Failure of Fenbedazole and Ivermectin to Control Gastrointestinal Nematodes in Goats in Rewa, Madhya Pradesh
DOI:
https://doi.org/10.48165/ijvsbt.20.4.34Keywords:
Anthelmintic resistance, Fenbendazole,, Gastrointestinal nematodes, Goats,, IvermectinAbstract
Anthelmintic resistance has been reported in most goat-raising areas in India, yet little is known about the anthelmintic resistance status in gastrointestinal nematodes in goats in Rewa, Madhya Pradesh. The aim of this study was to determine the occurrence of anthelmintic resistance in goats in field conditions using Faecal Egg Count Reduction test (FECRT). 40 goats having egg per gram above 600 were divided into a control (G1) and three treatment groups (G2, G3 and G4) consisting of 10 goats in each group. Goats which were not given any treatment were kept as control group. Group G2, G3 and G4 goats were treated with fenbendazole @ 7.5 mg/kg BW orally, closantel @ 10 mg/kg BW orally and ivermectin @ 0.2 mg/kg BW subcutaneously, respectively. Percent reduction in faecal egg counts were monitored 14 days after treatment. The FECRT indicated percent reductions of 83, 94 and 94 for G2, G3 and G4, respectively. When analysed statistically using standard WAAVP protocol, anthelmintic resistance against fenbendazole and ivermectin was detected. These findings strongly suggest that anthelmintic resistance is a serious problem in strongyles in goats in Rewa and marked changes in gastrointestinal nematode management need to be instituted immediately to mitigate a worsening situation.
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Chandrawathani, P., Premaalatha, B., Nurulaini, R., Erwanas, A.I., Zaini, C.M., Aizan, M., Ramlan, M. & Khadijah, S. (2013). Severe anthelmintic resistance in two free grazing small holder goat farms in Malaysia. Journal of Veterinary Science and Technology,4(4), 137. doi:10.4172/2157- 7579.1000137
Coles, G.C., Bauer, C., Borgsteede, F.H.M., Geerts, S., Klei, T.R., Taylor, M.A. & Waller, P.J. (1992). World Association for theAdvancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary Parasitology,44, 35–44.
Conder, G.A. & Campbell, W.C. (1995). Chemotherapy of nematode infections of veterinary importance, with special reference to drug resistance. In: Baker JR, Muller R and Rollinson D. (eds.) Advances in Parasitology, Vol 35. Academic Press Ltd, pp. 1-84.
Das, G., Dixit, A.K., Nath, S., Agrawal, V. & Dongre, S. (2015). Levamisole and fenbendazole resistance among gastrointestinal nematodes in goats at Jabalpur, Madhya Pradesh. Journal of Veterinary Parasitology, 29(2), 98-102.
Deepa, C.K. & Devada, K. (2011). In vitro detection of benzimidazole resistance of gastrointestinal nematodes in goats. Journal of Veterinary and Animal Sciences, 42, 73–75.
Dixit, A.K., Das, G., Dixit, P., Singh, A.P., Kumbhakar, N.K., Sankar, M. & Sharma, R.L. (2017).An assessment of benzimidazole resistance against caprine nematodes in Central India. Tropical Animal Health and Production, 49(7), 1471–1478.
Escudero, E., Carceles, C.M., Diaz, M.S., Sutra, J.F., Galtier, P. & Alvinerie M.(1999).Pharmacokinetics of moxidectin and doramectin in goats. Research in Veterinary Science, 67, 177-181.
Jaiswal, A.K., Sudan, V., Shanker, D. & Kumar P. (2013). Emergence of ivermectin resistance in gastrointestinal nematodes of goats in a semi-organized farm of Mathura district – India. Veterinarski Arhiv,83, 275–280.
Maravi, D.S., Dixit, A.K. & Pooja Dixit (2020). Occurrence of gastrointestinal nematodes in goats slaughtered at Rewa, India. Pantnagar Journal of Research,18(3), 261-264.
Martin, P.J. & Wursthorn, L. (1991). RESO faecal egg count reduction test calculator. Melbourne: Council of Scientific and Industrial Research Organization, Division of Animal Health.
Paraud, C., Pors, I., Rehby, L. & Chartier, C. (2010). Absence of ivermectin resistance in a survey on dairy goat nematodes in France. Parasitology Research, 106, 1475–1479.
Premaalatha, B., Chandrawathani, P., Erwanas, A.I., Lily-Rozita, M.H., Jamnah, O., Aizan, Y. & Ramlan, M. (2014). Anthelmintic resistance in small ruminant farms: an ongoing challenge
for perak farmers to control helminths. Malaysian Journal of Veterinary Research, 5(2), 31-38.
Singh, D, Swarnkar, C.P. & Khan, F.A. (2002). Anthelmintic resistance in gastrointestinal nematodes of livestock in India. Journal of Veterinary Parasitology,16, 115–130.
Singh, D. & Swarnkar, C.P. (2008). Role of refugia in management of anthelmintic resistance in nematodes of small ruminants: A review. Indian Journal of Small Ruminants,14, 141-180.
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