-based vaccines was reported to achieve 30 to 90% reduction in parasite replication with a reduction in intestinal lesion score and  improved feed conversion ratio along with bodyweight gain. In the present study, an immunization trial was conducted on 75 chickens  using the bivalent recombinant candidates comprising of gametocyte antigen (Gam82) from Eimeria maxima and microneme protein  1 (EtMIC1) from Eimeria tenella had been found to offer higher protection against the experimental challenge using field isolates of  mixed Eimeria oocysts (as Group III) for upto 69.23% than those two recombinant protein namely Gam82 (Group I- 34.49%) and EtMIC1  (Group II- 46.15%) given separately, for up to 6 weeks of post-immunization. 

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References

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Published

2022-01-10

Issue

Vol. 18 No. 1 (2022): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Jan- Mar) 2022

Section

Articles

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How to Cite

Ramalingam, V., Muthusamy, R., Bohra, K., Nithyanantham, M., Palavesam, A., & Gopal , D. (2022). Development of Subunit Vaccine against Poultry Coccidiosis . Indian Journal of Veterinary Sciences and Biotechnology, 18(1), 7–12. Retrieved from https://acspublisher.com/journals/index.php/ijvsbt/article/view/2226