Evaluation of the Cardiovascular Effect of Propofol using Echocardiography in Dogs
DOI:
https://doi.org/10.48165/ijvsbt.20.4.13Keywords:
Cardiovascular changes, Echocardiography,, Dog, Propofol.Abstract
The propofol is commonly used anaesthetic agent in veterinary practice. Propofol has advantage of smooth and rapid induction although causes cardiovascular changes. This study was designed to evaluate cardiovascular changes after induction of anaesthesia with propofol on 12 female Mongrel dogs brought for laparoscopic ovariohysterectomy. The animals were sedated with butorphanol, induced with propofol and maintenance of anaesthesia was done with isoflurane. All dogs underwent a detailed systemic investigation including echocardiographic examination. Heart rate, pulse rate and respiratory rate decreased significantly after induction of anaesthesia, whereas echocardiographic parameters like ejection fraction and cardiac output decreased significantly by 9% and 33%, respectively. The propofol reduced the cardiac output along with decrease in arterial pressure. All these cardiovascular changes were in physiological limits and for transient period, the values of all parameters came to their normal level after recovery.
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Anandmay, A.K., Dass, L.L., Sharma, A.K., Gupta, M.K., Singh, K.K., & Roy, B.K. (2016). Clinico-anaesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs. Veterinary World, 9(11), 1178.
Boon, J.A. (2011) Veterinary Echocardiography. John Wiley & Sons, Chichester, UK.
Cattai, A., Rabozzi, R., Ferasin, H., Isola, M., & Franci, P. (2018). Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring. BMC Veterinary Research, 14, 1-8.
Ebert, T.J., Muzi, M., Berens, R., Goff, D., & Kampine, J.P. (1992). Sympathetic responses to induction of anaesthesia in humans with propofol or etomidate. Anesthesiology, 76(5), 725-733.
Fujinaka, W., Shimizif, J., Iribe, G., Imaoka, T., Oshima, Y., Kiyooka, T., Morita, K., & Mohri S. (2012). Effects of propofol on left ventricular mechanoenergetics in the excised cross-circulated canine heart. Acta Med Okayama, 66, 435-442.
Gugjoo, M.B., Hoque, M., Saxena, A.C., &Zama, M.M.S. (2013). Radiographic, electrocardiographic and echocardiographic features of dilatation cardiomyopathy in dogs. Indian Journal of Veterinary Surgery, 90(12), 54-56.
Ismail, E.F., Kim, S.J., Salem, M.R., & Crystal, G.J. (1992). Direct effects of propofol on myocardial contractility in in situ canine hearts. Anesthesiology, 77(5), 964-972.
Keates, H., & Whittem, T. (2012). Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog. Research in Veterinary Science, 93(2), 904-906.
Kellihan, H.B., Stepien, R.L., Hassen, K.M., &Smith, L.J. (2015). Sedative and echocardiographic effects of dexmedetomidine combined with butorphanol in healthy dogs. Journal of Veterinary Cardiology, 17(4), 282-292.
Lopes, P.C.F., Nunes, N., Sousa, M.G., Paula, D.P., Carareto, R., Nishimori, C., & Camacho, A. A. (2009). Effects of several FiO2 on the echocardiographic parameters in dogs undergoing continuous infusion of propofol. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 61, 345-352.
Mama, Khursheed (2013). Clinician’s Brief, Administration of propofol, an IV anaesthetic, can result in dose-dependent effects, ranging from sedation to general anaesthesia. 17-20. (https://assets.ctfassets.net/4dmg3l1sxd6g/2IFkMJq9E0qDYt
VKOsKeA3/85c73bdbd8d1eaf5c8e29c0e78b72bcd/propofol 8491-article.pdf).
Mulier, J.P., Wouters, P.F., Van Aken, H., Vermaut, G., & Vandermeersch, E. (1991). Cardiodynamic effects of propofol in comparison with thiopental: Assessment with a transesophageal echocardiographic approach. Anesthesia and Analgesia, 72(1), 28-35.
Muzi, M., Berens, R. A., Kampine, J. P., & Ebert, T. J. (1992). Venodilation contributes to propofol-mediated hypotension in humans. Anesthesia & Analgesia, 74(6), 877-883.
Pagel, P.S., & Warltier, D.C. (1993). Negative inotropic effects of propofol as evaluated by the regional preload recruitable stroke work relationship in chronically instrumented dogs. Anesthesiology, 78(1), 100-108.
Pagel, P.S., Hettrick, D.A., Kersten, J.R., Lowe, D., & Warltier, D.C. (1998). Cardiovascular effects of propofol in dogs with dilated cardiomyopathy. The Journal of the American Society of Anesthesiologists, 88(1), 180-189.
Robinson, B.J., Ebert, T.J., O’brien, T.J., Colinco, M.D., & Muzi, M. (1997). Mechanisms whereby propofol mediates peripheral vasolidation in humans: Sympathoinhibition or direct vascular relaxation? The Journal of the American Society of Anesthesiologists, 86(1), 64-72.
Sahinovic, M. M., Struys, M. M. R. F., & Absalom, A. R. (2018). Clinical pharmacokinetics and pharmacodynamics of propofol. Clinical Pharmacokinetics, 57(12), 1539-1558.
Sato, M., Tanaka, M., Umehara, S., & Nishikawa, T. (2005). Baroreflex control of heart rate during and after propofol infusion in humans. British Journal of Anaesthesia, 94(5), 577-581.
Seo, J.I., Han, S.H., Choi, R., Han, J., Lee, L., & Hyun, C. (2015). Cardiopulmonary and anesthetic effects of the combination of butorphanol, midazolam and alfaxalone in Beagle dogs. Veterinary Anaesthesia and Analgesia, 42(3), 304-308.
Shintaku, T., Ohba, T., Niwa, H., Kushikata, T., Hirota, K., Ono, K., ... & Murakami, M. (2014). Effects of propofol on electrocardiogram measures in mice. Journal of Pharmacological Sciences, 126(4), 351-358.
Wouters, P.F., Van de Velde, M.A., Marcus, M.A., Deruyter, H.A., & Van Aken, H. (1995). Haemodynamic changes during induction of anaesthesia with eltanolone and propofol in dogs. Anaesthesia and Analgesia, 81(1), 125-131.
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