Biomarkers for Assessment of Fracture Healing in Dogs with Tibial Fracture

Authors

  • Ghulam Mehdi Department of Veterinary Surgery and Radiology, Veterinary College, Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • Bhagavantappa Department of Veterinary Surgery and Radiology, Veterinary College, Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • B Shivaprakash Department of Veterinary Surgery and Radiology, Veterinary College, Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • Dilip Kumar Department of Veterinary Surgery and Radiology, Veterinary College, Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • D Venkatgiri Department of Veterinary Surgery and Radiology, Veterinary College, Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • Vijay Kumar Department of Veterinary Pharmacology and Toxicology, Veterinary College Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India
  • M Shweta S K Department of Veterinary Gynaecology and Obstetrics, Veterinary College Bidar-585401, Karnataka Veterinary Animal and Fisheries Sciences University, India

DOI:

https://doi.org/10.48165/ijvsbt.20.4.30

Keywords:

Alkaline phosphatase, Calcium, Biomarkers,, , Dog,, Fracture healing,, Phosphorus.

Abstract

The study was conducted in 12 clinical cases of dogs presented to the Department of Veterinary Surgery and Radiology in Bidar. They  were randomly divided into two groups consisting of 6 animals each. In group I fracture was repaired using interlocking nail (ILN) and  in group II with locking compression plate. The fracture healing was studied after the operation on day 0 (immediate), 15th, 30th and  60th. In both groups, calcium, phosphorus and alkaline phosphatase levels were estimated pre-operatively and on the above days for  assessment of fracture healing. The mean values of serum calcium and alkaline phosphatase gradually increased from the pre-operative  day reaching significantly the highest (p<0.05) level on the 15th post-operative day, after which the concentration gradually reduced till  the 60th post-operative day in both the groups. The increase in serum alkaline phosphatase was significantly higher at day 15th post operative in group I than in II, and all the values were within the physiological limit. 

Downloads

Download data is not yet available.

References

Ajjodi, M., & Nagaraja, B.N. (2022). Studies on physiological, hematological and biochemical changes during traumatic compound metatarsal fracture repair by supercutaneous plating technique in bovines. Pharm Innovation Journal, 11(10), 1373-1376.

Delmas, P.D. (1995). Biochemical markers of bone turnover. Acta Orthopaedica Scandinavica, 66, 176-182.

Kumar, K.M., Prasad, V.D., Lakshmi, N.D., & Raju, N.K.B. (2018). Evaluation of biochemical parameters for assessment of fracture healing in dogs. Pharma Innovation Journal, 7(3), 577-580.

Kumar, V., Varshney, A.C., Singh, M., Sharma, S.K., & Nigam, J.M. (1999). Haemato-biochemical changes during fracture repair with hydroxyapatite-fibrillar collagen implants in calves. Indian Journal of Veterinary Surgery, 20(2), 92-93.

Mahendra, A.M., Ranganath, L., & Vasanth, M.S. (2007). Effect of polymethylmethacrylate in femoral fracture repair on haemato-biochemical parameters in dogs. Indian Veterinary Journal, 84(6), 587-589.

Mukhopadhyay, M., Sinha, R., Pal, M., Bhattacharyya, M., Dan, A., & Roy, M.M. (2011). Role of common biochemical markers for the assessment of fracture union. Indian Journakl of Clinical Biochemistry, 26(3), 274-278.

Nagaraja, B.N., Srinivas, C.L., Jayadevappa, S.M., Ranganath, B.N., & Vijayasarathy, S.K. (2003). Biochemical and histopathological changes in dogs with femoral fractures immobilized with plastic rods. Indian Journal of Veterinary Surgery, 24(2), 111-112.

Phaneendra, M.S.S.V., Lakshmi, N.D., Raghunath, M., Raju, N.K.B., & Adilaxmamma, K. (2018). Evaluation of biochemical and haematological parameters for assessment of compound fracture healing in dogs with local antibiotic treatment. International Journal of Livestock Research, 8(4), 138-143.

Snedecor, G.W., & Cochran, W.G. (1994). Statistical Methods. 8th edn. The Iowa State University Press, Ames, Iowa, USA.

Uma Rani, R., & Ganesh, T.N. (2003). Study of serum calcium, phosphorus and alkaline phosphatase during fracture healing of femur in goats. Indian Veterinary Journal, 80(4), 377-378.

Yadav, T., Nagaraja, B.N., Vasanth, M.S., & Mahesh, V. (2021). Studies on physiological, hematological and biochemical changes during tibial fracture repair by intramedullary pinning in bovines. Pharm Innovation Journal, 10(9), 324- 326.

Downloads

Published

2024-07-01

How to Cite

Mehdi, G., Bhagavantappa, Shivaprakash, B., Kumar, D., Venkatgiri, D., Kumar, V., & S K, M.S. (2024). Biomarkers for Assessment of Fracture Healing in Dogs with Tibial Fracture . Indian Journal of Veterinary Sciences and Biotechnology, 20(4), 143–145. https://doi.org/10.48165/ijvsbt.20.4.30